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View Structure Prediction Details

Protein: hif-1
Organism: Caenorhabditis elegans
Length: 503 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for hif-1.

Description E-value Query
Range
Subject
Range
CE18671 - WBGene00001851 locus:hif-1 status:Partially_confirmed TR:O45486 protein_id:CAA19520.1
228.0 [0..13] [503..333]

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Predicted Domain #1
Region A:
Residues: [1-137]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSRDSEYLDR KYTESPMGAF TTRHTCDMRI TFVSDKFNYI LKSELKTLMG TSFYELVHPA  60
   61 DMMIVSKSMK ELFAKGHIRT PYYRLIAAND TLAWIQTEAT TITHTTKGQK GQYVICVHYV 120
  121 LGIQGAEESL VVCTDSM

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 36.0
Match: 1p97A
Description: NMR structure of the C-terminal PAS domain of HIF2a
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
binding 0.438711522487185 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [138-371]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PAGMQVDIKK EVDDTRDYIG RQPEIVECVD FTPLIEPEDP FDTVIEPVVG GEEPVKQADM  60
   61 GARKNSYDDV LQWLFRDQPS SPPPARYRSA DRFRTTEPSN FGSALASPDF MDSSSRTSRP 120
  121 KTSYGRRAQS QGSRTTGSSS TSASATLPHS ANYSPLAEGI SQCGLNSPPS IKSGQVVYGD 180
  181 ARSMGRSCDP SDSSRRFSAL SPSDTLNVSS TRGINPVIGS NDVFSTMPFA DSIA

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [372-503]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 IAERIDSSPT LTSGEPILCD DLQWEEPDLS CLAPFVDTYD MMQMDEGLPP ELQALYDLPD  60
   61 FTPAVPQAPA ARPVHIDRSP PAKRMHQSGP SDLDFMYTQH YQPFQQDETY WQGQQQQNEQ 120
  121 QPSSYSPFPM LS

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.


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