YRC Public Data Repository - Protein Structure Prediction

Protein:	lkh1
Organism:	Schizosaccharomyces pombe
Length:	690 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for lkh1.

Description	E-value	Query Range	Subject Range
CDC2_OXYRB - Cell division control protein 2 homolog OS=Oxybasis rubra GN=CDC2 PE=2 SV=1	308.0	[0..359]	[685..1]
gi\|254839180, gi... - gi\|93278865\|pdb\|2BKZ\|C Chain C, Structure Of Cdk2-Cyclin A With Pha-404611, gi\|93278863\|pdb\|2BKZ\|A C...	306.0	[0..357]	[688..4]
gi\|117499872 - gi\|117499872\|gb\|ABK34941.1\| cyclin-dependent kinase 2 [Capra hircus] gi\|215983068, gi... - gi\|215983068\|ref\|NP_001135981.1\| cyclin-dependent kinase 2 [Ovis aries], gi\|213688920\|gb\|ACJ53943.1\|... CDK2_BOVIN - Cyclin-dependent kinase 2 OS=Bos taurus GN=CDK2 PE=2 SV=1	306.0	[0..359]	[688..1]
CDC2A_ANTMA - Cell division control protein 2 homolog A OS=Antirrhinum majus GN=CDC2A PE=2 SV=2	306.0	[0..359]	[685..1]
gi\|109097199 - gi\|109097199\|ref\|XP_001113345.1\| PREDICTED: cyclin-dependent kinase 2 isoform 6 [Macaca mulatta]	306.0	[0..359]	[688..1]
gi\|30583821, gi\|... - gi\|61372546\|gb\|AAX43864.1\| cyclin-dependent kinase 2 [synthetic construct], gi\|60830574\|gb\|AAX36935....	306.0	[0..359]	[688..1]
CDK2_CRIGR - Cyclin-dependent kinase 2 OS=Cricetulus griseus GN=CDK2 PE=2 SV=1	305.0	[0..359]	[688..1]
gi\|83408542 - gi\|83408542\|emb\|CAD43177.2\| putative cyclin dependent kinase [Coffea arabica]	305.0	[0..359]	[685..1]

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Predicted Domain #1

Region A:
Residues: [1-185]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MHSLKRRRNH APDWQDFYKN GVPQEVIVIE DSASPRLTPN LPPPFSVHQL QSFVPPQPPS  60
   61 SSSPSTTGTV AVPINGANAV YPSTNSVSLP QSYDPWLDAN GVVPLPHDVA SHPSYMVQSP 120
  121 TSYHACSNNQ SPFPHSHHPP LHNPLPVSCQ PVLRPPPVPQ VPSHWYPVSL PSPNLPHQPI 180
  181 SKPPV

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2

Region A:
Residues: [186-358]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 IPNLPKLQVH PNRLPHPIHN HPYSSPTSYP PPLCPATYCP SNPPQLAPAT AIAPSSQSSQ  60
   61 HKSVNYSVTP SSINNHTAVP LSPTLAVWLP MTQPTFQPPS ANVYQPASNA NQVITPVSIS 120
  121 DYRPPKKRKR AAWPPYKKVD RVNVPVVHDT TAFDPSTFDD DDGHYKVVPN SKF

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #3

Region A:
Residues: [359-690]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ANRYTVVRLL GHGTFGKVIQ CYDQSTGRHC AIKVTRAIPK YREASLIELR VLQTIAHSDP  60
   61 TNENKCIQLR DYFDYRKHIC IVTDLFGWSV FDFLKNNNYI PFPLKHIQML SQQLFKSVAF 120
  121 LHSLGLVHTD LKPENVLLVS NASRTIRLPY RNYSQKVLNS CEIRLIDFGS ATFEDEYHSS 180
  181 VVSTRHYRAP EIILGLGWSY PCDVWSIGCI LVELFTGQAL FQTHEDSEHL CMMEKILGPF 240
  241 DRNMISRSSR TSQRFFKSDG KVRYPLSNTP KKSINYLQSL QTLEQIFAVS SPEVALLLDL 300
  301 LKKVFVYDPK RRITAKEALW HPFFTQPISS NL

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	74.69897
Match:	1z57A
Description:	Crystal structure of human CLK1 in complex with 10Z-Hymenialdisine
Matching Structure (courtesy of the PDB):

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits