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View Structure Prediction Details

Protein: lin-17
Organism: Caenorhabditis elegans
Length: 556 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for lin-17.

Description E-value Query
Range
Subject
Range
gi|76661271 - gi|76661271|ref|XP_602576.2| PREDICTED: similar to frizzled 7 [Bos taurus]
369.0 [0..1] [514..456]

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Predicted Domain #1
Region A:
Residues: [1-170]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MMHSLGIILL FIPLATGSIF DQAVKGKCIP IDIELCKDLP YNYTYFPNTI LHNDQHTLQT  60
   61 HTEHFKPLMK TKCHPHIHFF ICSVFAPMCP IGMPQAVTSC KSVCEQVKAD CFSILEEFGI 120
  121 GWPEPLNCAQ FPDPPELCMK PTEDEITGGF SAPRLPTKGS SSSSSKPTGC 

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 35.30103
Match: 1ijyA
Description: Frizzled 8 (FZ8)
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
Wnt receptor activity 5.34849208575619 bayes_pls_golite062009
Wnt-protein binding 4.48351937520811 bayes_pls_golite062009
transmembrane receptor activity 4.38708793497137 bayes_pls_golite062009
receptor activity 4.1046853496316 bayes_pls_golite062009
signal transducer activity 3.17034085692897 bayes_pls_golite062009
molecular transducer activity 3.17034085692897 bayes_pls_golite062009
binding 1.75284371400205 bayes_pls_golite062009
protein binding 1.1012033332744 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [171-556]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PSDLVDVDPH DPKSHCAFAC QSNVMFSTDN KRMVRSWSIW FAAANAGVAL FSFLTFAIDR  60
   61 KRFRFPERCV FYLSLCIFIS SLPYLTPLFI DAPIRSCHAL GNGRSYLSIG TFDNSYCLAS 120
  121 FLLNYFFSTA AALWWLMFSF TLYLSGGRKW VPEGIEACSS YVHFVAWGLS SLATIIVLIF 180
  181 NKVDASELTA LCSVGNLNSI ALLWFVIVPR TICIVIGTCF IVGGFASMCR ERISFRTRGT 240
  241 DTSKLEKLMV KMGFFCALFI LPNVIELVCQ CYKFMILTQW TRMTIDCKQQ SGACHRPTPP 300
  301 QAEIYMTAVI SSLATGFSCL MWVLSAKTVH AWKNFIFCGM CSSAPVKVKP NRAINTSIAR 360
  361 ATNCSATTTT GIHANGDESS EFMETQ

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 18.69897
Match: 1f88A
Description: Rhodopsin
Matching Structure (courtesy of the PDB):

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle