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View Structure Prediction Details

Protein: wah-1
Organism: Caenorhabditis elegans
Length: 700 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for wah-1.

Description E-value Query
Range
Subject
Range
gi|148260619, gi... - gi|88940152|ref|ZP_01145593.1| Dihydrolipoamide dehydrogenase [Acidiphilium cryptum JF-5], gi|889210...
357.0 [0..238] [700..1]

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Predicted Domain #1
Region A:
Residues: [1-154]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MLLRAVGRQM TSVIFRQQTA VRSIAMSRVA LGGGGHHHEP TPVYIPKPGS LDWTFFSRSH  60
   61 TKSAHEFEPY KPEIGAFIGA VAFIGLTLIA VVIKTDVFKK EDSHGHGHGH AKHSKKHEEK 120
  121 HEQKHEEKEH AEPEKKEEAK PEKPAEPKEP EPAQ

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [155-221]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KQAEQPEQAE EKQETKDAEP KEQVDDRQTE EAVHARRAPA AAEEPAPSTS KADAVEEKRS  60
   61 EQQSMKP

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 9.30103
Match: 1djnA
Description: Trimethylamine dehydrogenase, N-terminal domain; Trimethylamine dehydrogenase, C-terminal domain; Trimethylamine dehydrogenase, middle domain
Matching Structure (courtesy of the PDB):

Predicted Domain #3
Region A:
Residues: [222-700]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SESTEENTTT TSADGLLHCE YVIIGSGTAA YYASLSIRAK QAEAKVLMIG EEPELPYNRP  60
   61 PLSKELWWYG DETSATKLAY TPLSGKKRDI FYEVDGFFVS PEDLPKAVHG GVALLRGRKA 120
  121 VKICEEDKKV ILEDGTTIGY DKLLIATGVR PKKEQVFEEA SEEAKQKITY FHYPADFKRV 180
  181 ERGLADKSVQ KVTIIGNGLL ASELSYSIKR KYGENVEVHQ VFEEKYPAED ILPEHIAQKS 240
  241 IEAIRKGGVD VRAEQKVEGV RKCCKNVVLK LSDGSELRTD LVVVATGEEP NSEIIEASGL 300
  301 KIDEKLGGVR ADKCLKVGEN VWAAGAIATF EDGVLGARRV SSWENAQISG RLAGENMATA 360
  361 AADGKSEGKA FWYQPSFFTK FAPHLHINAI GKCDSSLETV SVHAEPDKDT PLEKAVVFYK 420
  421 SKEDGSIVGV LLLNVFGPSL DVARRIIDDR KKVDEYKEIA KLFPLYDPVK SDEDDAKSA

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 55.045757
Match: 1gv4A
Description: Apoptosis-inducing factor (AIF)
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
catalytic activity 1.93817882455555 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle