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View Structure Prediction Details

Protein: MTHR2_ARATH
Organism: Arabidopsis thaliana
Length: 594 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for MTHR2_ARATH.

Description E-value Query
Range
Subject
Range
MTHR1_ARATH - Methylenetetrahydrofolate reductase 1 OS=Arabidopsis thaliana GN=MTHFR1 PE=1 SV=1
916.0 [0..1] [592..1]

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Predicted Domain #1
Region A:
Residues: [1-300]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MKVIDKIQSL ADEGKTAFSF EFFPPKTEDG VDNLFERMDR MVAYGPTFCD ITWGAGGSTA  60
   61 DLTLDIASRM QNVVCVESMM HLTCTNMPVE KIDHALETIR SNGIQNVLAL RGDPPHGQDK 120
  121 FVQVEGGFDC ALDLVNHIRS KYGDYFGITV AGYPEAHPDV IGENGLASNE AYQSDLEYLK 180
  181 KKIDAGADLI VTQLFYDTDI FLKFVNDCRQ IGISCPIVPG IMPINNYRGF LRMTGFCKTK 240
  241 IPVEVMAALE PIKDNEEAVK AYGIHLGTEM CKKMLAHGVK SLHLYTLNME KSALAILMNL 300
  301 

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 103.0
Match: 1v93A
Description: 5,10-Methylenetetrahydrofolate Reductase from Thermus thermophilus HB8
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
methylenetetrahydrofolate reductase (NADPH) activity 3.97406471031265 bayes_pls_golite062009
oxidoreductase activity, acting on the CH-NH group of donors 3.43788898294589 bayes_pls_golite062009
oxidoreductase activity 3.26500423104107 bayes_pls_golite062009
oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor 2.35093189018748 bayes_pls_golite062009
catalytic activity 2.15527229494088 bayes_pls_golite062009
1-pyrroline-5-carboxylate dehydrogenase activity 2.11575302268542 bayes_pls_golite062009
binding 1.55766253746824 bayes_pls_golite062009
transcription regulator activity 0.413628997019645 bayes_pls_golite062009
nucleic acid binding 0.385543917258092 bayes_pls_golite062009
protein binding 0.229798056306674 bayes_pls_golite062009
DNA binding 0.214617895050106 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [301-372]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GMIDESKISR SLPWRRPANV FRTKEDVRPI FWANRPKSYI SRTKGWEDFP QGRWGDSRSA  60
   61 SYGALSDHQF SR

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [373-594]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PRARDKKLQQ EWVVPLKSVE DIQEKFKELC LGNLKSSPWS ELDGLQPETR IINEQLIKVN  60
   61 SKGFLTINSQ PSVNAERSDS PTVGWGGPVG YVYQKAYLEF FCSKEKLDAV VEKCKALPSI 120
  121 TYMAVNKGEQ WVSNTAQADV NAVTWGVFPA KEIIQPTIVD PASFNVWKDE AFETWSRSWA 180
  181 NLYPEADPSR NLLEEVKNSY YLVSLVENDY INGDIFAVFA DL

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle