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View Structure Prediction Details

Protein: alh-6
Organism: Caenorhabditis elegans
Length: 563 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for alh-6.

Description E-value Query
Range		 Subject
Range
AL1B1_PONAB - Aldehyde dehydrogenase X, mitochondrial OS=Pongo abelii GN=ALDH1B1 PE=2 SV=1
AL1B1_PONPY - Aldehyde dehydrogenase X, mitochondrial precursor - Pongo pygmaeus (Orangutan)
 575.0 [0..36] [550..7]

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Predicted Domain #1
Region A:
Residues: [1-563] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MLSFAARRSL ITQKCAASTY SGLTSADFLK KKTNEPILEY RKGSKERQDL EAALAFYSKN  60
   61 ITEVPLRIGD KKITNKLEQK QVIPSDHRST LAKYTYATGE QIQEAIDVAL QARGAWERKP 120
  121 LKERAEILLR AADLAAGKYR MKLNASTMLG QGKNIIQAEI DAACELIDFF RFNAVFAMEL 180
  181 EHYEPISTKI TKNTMQFRGM EGFVAAIAPF NFTAIGGNLP TAPALMGNVS LWKPSNTAVL 240
  241 SNYIIYELLE EAGMPPGILS FLPSDGPVFG DVITASPHLS AVNFTGSVPT FKTIWRKVAE 300
  301 NLDNYVTFPK LIGECGGKNF HFVHPSAHVD AVAAGTARSA WEYSGQKCSA CSRMYAPKSI 360
  361 WPKILEKISA IHKEIKLGDV RDGSVFLSAV IDDKAFARLK AYIDFAKTGA DGANVVLGGK 420
  421 CDDKTGYFIE PTLITVTDPK SKLLTEEMFG PVVTVLVYED SKVDEVLATV KDATPYGLTG 480
  481 AVFSQDKEFL YRARDVLRDA VGNMYLNDKS TGSIVGQQPF GGSRLSGTND KAGGPHYGLR 540
  541 WTSPLTIKET SVSLTDWKYP SME

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 163.0
Match: 1bxsA
Description: Aldehyde reductase (dehydrogenase), ALDH
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
oxidoreductase activity, acting on the aldehyde or oxo group of donors 5.09598561374689 bayes_pls_golite062009
oxidoreductase activity 4.47226217021998 bayes_pls_golite062009
1-pyrroline-5-carboxylate dehydrogenase activity 4.35175408702761 bayes_pls_golite062009
methylmalonate-semialdehyde dehydrogenase (acylating) activity 3.87605237828483 bayes_pls_golite062009
succinate-semialdehyde dehydrogenase [NAD(P)+] activity 3.64672165191647 bayes_pls_golite062009
3-chloroallyl aldehyde dehydrogenase activity 3.37049090049734 bayes_pls_golite062009
oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor 3.2867555127991 bayes_pls_golite062009
glutamate-5-semialdehyde dehydrogenase activity 3.27180265380824 bayes_pls_golite062009
benzaldehyde dehydrogenase activity 2.99564252244797 bayes_pls_golite062009
aldehyde dehydrogenase (NAD) activity 2.81851373615334 bayes_pls_golite062009
catalytic activity 2.80804701752928 bayes_pls_golite062009
succinate-semialdehyde dehydrogenase activity 2.71501590413507 bayes_pls_golite062009
oxidoreductase activity, acting on the CH-NH group of donors 2.70230501280821 bayes_pls_golite062009
aldehyde dehydrogenase [NAD(P)+] activity 2.43250909158896 bayes_pls_golite062009
aminobutyraldehyde dehydrogenase activity 2.35958138496479 bayes_pls_golite062009
malonate-semialdehyde dehydrogenase (acetylating) activity 1.75951883819887 bayes_pls_golite062009
oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor 1.6559690223037 bayes_pls_golite062009
retinal dehydrogenase activity 1.42867174920845 bayes_pls_golite062009
binding 1.06673666884196 bayes_pls_golite062009
protein binding 0.894945263794726 bayes_pls_golite062009
retinoid binding 0.801468424891608 bayes_pls_golite062009
isoprenoid binding 0.719034630339067 bayes_pls_golite062009
histidinol dehydrogenase activity 0.258030369394064 bayes_pls_golite062009
benzaldehyde dehydrogenase (NAD+) activity 0.23487570676521 bayes_pls_golite062009
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