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View Structure Prediction Details

Protein: cas-1
Organism: Caenorhabditis elegans
Length: 495 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for cas-1.

Description E-value Query
Range
Subject
Range
gi|50733649 - gi|50733649|ref|XP_418936.1| PREDICTED: similar to adenylyl cyclase-associated protein 2; 2810452G09...
675.0 [0..1] [494..1]

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Predicted Domain #1
Region A:
Residues: [1-216]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSTQEDFLKR LESVTSRLEA IAGQKPALAP KPTNLGGPSA SAAASAGDSG EVPAHVRAYD  60
   61 DAIEEPLANW SKLTDQLGGD LAAVKPKVLA MFASMRNYLW SAAGKSEPSA EEAQKMLTPV 120
  121 INLLGEINNF KDTKRKTPHW NHLNSVAEAL PALGWVTVKK TPAPYVKEFI EAAQFYINPI 180
  181 LREFKETDPR HVEWTKAWKA VFEEMQKFVR QVHTTG

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 62.522879
Match: 1tjfA
Description: The crystal structure of the N-terminal domain of CAP indicates variable oligomerisation
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
actin binding 1.59850944021401 bayes_pls_golite062009
cytoskeletal protein binding 1.08859857656487 bayes_pls_golite062009
binding 0.923764328759134 bayes_pls_golite062009
enzyme binding 0.47575292047999 bayes_pls_golite062009
protein binding 0.153255883232138 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [217-338]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LVWNSAPGAA PDASASAPSA AAPSAPKAPA GPGGPPPPPP PPPADFFANI APPPVDADKA  60
   61 SRDALFASLN QGEGVTSRLK KVTADMQTHK NPNLRGTAVV PAAGASQGGS SPAKPAAPVR 120
  121 KP

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [339-495]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PHKELENGKQ WIVEYFVNDP NIVLDVADKK QTVYIYRCEN SVIKVNGKAN SITLDGCKKT  60
   61 SVVFDALVAQ CETVNCQSVQ IQTLGELPTL SIQKTDGCQV YLSKVAQGCE IVTSKSSEMN 120
  121 ISVQTNDDGD YSEFPVPEQF KTTFVNGKLV TVVSDIC

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 74.221849
Match: 1k8fA
Description: C-terminal domain of adenylylcyclase associated protein
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
cytoskeletal protein binding 0.90871846524713 bayes_pls_golite062009
actin binding 0.72899481885448 bayes_pls_golite062009
binding 0.665494982655313 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle