YRC Public Data Repository - Protein Structure Prediction

Protein:	AK1H_ECOLI
Organism:	Escherichia coli
Length:	820 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for AK1H_ECOLI.

Description	E-value	Query Range	Subject Range
gi\|22127591, gi\|... - gi\|22127591\|ref\|NP_671014.1\| bifunctional aspartokinase I/homeserine dehydrogenase I [Yersinia pesti...	828.0	[0..1]	[820..27]
gi\|26245920, gi\|... - gi\|26245920\|ref\|NP_751959.1\| bifunctional aspartokinase I/homeserine dehydrogenase I [Escherichia co...	827.0	[0..1]	[820..22]
gi\|16120788, gi\|... - gi\|218927656\|ref\|YP_002345531.1\| bifunctional aspartokinase I/homeserine dehydrogenase I [Yersinia p... gi\|162351497, gi... - gi\|77635662\|ref\|ZP_00797744.1\| COG0527: Aspartokinases [Yersinia pestis Angola], gi\|162418682\|ref\|YP... gi\|165920737, gi... - gi\|165927275\|ref\|ZP_02223107.1\| bifunctional aspartokinase/homoserine dehydrogenase I [Yersinia pest... gi\|166009003, gi... - gi\|166009003\|ref\|ZP_02229901.1\| bifunctional aspartokinase/homoserine dehydrogenase I [Yersinia pest... gi\|166211875, gi... - gi\|166211875\|ref\|ZP_02237910.1\| bifunctional aspartokinase/homoserine dehydrogenase I [Yersinia pest... gi\|167401565, gi... - gi\|167401565\|ref\|ZP_02307059.1\| bifunctional aspartokinase/homoserine dehydrogenase I [Yersinia pest... gi\|167418972, gi... - gi\|167418972\|ref\|ZP_02310725.1\| bifunctional aspartokinase/homoserine dehydrogenase I [Yersinia pest... gi\|165915554, gi... - gi\|89104422\|ref\|ZP_01176966.1\| COG0527: Aspartokinases [Yersinia pestis biovar Orientalis str. IP275... gi\|167426040, gi... - gi\|167426040\|ref\|ZP_02317793.1\| bifunctional aspartokinase/homoserine dehydrogenase I [Yersinia pest... gi\|108810041, gi... - gi\|108810041\|ref\|YP_653957.1\| bifunctional aspartokinase I/homeserine dehydrogenase I [Yersinia pest... gi\|167468965 - gi\|167468965\|ref\|ZP_02333669.1\| bifunctional aspartokinase I/homeserine dehydrogenase I [Yersinia pe... gi\|229682023, gi... - gi\|229900684\|ref\|ZP_04515808.1\| bifunctional aspartokinase I/homoserine dehydrogenase I [Yersinia pe... gi\|186893955, gi... - gi\|186893955\|ref\|YP_001871067.1\| bifunctional aspartokinase I/homeserine dehydrogenase I [Yersinia p... gi\|229013121 - gi\|229013121\|ref\|NP_671014.2\| bifunctional aspartokinase I/homeserine dehydrogenase I [Yersinia pest... Q66ET9\|Q66ET9_YERPS - Bifunctional ThrA; aspartokinase I and homoserine dehydrogenase I - Yersinia pseudotuberculosis gi\|229220775 - gi\|229220775\|ref\|NP_994994.2\| bifunctional aspartokinase I/homeserine dehydrogenase I [Yersinia pest... gi\|229705903, gi... - gi\|229836960\|ref\|ZP_04457125.1\| bifunctional aspartokinase I/homoserine dehydrogenase I [Yersinia pe... gi\|229696710, gi... - gi\|229840344\|ref\|ZP_04460503.1\| bifunctional aspartokinase I/homoserine dehydrogenase I [Yersinia pe... gi\|229842424, gi... - gi\|229842424\|ref\|ZP_04462579.1\| bifunctional aspartokinase I/homoserine dehydrogenase I [Yersinia pe... gi\|149289913, gi... - gi\|150260505\|ref\|ZP_01917233.1\| bifunctional aspartokinase/homoserine dehydrogenase I [Yersinia pest... gi\|145600429, gi... - gi\|145600429\|ref\|YP_001164505.1\| bifunctional aspartokinase I/homeserine dehydrogenase I [Yersinia p... gi\|51594953, gi\|... - gi\|51594953\|ref\|YP_069144.1\| bifunctional aspartokinase I/homeserine dehydrogenase I [Yersinia pseud... gi\|25288159 - pir\|\|AH0056 aspartate kinase (EC 2.7.2.4) [imported] - Yersinia pestis (strain CO92)	826.0	[0..1]	[820..1]
gi\|77631588, gi\|... - gi\|77631588\|ref\|ZP_00794174.1\| COG0527: Aspartokinases [Yersinia pseudotuberculosis IP 31758], gi\|15... gi\|169752353, gi... - gi\|170025819\|ref\|YP_001722324.1\| bifunctional aspartokinase I/homeserine dehydrogenase I [Yersinia p...	825.0	[0..1]	[820..1]
gi\|117622296, gi... - gi\|117622296\|ref\|YP_851209.1\| bifunctional aspartokinase I/homeserine dehydrogenase I [Escherichia c...	824.0	[0..1]	[820..15]
gi\|30061573, gi\|... - gi\|30061573\|ref\|NP_835744.1\| bifunctional aspartokinase I/homeserine dehydrogenase I [Shigella flexn... gi\|56383131, gi\|... - gi\|56479580\|ref\|NP_705962.2\| bifunctional aspartokinase I/homeserine dehydrogenase I [Shigella flexn...	822.0	[0..1]	[820..1]
gi\|82775384, gi\|... - gi\|82775384\|ref\|YP_401730.1\| bifunctional aspartokinase I/homeserine dehydrogenase I [Shigella dysen...	822.0	[0..1]	[820..1]
gi\|83585310, gi\|... - gi\|83585310\|ref\|ZP_00923958.1\| COG0527: Aspartokinases [Escherichia coli 101-1], gi\|194439311\|ref\|ZP...	822.0	[0..1]	[820..1]
gi\|73854093, gi\|... - gi\|74310616\|ref\|YP_309035.1\| bifunctional aspartokinase I/homeserine dehydrogenase I [Shigella sonne...	821.0	[0..1]	[820..1]
gi\|19548975 - gi\|19548975\|gb\|AAL90885.1\|AF487900_1 aspartokinase I-homoserine dehydrogenase I [Escherichia coli]	821.0	[0..1]	[820..1]

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Predicted Domain #1

Region A:
Residues: [1-463]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MRVLKFGGTS VANAERFLRV ADILESNARQ GQVATVLSAP AKITNHLVAM IEKTISGQDA  60
   61 LPNISDAERI FAELLTGLAA AQPGFPLAQL KTFVDQEFAQ IKHVLHGISL LGQCPDSINA 120
  121 ALICRGEKMS IAIMAGVLEA RGHNVTVIDP VEKLLAVGHY LESTVDIAES TRRIAASRIP 180
  181 ADHMVLMAGF TAGNEKGELV VLGRNGSDYS AAVLAACLRA DCCEIWTDVD GVYTCDPRQV 240
  241 PDARLLKSMS YQEAMELSYF GAKVLHPRTI TPIAQFQIPC LIKNTGNPQA PGTLIGASRD 300
  301 EDELPVKGIS NLNNMAMFSV SGPGMKGMVG MAARVFAAMS RARISVVLIT QSSSEYSISF 360
  361 CVPQSDCVRA ERAMQEEFYL ELKEGLLEPL AVTERLAIIS VVGDGMRTLR GISAKFFAAL 420
  421 ARANINIVAI AQGSSERSIS VVVNNDDATT GVRVTHQMLF NTD

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	103.0
Match:	2hmfA
Description:	No description for 2hmfA was found.

Predicted Domain #2

Region A:
Residues: [464-820]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 QVIEVFVIGV GGVGGALLEQ LKRQQSWLKN KHIDLRVCGV ANSKALLTNV HGLNLENWQE  60
   61 ELAQAKEPFN LGRLIRLVKE YHLLNPVIVD CTSSQAVADQ YADFLREGFH VVTPNKKANT 120
  121 SSMDYYHQLR YAAEKSRRKF LYDTNVGAGL PVIENLQNLL NAGDELMKFS GILSGSLSYI 180
  181 FGKLDEGMSF SEATTLAREM GYTEPDPRDD LSGMDVARKL LILARETGRE LELADIEIEP 240
  241 VLPAEFNAEG DVAAFMANLS QLDDLFAARV AKARDEGKVL RYVGNIDEDG VCRVKIAEVD 300
  301 GNDPLFKVKN GENALAFYSH YYQPLPLVLR GYGAGNDVTA AGVFADLLRT LSWKLGV

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	73.522879
Match:	1q7gA
Description:	Homoserine Dehydrogenase in complex with suicide inhibitor complex NAD-5-hydroxy-4-Oxonorvaline
Matching Structure (courtesy of the PDB):

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits