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View Structure Prediction Details

Protein: isp-1
Organism: Caenorhabditis elegans
Length: 276 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for isp-1.

Description E-value Query
Range
Subject
Range
gi|39587482, gi|... - gi|39587482|emb|CAE58420.1| Hypothetical protein CBG01551 [Caenorhabditis briggsae], gi|187038132|em...
gi|157758009 - gi|157758009|ref|XP_001671348.1| Hypothetical protein CBG01551 [Caenorhabditis briggsae AF16]
232.0 [0..1] [276..1]
gi|109099172, gi... - gi|109099174|ref|XP_001101289.1| PREDICTED: ubiquinol-cytochrome c reductase, Rieske iron-sulfur pol...
218.0 [0..1] [274..2]
gi|57036706 - gi|57036706|ref|XP_533711.1| PREDICTED: similar to ubiquinol-cytochrome c reductase, Rieske iron-sul...
216.0 [0..1] [273..2]
gi|47155579, gi|... - gi|47155579|ref|NP_998251.1| ubiquinol-cytochrome c reductase, Rieske iron-sulfur polypeptide 1 [Dan...
215.0 [0..1] [274..2]
UCRI_CHLAE - Cytochrome b-c1 complex subunit Rieske, mitochondrial OS=Chlorocebus aethiops GN=UQCRFS1 PE=3 SV=1
215.0 [0..1] [273..2]
gi|45768728 - gi|45768728|gb|AAH67832.1| Ubiquinol-cytochrome c reductase, Rieske iron-sulfur polypeptide 1 [Homo ...
215.0 [0..1] [274..2]
UCRI_THEGE - Cytochrome b-c1 complex subunit Rieske, mitochondrial OS=Theropithecus gelada GN=UQCRFS1 PE=3 SV=1
215.0 [0..1] [274..2]
UCRI_MOUSE - Cytochrome b-c1 complex subunit Rieske, mitochondrial OS=Mus musculus GN=Uqcrfs1 PE=1 SV=1
214.0 [0..1] [273..2]
UCRI_PONPY - Cytochrome b-c1 complex subunit Rieske, mitochondrial OS=Pongo pygmaeus GN=UQCRFS1 PE=3 SV=1
214.0 [0..1] [274..2]

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Predicted Domain #1
Region A:
Residues: [1-276]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MASLARSGGF AVKVISGSQQ HVNFVAATPA ADNVAAFRDV PAEFSTAEAR QAAVSHSTGG  60
   61 VFTNGLAVKG INVTSRRLAH TDVTFPDMSN YRRDSTKNTQ VPARDTEDQR RALPTALYYG 120
  121 AGGVLSLWAG KEVVQTLVSY KAMAADQRAL ASIEINMADI PEGKTKTFEW RGKPVFVKHR 180
  181 TKAEIAKEKA VPVADLRHPQ HDDERVQKDE WSVVIGVCTH LGCVPIADAG DYGGYYCPCH 240
  241 GSHYDASGRI RKGPAPLNLH VPAYSFKDAT IVIGSS

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 47.221849
Match: 1bccE
Description: ISP subunit of the mitochondrial cytochrome bc1-complex, watersoluble domain; Iron-sulfur subunit (ISP) of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase), transmembrane region
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
ubiquinol-cytochrome-c reductase activity 12.5243667017255 bayes_pls_golite062009
oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor 12.5243667017255 bayes_pls_golite062009
oxidoreductase activity, acting on diphenols and related substances as donors 9.125468664417 bayes_pls_golite062009
hydrogen ion transmembrane transporter activity 6.56410033542443 bayes_pls_golite062009
monovalent inorganic cation transmembrane transporter activity 6.40889163290296 bayes_pls_golite062009
oxidoreductase activity 6.05060612159037 bayes_pls_golite062009
inorganic cation transmembrane transporter activity 5.79350583896014 bayes_pls_golite062009
cation transmembrane transporter activity 5.52425708699797 bayes_pls_golite062009
ion transmembrane transporter activity 5.31511996363681 bayes_pls_golite062009
electron carrier activity 5.20213585732279 bayes_pls_golite062009
substrate-specific transmembrane transporter activity 4.88364619884033 bayes_pls_golite062009
substrate-specific transporter activity 4.66567624087954 bayes_pls_golite062009
binding 0.859614464562991 bayes_pls_golite062009
catalytic activity 0.746741393172769 bayes_pls_golite062009
iron-sulfur cluster binding 0.71220774812099 bayes_pls_golite062009
metal cluster binding 0.71220774812099 bayes_pls_golite062009
protein binding 0.400602154675453 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle