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View Structure Prediction Details

Protein: TOP1_ARATH
Organism: Arabidopsis thaliana
Length: 916 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for TOP1_ARATH.

Description E-value Query
Range
Subject
Range
gi|9954905 - gi|9954905|pdb|1EJ9|A Chain A, Crystal Structure Of Human Topoisomerase I Dna Complex
663.0 [0..357] [913..1]
gi|57639320 - gi|57639320|gb|AAW55580.1| TOP1 [Macaca fascicularis]
661.0 [0..360] [913..1]

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Predicted Domain #1
Region A:
Residues: [1-174]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MGTETVSKPV MDNGSGDSDD DKPLAFKRNN TVASNSNQSK SNSQRSKAVP TTKVSPMRSP  60
   61 VTSPNGTTPS NKTSIVKSSM PSSSSKASPA KSPLRNDMPS TVKDRSQLQK DQSECKIEHE 120
  121 DSEDDRPLSS ILSGNKGPTS SRQVSSPQPE KKNNGDRPLD RASRIIKDES DDET

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [175-334]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PISSMFRKKI DSGMSGGNQL SNDEKKPLVQ KLHQNGSTVK NEVPNGKVLG KRPLEKNSSA  60
   61 DQSSLKKAKI SASPTSVKMK QDSVKKEIDD KGRVLVSPKM KAKQLSTRED GTDDDDDDDV 120
  121 PISKRFKSDS SNSNTSSAKP KAVKLNSTSS AAKPKARNVV 

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [335-916]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SPRSRAMTKN TKKVTKDSKY STSSKSSPSS GDGQKKWTTL VHNGVIFPPP YKPHGIKILY  60
   61 KGKPVDLTIE QEEVATMFAV MRETDYYTKP QFRENFWNDW RRLLGKKHVI QKLDDCDFTP 120
  121 IYEWHLEEKE KKKQMSTEEK KALKEEKMKQ EEKYMWAVVD GVKEKIGNFR VEPPGLFRGR 180
  181 GEHPKMGKLK KRIHPCEITL NIGKGAPIPE CPIAGERWKE VKHDNTVTWL AFWADPINPK 240
  241 EFKYVFLGAG SSLKGLSDKE KYEKARNLTD HIDNIRTTYT KNFTAKDVKM RQIAVATYLI 300
  301 DKLALRAGNE KDDDEADTVG CCTLKVGNVE CIPPNKIKFD FLGKDSIQYV NTVEVEPLVY 360
  361 KAIGQFQAGK SKTDDLFDEL DTSKLNAHLK ELVPGLTAKV FRTYNASITL DEMLSQETKD 420
  421 GDVTQKIVVY QKANKEVAII CNHQRTVSKT HGAQIEKLTA RIEELKEVLK ELKTNLDRAK 480
  481 KGKPPLEGSD GKKIRSLEPN AWEKKIAQQS AKIEKMERDM HTKEDLKTVA LGTSKINYLD 540
  541 PRITVAWCKR HEVPIEKIFT KSLLEKFAWA MDVEPEYRFS RR

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 1000.0
Match: 1nh3A
Description: Eukaryotic DNA topoisomerase I, catalytic core; Eukaryotic DNA topoisomerase I, N-terminal DNA-binding fragment
Matching Structure (courtesy of the PDB):

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle