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View Structure Prediction Details

Protein: cdc-14
Organism: Caenorhabditis elegans
Length: 707 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for cdc-14.

Description E-value Query
Range
Subject
Range
gi|55665697, gi|... - gi|55665697|emb|CAH70069.1| CDC14 cell division cycle 14 homolog A (S. cerevisiae) [Homo sapiens], g...
542.0 [0..7] [634..1]

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Predicted Domain #1
Region A:
Residues: [1-360]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MREDHSPRRN NTIENTLTEL LPNRLYFGCF PNPDAIDKSD KSVKKTCFIN INNKFHYEPF  60
   61 YEDFGPWNLS VLYRLCVQVG KLLEVEEKRS RRVVLFCQDD GTGQYDKIRV NTAYVLGAYL 120
  121 IIYQGFSADD AYLKVSSGET VKFVGFRDAS MGSPQYLLHL HDVLRGIEKA LKFGWLDFSD 180
  181 FDYEEYEFYE RVENGDFNWI IPGKILSFCG PHNESREENG YPYHAPDVYF DYFRENKVST 240
  241 IVRLNAKNYD ASKFTKAGFD HVDLFFIDGS TPSDEIMLKF IKVVDNTKGG VAVHCKAGLG 300
  301 RTGTLIACWM MKEYGLTAGE CMGWLRVCRP GSVIGPQQPY LIEKQKFCWS LSQSNGVHLT 360
  361 

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 137.0
Match: 1ohcA
Description: Proline directed phosphatase CDC14b2
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
phosphatase activity 0.478406022164162 bayes_pls_golite062009
phosphoric ester hydrolase activity 0.45370611637567 bayes_pls_golite062009
hydrolase activity, acting on ester bonds 0.372398769464001 bayes_pls_golite062009
phosphoprotein phosphatase activity 0.354975426764985 bayes_pls_golite062009
hydrolase activity 0.346372799674989 bayes_pls_golite062009
catalytic activity 0.16233167791503 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [361-479]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 QNKEEKRNVR RLVNQVDDIN LGEERISPKS RENTRPNILR RRVQVQNGRS TAPVTIAPAG  60
   61 TSESRRSTKP SRVVDETALD DQGRSQGDRL LQLKAKHQHE SETTSPNSSS SRRFVKSST

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 44.154902
Match: 1larA
Description: RPTP Lar
Matching Structure (courtesy of the PDB):

Predicted Domain #3
Region A:
Residues: [480-593]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PQMTVPSQAY LNRNREPIIV TPSKNGTSSG TSSRQLKTTP NGNVAYRTRN SSGNTTSTLT  60
   61 RTGNESYRFH NSLFYEPASA VFPSMASRRS ETTRYLSPTT PIKPMSPSYT DGTS

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #4
Region A:
Residues: [594-707]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PRYKARLRSE NPIGSTTSTP FSLQPQITKC SLTAESKPPK RILSMPGTSK STSSLKKIQV  60
   61 SRPRPYPSTG VRVELCANGK SYDIRPRKEA HVIPGAGLAA NTEALLGKRR KTAS

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle