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View Structure Prediction Details

Protein: obr-4
Organism: Caenorhabditis elegans
Length: 676 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for obr-4.

Description E-value Query
Range
Subject
Range
gi|114556550 - gi|114556550|ref|XP_001143249.1| PREDICTED: oxysterol-binding protein-like protein 9 isoform 22 [Pan...
gi|119627219, gi... - gi|56203703|emb|CAI22217.1| oxysterol binding protein-like 9 [Homo sapiens], gi|55962539|emb|CAI1484...
488.0 [0..1] [673..23]

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Predicted Domain #1
Region A:
Residues: [1-107]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MEGPLSKWTN MVHGWQYRWF KIENDTLLYY TSREKMLKGQ QRGQIRLTGA VVGIDGENNS  60
   61 LFTITVEGKT FHMQGRDLRE RNQWVRILEN SIRASSGYAK NVSVGTT

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 15.39794
Match: 2d9xA
Description: No description for 2d9xA was found.

Predicted Domain #2
Region A:
Residues: [108-268]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PSQHFKQRTE EANEFLKTLV EKVKALEQLK SGERAVDEKK TIDSLIAASN NLTNNVKHAI  60
   61 IYLQMAQARL DPNMKTEKLM FTHPDLNEKP SSRETPGTVS DSTQTSTDKP ISGIQHLDHL 120
  121 KPQRAESYAS SDEEEFYDAD EELIDLDNFE SEKSGQESGD S

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [269-676]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NRTSDAAIMS SDEDGYDFGD SNEDFDEIYN NAEEHDIGNV QQDHGSVLMH LLSQVSVGMD  60
   61 LTKVTLPTFI LERRSLLEMY ADFFAHPDLF IATNGNDSAE KRMIAVVRYY LNSFYAARKS 120
  121 GVAKKPYNAI LGETFRCRYS VPNSSLSGKK TESGPWPGSD EKQLTFIAEQ VSHHPPISAF 180
  181 YAEMPSEGIS FNAHIYTKSS FLGLSIGVAS IGEGILTLHN YGDEQYTITF PSGYGRSIMS 240
  241 TPWFEFGGKV KVECEKTGYR ADIEFLTKPF FGGKPHRIQG SICRDGAKKP VLTLRGEWNG 300
  301 TMYAKTQNGE EYVFVDVKAK PEVKKECVPV MQQGKRESRR LWRHVTAALL RNRIQTATTS 360
  361 KRFIEQRQRK EAKERLESGE KWTPLLFDTT DKDGEWMYKQ KFGVRKAV

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 71.221849
Match: 1zhtA
Description: Structure of yeast oxysterol binding protein Osh4 in complex with 7-hydroxycholesterol
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
oxysterol binding 5.62675037461468 bayes_pls_golite062009
sterol binding 4.18891468109664 bayes_pls_golite062009
3.02967613614595 bayes_pls_golite062009
steroid binding 2.54679035876403 bayes_pls_golite062009
binding 2.53764463034371 bayes_pls_golite062009
phosphoinositide binding 2.2725849852584 bayes_pls_golite062009
phospholipid binding 2.08170907241909 bayes_pls_golite062009
lipid binding 1.8520231230392 bayes_pls_golite062009
phosphatidylinositol-4,5-bisphosphate binding 1.72950454023501 bayes_pls_golite062009
cholesterol binding 0.644339278395346 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle