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View Structure Prediction Details

Protein: crm-1
Organism: Caenorhabditis elegans
Length: 671 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for crm-1.

Description E-value Query
Range
Subject
Range
FBP1_STRPU - Fibropellin-1 OS=Strongylocentrotus purpuratus GN=EGF1 PE=1 SV=2
286.0 [0..11] [670..191]

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Predicted Domain #1
Region A:
Residues: [1-106]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MQLVVCVFLL LFSFVNFLRT EQSERMHDDC LKAICPLVFH KGCPSDSQLI TVSPAPGNCC  60
   61 PPPGSCHCDQ KKCVPSVPTC TKEERLVMVE KGSDIPGKCC AYYECH

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [107-232]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KKEKKCENVH CPPMFQDEEE CPPDSIRPPE SISKESCCPI RQSCKCRGSI CRPAQCPDGK  60
   61 VVNVTKKGTG FPGRCCDKWE CVDAELSKAK CNHSGIERQP LETWHVSDCE SCQCIRGVSV 120
  121 CNKMTC

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 8.221849
Match: 1tozA
Description: NMR structure of the human NOTCH-1 ligand binding region
Matching Structure (courtesy of the PDB):

Predicted Domain #3
Region A:
Residues: [233-568]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PKVNQECTWI GIPTGECCPV CLGCQTDNQT KLERGATWQK DDCTSCTCSE LGAHMCEKYM  60
   61 CKTDCENPRK VEGQCCPVCD EPTIIRPPAT CPSLELCSLR CANGLRRDNI GCYVCECLPD 120
  121 EVPTNPRCRE LNDENCEKQC AHGYLKDEDG CTVCKCSKCP PLHQCHKHCL YGFETNSAGC 180
  181 SLCKCRASSK LDKKQGTTKS TKLGAGSAQQ TEYHSEKCIS FSNDGHQIVR DGGEWWSDGC 240
  241 RHCFCENKQE FCSLISCPTK PSDCADEKWV QKEDECCPSC IDQKKKPKSS NSLAAQKHEH 300
  301 TVCQSPGTGR LFTDGETWQL APCVSCTCRV GHVLCR

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 7.69897
Match: 1n7dA
Description: Low density lipoprotein (LDL) receptor YWTD domain; Low density lipoprotein (LDL) receptor, different EGF domains; Ligand-binding domain of low-density lipoprotein receptor
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
binding 0.286076792172079 bayes_pls_golite062009
protein binding 0.14494900666454 bayes_pls_golite062009

Predicted Domain #4
Region A:
Residues: [569-671]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 TTECPPIACP NPEYQNEEDC CPTCPEQKVE NTKNEKGDTI VCTDDAGTAH IVAAQVQRSR  60
   61 PNSIGGSINS KTFSVKNNWI HAKTRGLEGH ERRKYGGIVE DIN

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.


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