YRC Public Data Repository - Protein Structure Prediction

Protein:	AMPH_ECOLI
Organism:	Escherichia coli
Length:	385 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for AMPH_ECOLI.

Description	E-value	Query Range	Subject Range
gi\|30040053, gi\|... - gi\|30061811\|ref\|NP_835982.1\| beta-lactamase/D-alanine carboxypeptidase [Shigella flexneri 2a str. 24... gi\|24111682, gi\|... - gi\|24111682\|ref\|NP_706192.1\| beta-lactamase/D-alanine carboxypeptidase [Shigella flexneri 2a str. 30... gi\|110804397, gi... - gi\|110804397\|ref\|YP_687917.1\| beta-lactamase/D-alanine carboxypeptidase [Shigella flexneri 5 str. 84...	291.0	[0..1]	[385..1]
gi\|82775726, gi\|... - gi\|82775726\|ref\|YP_402073.1\| beta-lactamase/D-alanine carboxypeptidase [Shigella dysenteriae Sd197],...	291.0	[0..1]	[385..1]
gi\|86573840, gi\|... - gi\|86750812\|ref\|YP_487308.1\| beta-lactamase [Rhodopseudomonas palustris HaA2], gi\|86573840\|gb\|ABD083...	288.0	[0..3]	[377..8]
gi\|192958013, gi... - gi\|75237242\|ref\|ZP_00721289.1\| COG1680: Beta-lactamase class C and other penicillin binding proteins...	288.0	[0..1]	[385..1]
RPA1608 - RPA1608 Beta-lactamase 1787022:1788302 forward MW:47784	287.0	[0..17]	[377..26]
gi\|218557285, gi... - gi\|218557285\|ref\|YP_002390198.1\| beta-lactam binding protein AmpH [Escherichia coli S88], gi\|2183640... gi\|91209437, gi\|... - gi\|91209437\|ref\|YP_539423.1\| beta-lactamase/D-alanine carboxypeptidase [Escherichia coli UTI89], gi\|... gi\|215485459, gi... - gi\|215485459\|ref\|YP_002327890.1\| beta-lactam binding protein AmpH [Escherichia coli O127:H6 str. E23... gi\|26106773, gi\|... - gi\|26246375\|ref\|NP_752414.1\| beta-lactamase/D-alanine carboxypeptidase [Escherichia coli CFT073], gi... gi\|190906201, gi... - gi\|75238704\|ref\|ZP_00722692.1\| COG1680: Beta-lactamase class C and other penicillin binding proteins... gi\|237707638, gi... - gi\|237707638\|ref\|ZP_04538119.1\| penicillin-binding protein ampH [Escherichia sp. 3_2_53FAA], gi\|2268...	287.0	[0..1]	[385..1]
gi\|77654226, gi\|... - gi\|91976240\|ref\|YP_568899.1\| beta-lactamase [Rhodopseudomonas palustris BisB5], gi\|91682696\|gb\|ABE38...	285.0	[0..3]	[377..8]
gi\|109899907, gi... - gi\|76793160\|ref\|ZP_00775651.1\| Beta-lactamase [Pseudoalteromonas atlantica T6c], gi\|76591550\|gb\|EAO6...	285.0	[0..1]	[377..1]
gi\|56414469, gi\|... - gi\|56414469\|ref\|YP_151544.1\| beta-lactam binding protein AmpH [Salmonella enterica subsp. enterica s... gi\|197094867, gi... - gi\|197363390\|ref\|YP_002143027.1\| beta-lactam binding protein AmpH [Salmonella enterica subsp. enteri...	282.0	[0..1]	[385..1]
gi\|62178986, gi\|... - gi\|62178986\|ref\|YP_215403.1\| beta-lactamase/D-alanine carboxypeptidase [Salmonella enterica subsp. e...	281.0	[0..1]	[385..1]

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Predicted Domain #1

Region A:
Residues: [1-385]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MKRSLLFSAV LCAASLTSVH AAQPITEPEF ASDIVDRYAD HIFYGSGATG MALVVIDGNQ  60
   61 RVFRSYGETR PGNNVRPQLD SVVRIASLTK LMTSEMLVKL LDQGTVKLND PLSKYAPPGA 120
  121 RVPTYNGTPI TLVNLATHTS ALPREQPGGA AHRPVFVWPT REQRWKYLST AKLKAAPGSQ 180
  181 AAYSNLAFDL LADALANASG KPYTQLFEEQ ITRPLGMKDT TYTPSPDQCR RLMVAERGAS 240
  241 PCNNTLAAIG SGGVYSTPGD MMRWMQQYLS SDFYQRSNQA DRMQTLIYQR AQFTKVIGMD 300
  301 VPGKADALGL GWVYMAPKEG RPGIIQKTGG GGGFITYMAM IPQKNIGAFV VVTRSPLTRF 360
  361 KNMSDGINDL VTELSGNKPL VIPAS

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	69.69897
Match:	1c3bA
Description:	AMPC beta-Lactamase, class C
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
catalytic activity	1.45893184777336	bayes_pls_golite062009
hydrolase activity	0.744657509700631	bayes_pls_golite062009
beta-lactamase activity	0.2613853997204	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: