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View Structure Prediction Details

Protein: sma-3
Organism: Caenorhabditis elegans
Length: 393 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for sma-3.

Description E-value Query
Range
Subject
Range
gi|73977821 - gi|73977821|ref|XP_867274.1| PREDICTED: similar to Mothers against decapentaplegic homolog 1 (SMAD 1...
549.0 [0..1] [393..3]

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Predicted Domain #1
Region A:
Residues: [1-147]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MNGLLHMHGP AVKKLLGWKI GEDEEKWCEK AVEALVKKLK KKNNGCGTLE DLECVLANPC  60
   61 TNSRCITIAK SLDGRLQVSH KKGLPHVIYC RVWRWPDISS PHELRSIDTC SYPYESSSKT 120
  121 MYICINPYHY QRLSRPQGLN SSMPSPQ

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 55.39794
Match: 1ozjA
Description: Crystal structure of Smad3-MH1 bound to DNA at 2.4 A resolution
Matching Structure (courtesy of the PDB):

Predicted Domain #2
Region A:
Residues: [148-393]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PISSPNTIWQ SSGSSTASCA SSPSPSVFSE DGGEVQVHQR PPPFRHPKSW AQITYFELNS  60
   61 RVGEVFKLVN LSITVDGYTN PSNSNTRICL GQLTNVNRNG TIENTRMHIG KGIQLDNKED 120
  121 QMHIMITNNS DMPVFVQSKN TNLMMNMPLV KVCRIPPHSQ LCVFEFNLFF QMLEQSCNDS 180
  181 DGLNELSKHC FIRISFVKGW GEDYPRQDVT STPCWLELRL NVPLAYIDQK MKQTPRTNLM 240
  241 EPNSMT

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 91.522879
Match: 1khuA
Description: Smad1
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
binding 2.11808492882744 bayes_pls_golite062009
protein binding 1.57677875769005 bayes_pls_golite062009
transforming growth factor beta receptor, cytoplasmic mediator activity 0.20688121694899 bayes_pls_golite062009
transmembrane receptor protein serine/threonine kinase signaling protein activity 0.17825540288715 bayes_pls_golite062009
signal transducer activity 0.15088578328411 bayes_pls_golite062009
molecular transducer activity 0.15088578328411 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle