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View Structure Prediction Details

Protein: let-413
Organism: Caenorhabditis elegans
Length: 679 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for let-413.

Description E-value Query
Range
Subject
Range
gi|186464136, gi... - gi|23128321|ref|ZP_00110172.1| COG4886: Leucine-rich repeat (LRR) protein [Nostoc punctiforme PCC 73...
416.0 [0..4] [481..30]

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Predicted Domain #1
Region A:
Residues: [1-387]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MPAFFCLPMA CQRQVDSIDR SQSNLQAIPS DIFRFRKLED LNLTMNNIKE LDHRLFSLRH  60
   61 LRILDVSDNE LAVLPAEIGN LTQLIELNLN RNSIAKLPDT MQNCKLLTTL NLSSNPFTRL 120
  121 PETICECSSI TILSLNETSL TLLPSNIGSL TNLRVLEARD NLLRTIPLSI VELRKLEELD 180
  181 LGQNELEALP AEIGKLTSLR EFYVDINSLT SLPDSISGCR MLDQLDVSEN QIIRLPENLG 240
  241 RMPNLTDLNI SINEIIELPS SFGELKRLQM LKADRNSLHN LTSEIGKCQS LTELYLGQNF 300
  301 LTDLPDTIGD LRQLTTLNVD CNNLSDIPDT IGNCKSLTVL SLRQNILTEL PMTIGKCENL 360
  361 TVLDVASNKL PHLPFTVKVL YKLQALW

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 46.0
Match: 2omuA
Description: No description for 2omuA was found.

Predicted functions:

Term Confidence Notes
signal transducer activity 2.54176035045352 bayes_pls_golite062009
molecular transducer activity 2.54176035045352 bayes_pls_golite062009
receptor activity 2.44108148686445 bayes_pls_golite062009
transmembrane receptor activity 2.25077658159974 bayes_pls_golite062009
protein kinase activity 1.61450095469422 bayes_pls_golite062009
G-protein coupled receptor activity 1.37462680876315 bayes_pls_golite062009
phosphotransferase activity, alcohol group as acceptor 1.36168522830563 bayes_pls_golite062009
kinase activity 1.28067810202729 bayes_pls_golite062009
binding 1.23313855731605 bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups 0.875083054478353 bayes_pls_golite062009
protein binding 0.646159692466759 bayes_pls_golite062009
transferase activity 0.435331931559158 bayes_pls_golite062009
protein tyrosine kinase activity 0.231213253402712 bayes_pls_golite062009
nucleic acid binding 0.205944109094333 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [388-507]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LSENQTQSIL KLSETRDDRK GIKVVTCYLL PQVDAIDGEG RSGSAQHNTD RGAFLGGPKV  60
   61 HFHDQADTTF EENKEAEIHL GNFERHNTPH PKTPKHKKGS IDGHMLPHEI DQPRQLSLVS 120
  121 

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 36.69897
Match: 2id5A
Description: No description for 2id5A was found.

Predicted Domain #3
Region A:
Residues: [508-565]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NHRTSTSSFG ESSNSINRDL ADIRFIDAPA SAQNGVREAT LSPEREERMA TSLSSLSN

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #4
Region A:
Residues: [566-679]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LAAGTQNMHT IRIQKDDTGK LGLSFAGGTS NDPAPNSNGD SGLFVTKVTP GSAAYRCGLR  60
   61 EGDKLIRAND VNMINASQDN AMEAIKKRET VELVVLRRSP SPVSRTSVSR PCEY

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 14.69897
Match: 1iu0A
Description: Synaptic protein PSD-95
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
binding 2.6196222853442 bayes_pls_golite062009
protein binding 2.35875654816667 bayes_pls_golite062009
kinase activity 1.29833697558449 bayes_pls_golite062009
transporter activity 1.18978519116375 bayes_pls_golite062009
cytoskeletal protein binding 1.11584635608743 bayes_pls_golite062009
transmembrane transporter activity 1.07211582292329 bayes_pls_golite062009
signal transducer activity 1.06018756723145 bayes_pls_golite062009
molecular transducer activity 1.06018756723145 bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups 0.851396699088923 bayes_pls_golite062009
substrate-specific transporter activity 0.755223974149211 bayes_pls_golite062009
PDZ domain binding 0.71844819286977 bayes_pls_golite062009
protein domain specific binding 0.64214865642772 bayes_pls_golite062009
protein kinase binding 0.54934142458843 bayes_pls_golite062009
substrate-specific transmembrane transporter activity 0.549085929250683 bayes_pls_golite062009
kinase binding 0.541050170070789 bayes_pls_golite062009
receptor binding 0.359972518335054 bayes_pls_golite062009
transferase activity 0.325404241870749 bayes_pls_golite062009
beta-catenin binding 0.27594880120163 bayes_pls_golite062009
enzyme binding 0.265928259068924 bayes_pls_golite062009
actin binding 0.263747574646927 bayes_pls_golite062009
active transmembrane transporter activity 0.252733105474942 bayes_pls_golite062009
phosphatase binding 0.24515474358339 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle