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View Structure Prediction Details

Protein: exo-1
Organism: Caenorhabditis elegans
Length: 639 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for exo-1.

Description E-value Query
Range
Subject
Range
gi|114573434 - gi|114573434|ref|XP_001160776.1| PREDICTED: exonuclease 1 isoform 1 [Pan troglodytes]
313.0 [0..1] [638..1]

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Predicted Domain #1
Region A:
Residues: [1-374]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MGISGLLPFV KNACRKGNIL ELRGKSVAID VSCLLHRGLT GCMDKIHMGE ETQSYVNYVN  60
   61 KYVKELLGMG CHVVMVFDGR PLPAKKGTNE ERRELREKRK EHAEMLLAKG LEREARDTYR 120
  121 LATSISADIV ENTIQYFRSM TNVDIVVAPY EADAQLAYLV QEKLVDAVIT EDSDLIVFGC 180
  181 EMIYFKWQSA TGECSVYEKC NLKNCFTGEL GGDKFDFVKF RRICILSGCD YLQAGLPGVG 240
  241 LSTAAKFFSM TSIKDLRTLL RKVPSYLKNP KLKEHVNDEF IRNFEKAENT FKHQIVFDPR 300
  301 ERCQKPLTPY PKEVLMTGVD DLEEVIDLDS PKKTAPSSKS FAYAGTASTQ RIAIRLALGN 360
  361 PENKSSIDDQ FLLV

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 62.221849
Match: 1ul1X
Description: Crystal structure of the human FEN1-PCNA complex
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
catalytic activity 0.845290320008287 bayes_pls_golite062009
hydrolase activity 0.31554871338907 bayes_pls_golite062009
hydrolase activity, acting on ester bonds 0.12799711467808 bayes_pls_golite062009
nuclease activity 0.0878151841480506 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [375-479]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 QPTPEWSVWG LRYESKGSTL DKISKQKELE ATQCGGAFKL DSPSVKRVKV ASKTTPNDDE  60
   61 DDIVKQFMAD IEKEKKAIKK RKNAPQVDYN ADVLLKKYAE PPPEK

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [480-639]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 RQKILEVIDD DFSEFFQEKV KENTKESVAE EKVENSNEEL KPPPILRKAV STPDSARKTH  60
   61 KFQSPLLNHQ NSAPPSLPDR KPAQTSKYFS KPTSENGVPK TKNPFRCPAF VKPTQKVEEK 120
  121 IEKTTILAAL EENSVPMPSS NTTYRFVGFK SAGLRRKSKQ 

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle