YRC Public Data Repository - Protein Structure Prediction

Protein:	ALLR_ECOLI
Organism:	Escherichia coli
Length:	271 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for ALLR_ECOLI.

Description	E-value	Query Range	Subject Range
gi\|77995476, gi\|... - gi\|78043361\|ref\|YP_360107.1\| IclR family transcriptional regulator [Carboxydothermus hydrogenoforman...	294.0	[0..12]	[268..1]
gi\|76589242, gi\|... - gi\|76795434\|ref\|ZP_00777807.1\| regulatory proteins, IclR [Thermoanaerobacter ethanolicus ATCC 33223]... gi\|241902590, gi... - gi\|241902590\|ref\|ZP_04787323.1\| transcriptional regulator, IclR family [Thermoanaerobacter brockii s...	286.0	[0..21]	[269..9]
gi\|149948938, gi... - gi\|77687227\|ref\|ZP_00802500.1\| regulatory proteins, IclR [Alkaliphilus metalliredigenes QYMF], gi\|77...	279.0	[0..18]	[269..2]
gi\|39982384, gi\|... - gi\|39995621\|ref\|NP_951572.1\| IclR family transcriptional regulator [Geobacter sulfurreducens PCA], g...	273.0	[0..12]	[268..2]
gi\|56379913, gi\|... - gi\|56420071\|ref\|YP_147389.1\| IclR family transcriptional regulator [Geobacillus kaustophilus HTA426]...	272.0	[0..12]	[270..1]
gi\|15614700, gi\|... - gi\|15614700\|ref\|NP_243003.1\| IclR family transcriptional regulator [Bacillus halodurans C-125], gi\|1... gi\|25298235 - pir\|\|A83917 transcription regulator (IclR family) BH2137 [imported] - Bacillus halodurans (strain C-...	268.0	[0..21]	[268..2]
gi\|147676812, gi... - gi\|98659900\|dbj\|GAA02725.1\| unnamed protein product [Pelotomaculum thermopropionicum SI], gi\|1476768...	268.0	[0..7]	[266..3]
gi\|78195475, gi\|... - gi\|78224220\|ref\|YP_385967.1\| IclR family transcriptional regulator [Geobacter metallireducens GS-15]...	266.0	[0..12]	[268..2]
gi\|145408989, gi... - gi\|82498737\|ref\|ZP_00884193.1\| regulatory proteins, IclR [Caldicellulosiruptor saccharolyticus DSM 8...	266.0	[0..16]	[260..1]
gi\|83572157, gi\|... - gi\|83589243\|ref\|YP_429252.1\| IclR family transcriptional regulator [Moorella thermoacetica ATCC 3907...	266.0	[0..15]	[267..2]

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Predicted Domain #1

Region A:
Residues: [1-76]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTEVRRRGRP GQAEPVAQKG AQALERGIAI LQYLEKSGGS SSVSDISLNL DLPLSTTFRL  60
   61 LKVLQAADFV YQDSQL

[Run NCBI BLAST on this sequence.]

Detection Method:	FFAS03
Confidence:	3.76
Match:	2ia2A
Description:	No description for 2ia2A was found.

Predicted Domain #2

Region A:
Residues: [77-271]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GWWHIGLGVF NVGAAYIHNR DVLSVAGPFM RRLMLLSGET VNVAIRNGNE AVLIGQLECK  60
   61 SMVRMCAPLG SRLPLHASGA GKALLYPLAE EELMSIILQT GLQQFTPTTL VDMPTLLKDL 120
  121 EQARELGYTV DKEEHVVGLN CIASAIYDDV GSVVAAISIS GPSSRLTEDR FVSQGELVRD 180
  181 TARDISTALG LKAHP

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	41.154902
Match:	1tf1A
Description:	Crystal Structure of the E. coli Glyoxylate Regulatory Protein Ligand Binding Domain
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
transcription regulator activity	2.80545151006505	bayes_pls_golite062009
DNA binding	2.12853183689157	bayes_pls_golite062009
nucleic acid binding	2.06466906422115	bayes_pls_golite062009
transcription factor activity	2.00805912336419	bayes_pls_golite062009
binding	1.3234252548847	bayes_pls_golite062009
transcription repressor activity	0.462491643657442	bayes_pls_golite062009
catalytic activity	0.319188290441009	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: