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View Structure Prediction Details

Protein: cas-2
Organism: Caenorhabditis elegans
Length: 457 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for cas-2.

Description E-value Query
Range
Subject
Range
gi|50733649 - gi|50733649|ref|XP_418936.1| PREDICTED: similar to adenylyl cyclase-associated protein 2; 2810452G09...
694.0 [0..1] [456..1]

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Predicted Domain #1
Region A:
Residues: [1-235]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MDPSVVSRLE NVANRTENIL LKYDSNKKET PVDATPQIIN LYDDAICENL VSFYDLSAKI  60
   61 GGDLNRLGCM TRSLFFTHRY FLWIACGRKK ADNDEFATLV NDLSKEIVAF SDFKEKNRKS 120
  121 EFYNHICGLE AAVGGFGWVA EPKTPAPFIK DAIDTSVFYL NRILMEHKGK NDFHSEWAKS 180
  181 IKELMLSLHE YVRQHHTTGL VWNSDPGATP MCNRKSGGAP TPPPPPPPPI SLIAP

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 64.221849
Match: 1tjfA
Description: The crystal structure of the N-terminal domain of CAP indicates variable oligomerisation
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
actin binding 5.81884714997094 bayes_pls_golite062009
cytoskeletal protein binding 4.39652693178112 bayes_pls_golite062009
adenylate cyclase binding 1.89694035952868 bayes_pls_golite062009
binding 1.8340549733034 bayes_pls_golite062009
enzyme binding 1.53072876683435 bayes_pls_golite062009
protein binding 0.871734119777931 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [236-298]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SKPSGVGALL ESLNTGLSAT SRLKKVTPEM QTHKNPVLRE VNGQMNRKTE ERKVSENKKP  60
   61 EKI

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [299-457]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 HESSIFWDGK IWKVDHQVGN KNAVVEVTDK KESIYIYKCN DSIIKIKGKA NAITLDGCRK  60
   61 TSVVFDGLVA QCEIINCQSI QIQTLGELPT VSIQKTDGCH IYLSRDALNA QIVASKSSEM 120
  121 NISAMLEDGD DEYTEMALPE QFMTKIVGKK LVTVASEIV

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 73.09691
Match: 1k8fA
Description: C-terminal domain of adenylylcyclase associated protein
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
actin binding 4.94933252861141 bayes_pls_golite062009
cytoskeletal protein binding 4.21664682046338 bayes_pls_golite062009
actin monomer binding 2.04365563273836 bayes_pls_golite062009
binding 1.57578562719958 bayes_pls_golite062009
adenylate cyclase binding 0.947630973686921 bayes_pls_golite062009
enzyme binding 0.705135358375 bayes_pls_golite062009
protein binding 0.651719649953198 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle