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View Structure Prediction Details

Protein: ran-3
Organism: Caenorhabditis elegans
Length: 569 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for ran-3.

Description E-value Query
Range
Subject
Range
gi|68355286 - gi|68355286|ref|XP_685556.1| PREDICTED: similar to hect domain and RLD 4 (predicted) [Danio rerio]
386.0 [0..18] [565..32]

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Predicted Domain #1
Region A:
Residues: [1-111]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSTAEQRMDT SEVELPNDNV NEQGNKTPRA DQPESSASGA RNHGEDEEVT EQVELAAMET  60
   61 EASDSIVDNV PKTPRRAGRP KKLPSTSTAA AESAVTPGKR GRKRKGSESV N

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [112-569]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 TTINSTMNST LNEPKTPGRK QAKLVAPLLT YDLFAPSIIG DRVLSCGEGE ALGHPGRTTT  60
   61 KKPRKVDIFE EEGLKPLQAV AGGVHSAVLT SEGEVYMCGI NEKGTVPAEG VEKEGSTDEF 120
  121 AKVKFEEDIE KEGKIVMLAA GASFTAALTD QGSVIAWGNL RNSNGNVDVH PLLHKMQEAP 180
  181 VVIVHQAKRK IVKIAAGENH LVMLDEKGCL LTFGDGEMGQ LGRSSRTKTI RSKYMCDESG 240
  241 DHLLVPLRFK HKGKFFDVVA KNVFASGFWT IVHGEDGKYY AFGLNNYAQL GIKVDEADVG 300
  301 QDGQDNRELR VFLPAEAPAF GAERTFVNIE GVQHVVILGS DGKVFAMGKN TDNALGLGNW 360
  361 TGKDDQQHWL YDTIQEIEFD SKIVGVSAKL ATSIAWSEDG TAYAWGFDTT GQLGLGLKDE 420
  421 DEKMVSKPEE ISSAHLDGYS IIGASISDQH TLIIAKKN

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 87.221849
Match: 1a12A
Description: Regulator of chromosome condensation RCC1
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
Ran guanyl-nucleotide exchange factor activity 1.99390987036621 bayes_pls_golite062009
binding 1.94765972306941 bayes_pls_golite062009
protein binding 0.568399753749593 bayes_pls_golite062009
nucleoside-triphosphatase regulator activity 0.290397858094315 bayes_pls_golite062009
GTPase regulator activity 0.284277561587354 bayes_pls_golite062009
catalytic activity 0.261970921089142 bayes_pls_golite062009
guanyl-nucleotide exchange factor activity 0.185600765994903 bayes_pls_golite062009
enzyme regulator activity 0.169745277614311 bayes_pls_golite062009
small GTPase regulator activity 0.0831999559001558 bayes_pls_golite062009
Ras guanyl-nucleotide exchange factor activity 0.0619395994301855 bayes_pls_golite062009
ligase activity 0.0362651353144661 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle