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View Structure Prediction Details

Protein: spk-1
Organism: Caenorhabditis elegans
Length: 774 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for spk-1.

Description E-value Query
Range
Subject
Range
gi|114607104 - gi|114607104|ref|XP_518428.2| PREDICTED: SFRS protein kinase 1 isoform 3 [Pan troglodytes]
296.0 [0..52] [677..175]

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Predicted Domain #1
Region A:
Residues: [1-106]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MGGPEKNSTV PLPNKKRKKK TNKKKPTAPN TPTSPQAGEK NANLKNGTVT TNGSNHVERT  60
   61 EVNANEERLD DLSVSPGRSD SPGGGGGGHS DSFQDPMDPG EQLGSD

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [107-409]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DEEQEDPRDY KRGGYHPVNI GDVFNARYHV IRKLGWGHFS TVWLAWDTQD KRFVAMKIVK  60
   61 SAEHYTEAAL DEIKLLLSVR SADPNDIGCH KVVQLLDEFT VTGINGQHVA MVFEVLGCNL 120
  121 LKLIIRSNYR GLHLEQVRKI CRQVLEALGY MHEKCGIIHT DIKPENVLIT MSREEIKIMA 180
  181 QHAVVARKMN MKMSGSAVST APDHLVKMAQ ENMTKNKKKK MKKKAKKQRE KLEAELAGLE 240
  241 GLKMDANGLQ EAYNNAPQNG VRMRPPSLLF NGPIPQLLQG SSCVNTPSSP RTVPPPPPSL 300
  301 YPQ

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 54.09691
Match: 1wakA
Description: No description for 1wakA was found.

Predicted Domain #3
Region A:
Residues: [410-774]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 VGCVCNQTYH LTQELENFNA SQVEDVTMED TVNENGNRNK VEIRSPDRFD RTTLTPFSDP  60
   61 ESKFGDLASP SAEYLSSPMS QLPPGGILPA PPVGPNIGDP YCDIDVKIAD LGNACWVNHH 120
  121 YTDDIQTRQY RALEVLIGSG YGPPADIWST ACMAFELATG DYLFEPHQGD NYSRDEDHLA 180
  181 HISELLGAIP PSIYKKGKHW REFFHKNGHL LHIHQLKPWS LYEVLRQKYE WSHEDAQQFE 240
  241 SFLRPMLDFD QEKRSTAKIA LKHPFLLPFG GRAPKSDCPP ELLSKMFPDG LIPEPFDGNE 300
  301 HQEVYRDEND SRSASERSAN SRSAGGSDDD DEEEFNMNRP GPSGVITNNE TTDISDIERF 360
  361 QLDLQ

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 61.69897
Match: 1jnkA
Description: THE C-JUN N-TERMINAL KINASE (JNK3S) COMPLEXED WITH MGAMP-PNP
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
protein kinase activity 4.80423821582894 bayes_pls_golite062009
phosphotransferase activity, alcohol group as acceptor 4.62563910354252 bayes_pls_golite062009
kinase activity 4.49248003612191 bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups 4.22000749960953 bayes_pls_golite062009
protein serine/threonine kinase activity 3.79514095722095 bayes_pls_golite062009
transferase activity 3.46855149744418 bayes_pls_golite062009
catalytic activity 1.58699080719302 bayes_pls_golite062009
ATP binding 1.52245797843186 bayes_pls_golite062009
adenyl ribonucleotide binding 1.49413620362406 bayes_pls_golite062009
adenyl nucleotide binding 1.4569583921893 bayes_pls_golite062009
purine ribonucleotide binding 1.24912655063747 bayes_pls_golite062009
ribonucleotide binding 1.24864625022733 bayes_pls_golite062009
purine nucleotide binding 1.21461303193661 bayes_pls_golite062009
nucleotide binding 1.2042473055528 bayes_pls_golite062009
binding 0.816171432010054 bayes_pls_golite062009
receptor signaling protein serine/threonine kinase activity 0.72813241420523 bayes_pls_golite062009
protein tyrosine kinase activity 0.65582668281291 bayes_pls_golite062009
receptor signaling protein activity 0.58533773607974 bayes_pls_golite062009
protein binding 0.530110596588574 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle