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View Structure Prediction Details

Protein: zyg-1
Organism: Caenorhabditis elegans
Length: 706 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for zyg-1.

Description E-value Query
Range
Subject
Range
gi|73964111 - gi|73964111|ref|XP_868650.1| PREDICTED: similar to MAP/microtubule affinity-regulating kinase 3 isof...
408.0 [0..2] [624..45]

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Predicted Domain #1
Region A:
Residues: [1-318]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSGGKSGSRL SAYSHLKEIG KGGFGVVYAA QRENGEKVAI KRIDKKVPKN RVWTEIQTMK  60
   61 ELKKSKYVVE FYEDFVEDGY TYIVMELCEG GSLQAYVREH GALDDATAVH VLRQLISAVS 120
  121 FMHRVNVIHR DLSAGNVFIK DSKKKKMTVK LGDFGLATTL GRGETTCTIV GTPGFIAPQV 180
  181 YDQEYTQSAD VYSLGAVLYT MLTARNPPPK GLPPTCGMSP NAARLVEQMM DTDAKKRIPL 240
  241 TQIVLSEFMY ENTNENAVIF SREHSRDGRR QRSREPVRSS RDDRSRDGRA LIRSSSQPAH 300
  301 SGRAPLSNRP IHDRMPST

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 78.39794
Match: 2qnjA
Description: No description for 2qnjA was found.

Predicted Domain #2
Region A:
Residues: [319-387]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SSRGFDSERG RERDRDSGRG TVPPSREDRN RSQLWPIRMD RLEGQRVCTA GGRYIVELDT  60
   61 RCRFEVAAQ

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [388-606]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GNFVKRILIV EVDEMVQTVY VHRIPDRTVR GRNGEEELIT LTNNPFVYTS YSQMPKEVQN  60
   61 DYMRLQKMVA VTISGRVAKV TFRRPSQFPD AQAQLMENGD LRIKLPRSVI VRKMDNGEIF 120
  121 NCIDGIATQK QAVSGITLTK VNEVYKYLIR FEQCLNGMDR GMVCFPIVFS AGTNMVGSSP 180
  181 SSLMPSGSSQ TSRFPFSNLS NNQPSLVPHS APFLTKPTS

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #4
Region A:
Residues: [607-706]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SQRASSANVQ RRVSTDENSS PSVAPSKYKI KIDPTTQKVR SIQATDGRVL RCSTSKADQF  60
   61 IFTDPAIRPD DQRFMRTDRV PDRASEMLHT LCERMRKLHQ 

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 25.522879
Match: 1mbyA
Description: Sak kinase Polo domain
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
binding 1.83279362489885 bayes_pls_golite062009
protein binding 1.15687168153762 bayes_pls_golite062009
protein serine/threonine kinase activity 0.100678873605081 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle