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View Structure Prediction Details

Protein: hlh-1
Organism: Caenorhabditis elegans
Length: 319 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for hlh-1.

Description E-value Query
Range
Subject
Range
hlh-1 - helix-loop-helix transcription factor status:Partially_confirmed UniProt:P22980 protein_id:AAN39684....
192.0 [0..1] [301..1]

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Predicted Domain #1
Region A:
Residues: [1-140]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MNTETSTQSA PSDTYDTSIY YNSSPRVTAN DITTLTSFAA PAPQVLDYAN TQYDIYRNQP  60
   61 AYYLPSYAPT APTTFYSDFA NFNVTRSQDF ASVPAVANSS DVKPIIIKQE KSTPNATELI 120
  121 IQSRVDSQHE DTTTSTAGGA 

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [141-224]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GVGGPRRTKF VLSVDRRKAA TMRERRRLRK VNEAFEVVKQ RTCPNPNQRL PKVEILRSAI  60
   61 DYINNLERML QQAGKMTKIM EQNQ

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 17.09691
Match: 1mdyA
Description: Myod B/HLH domain
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
binding 2.28018660287528 bayes_pls_golite062009
transcription regulator activity 1.87754990073909 bayes_pls_golite062009
DNA binding 1.73664400879211 bayes_pls_golite062009
transcription factor activity 1.6095946900662 bayes_pls_golite062009
nucleic acid binding 1.57122223638621 bayes_pls_golite062009
protein binding 0.78099405089238 bayes_pls_golite062009
transcription activator activity 0.314165294474 bayes_pls_golite062009

Predicted Domain #3
Region A:
Residues: [225-319]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 HLQMTQQING APPHDYVTSS HFASSSYNPE NMFDDDDLTD SDDDRDHHKL GNGELLLKTN  60
   61 GRSASAKLFG QIVADRCEHS QRGSNDRRTT PPTSK

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.


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Created and Maintained by: Michael Riffle