YRC Public Data Repository - Protein Structure Prediction

Protein:	ANAPC10
Organism:	Homo sapiens
Length:	185 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for ANAPC10.

Description	E-value	Query Range	Subject Range
APC10_BOVIN - Anaphase-promoting complex subunit 10 OS=Bos taurus GN=ANAPC10 PE=2 SV=1	2.0E-71	[1..185]	[1..185]
gi\|4836700 - gi\|4836700\|gb\|AAD30527.1\| anaphase promoting complex subunit 10 [Homo sapiens]	3.0E-71	[1..185]	[1..185]
gi\|197245971, gi... - gi\|34851573\|ref\|XP_341669.1\| PREDICTED: similar to Anaphase-promoting complex subunit 10 (APC10) (Cy... APC10_MOUSE - Anaphase-promoting complex subunit 10 OS=Mus musculus GN=Anapc10 PE=1 SV=1 tr\|G3H9G3\|G3H9G3... - Anaphase-promoting complex subunit 10 OS=Cricetulus griseus GN=H671_3g9712 PE=3 SV=1	4.0E-71	[1..185]	[1..185]
gi\|56605928, gi\|... - gi\|56605928\|ref\|NP_001008467.1\| anaphase promoting complex subunit 10 [Gallus gallus], gi\|53130520\|e...	9.0E-71	[1..185]	[1..185]
gi\|57870661, gi\|... - gi\|57870661\|gb\|AAH89086.1\| LOC595046 protein [Xenopus laevis], gi\|148234881\|ref\|NP_001089057.1\| hypo...	4.0E-69	[1..185]	[1..185]
gi\|68440237 - gi\|68440237\|ref\|XP_690846.1\| PREDICTED: similar to Anaphase promoting complex subunit 10 (APC10) (Cy...	5.0E-69	[1..185]	[1..187]
gi\|213627011, gi... - gi\|89273769\|emb\|CAJ82095.1\| anaphase promoting complex subunit 10 [Xenopus tropicalis], gi\|62858451\|...	5.0E-69	[1..185]	[1..185]
gi\|47209318 - gi\|47209318\|emb\|CAF92702.1\| unnamed protein product [Tetraodon nigroviridis]	2.0E-67	[1..185]	[1..186]

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Predicted Domain #1

Region A:
Residues: [1-185]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTTPNKTPPG ADPKQLERTG TVREIGSQAV WSLSSCKPGF GVDQLRDDNL ETYWQSDGSQ  60
   61 PHLVNIQFRR KTTVKTLCIY ADYKSDESYT PSKISVRVGN NFHNLQEIRQ LELVEPSGWI 120
  121 HVPLTDNHKK PTRTFMIQIA VLANHQNGRD THMRQIKIYT PVEESSIGKF PRCTTIDFMM 180
  181 YRSIR

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	65.39794
Match:	1jhjA
Description:	APC10/DOC1 subunit of the anaphase-promoting complex
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
ubiquitin-protein ligase activity	6.427112868929	bayes_pls_golite062009
small conjugating protein ligase activity	6.29598849092712	bayes_pls_golite062009
acid-amino acid ligase activity	5.30907713949929	bayes_pls_golite062009
ligase activity, forming carbon-nitrogen bonds	4.14514352069465	bayes_pls_golite062009
binding	2.31774167130542	bayes_pls_golite062009
ligase activity	2.23368019733876	bayes_pls_golite062009
protein binding	0.858220907931067	bayes_pls_golite062009
hydrolase activity	0.690426836233441	bayes_pls_golite062009
nucleic acid binding	0.533285414042183	bayes_pls_golite062009
DNA binding	0.324772578014229	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: