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View Structure Prediction Details

Protein: tyr-4
Organism: Caenorhabditis elegans
Length: 751 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for tyr-4.

Description E-value Query
Range
Subject
Range
gi|187036213, gi... - gi|39595381|emb|CAE60419.1| Hypothetical protein CBG04025 [Caenorhabditis briggsae], gi|187036213|em...
gi|157746119 - gi|157746119|ref|XP_001668156.1| Hypothetical protein CBG04025 [Caenorhabditis briggsae AF16]
352.0 [0..18] [751..19]

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Predicted Domain #1
Region A:
Residues: [1-96]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MRFLIPIIFT TLPLCLQAQE DPCASAPSEA AKIMCKQIHR WDDGARAASK KKKIALPPGM  60
   61 AKGMAAEFAP IASNIYQCMD LPCLCSYLRG TASGNG

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [97-326]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 CTLPNGRPLQ KSVRKEYRTL TDDERNRLHA AFRALKNNGE YERIGRIHSQ MSAAGGAHSG  60
   61 PAFLPWHREF VKRVEFALRQ VDPTVNLPYW DSTLDSRLPR PADTIMFSDY LMGSTGLVND 120
  121 GPFTNWRTLA GRAQILRAVG AQGAPLSQND IDFVMRQTQI DQVLSFTAPQ QGCPYRTDFN 180
  181 CLEYTHGNVH IFVGGDMFDT ATSSNDPSFF LHHAFIDFVW EEWRLARQSR 

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 61.30103
Match: 1wx2A
Description: Crystal Structure of the oxy-form of the copper-bound Streptomyces castaneoglobisporus tyrosinase complexed with a caddie protein prepared by the addition of hydrogenperoxide
Matching Structure (courtesy of the PDB):

Predicted Domain #3
Region A:
Residues: [327-751]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ADREIAFPPD NQLCASAQHF GASPMQPFSP MRNIDGLSNK YTDNLYSYAP RPTCQAGGDC  60
   61 GSKFLFCDTS TGAARCVSRI RPGSQCGQFR VNPCFSGICQ NGVCVLSSTA PRPTPAPTTP 120
  121 TPQNPVQSQE SCFNENQCCA SWAASGECSR NTAYMNEWCK ASCGVCKPKY RLADDCTDRH 180
  181 TQCSSWSRSG ECTKNQLWMT ENCRKSCNKC GRSRAQECGG GGTTVTTTTP APAQQCDNSD 240
  241 GCFNENVCCA VWGLMGECRK NTRYMACNCR VSCGHCYPED YNYGSCVDYH RSCAGWARVG 300
  301 ECQKNPWMAE NCRSSCNSCY TQSELRRMCG TTAGSVAPVA QVRQTNPSRQ PPRGGWGRDD 360
  361 FGDNGGWGGN GGGGWGNNDP WGGSRWGGGR GGWGGGGWGG GGWGKRSIRA ANASISMPSF 420
  421 DPDLL

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 13.522879
Match: 1n7dA
Description: Low density lipoprotein (LDL) receptor YWTD domain; Low density lipoprotein (LDL) receptor, different EGF domains; Ligand-binding domain of low-density lipoprotein receptor
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
binding 0.286076792172079 bayes_pls_golite062009
protein binding 0.14494900666454 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle