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View Structure Prediction Details

Protein: its8
Organism: Schizosaccharomyces pombe
Length: 935 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for its8.

Description E-value Query
Range
Subject
Range
MCD4_NEUCR - GPI ethanolamine phosphate transferase 1 OS=Neurospora crassa GN=mcd-4 PE=3 SV=1
MCD4_NEUCR - GPI ethanolamine phosphate transferase 1 OS=Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS ...
650.0 [0..5] [927..9]
MCD4_GIBZE - GPI ethanolamine phosphate transferase 1 OS=Gibberella zeae (strain PH-1 / ATCC MYA-4620 / FGSC 9075...
MCD4_GIBZE - GPI ethanolamine phosphate transferase 1 OS=Gibberella zeae GN=MCD4 PE=3 SV=1
639.0 [0..5] [927..9]
gi|5631308, gi|7... - gi|7305383|ref|NP_038812.1| phosphatidylinositol glycan anchor biosynthesis, class N [Mus musculus],...
624.0 [0..4] [922..3]
gi|39952467, gi|... - gi|39952467|ref|XP_363911.1| hypothetical protein MG01837.4 [Magnaporthe grisea 70-15], gb|EAA56186....
610.0 [0..37] [926..10]
gi|20306653 - gi|20306653|gb|AAH28363.1| Phosphatidylinositol glycan anchor biosynthesis, class N [Homo sapiens]
606.0 [0..4] [922..3]
gi|109498448, gi... - gi|209954806|ref|NP_001094054.1| phosphatidylinositol glycan, class N [Rattus norvegicus], gi|149037...
605.0 [0..4] [922..3]
gi|159122181 - gi|159122181|gb|EDP47303.1| GPI-anchor biosynthetic protein (Mcd4), putative [Aspergillus fumigatus ...
MCD4_ASPFU - GPI ethanolamine phosphate transferase 1 OS=Aspergillus fumigatus GN=mcd4 PE=2 SV=1
MCD4_ASPFU - GPI ethanolamine phosphate transferase 1 OS=Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS...
605.0 [0..5] [928..9]
MCD4_ASPOR - GPI ethanolamine phosphate transferase 1 OS=Aspergillus oryzae GN=mcd4 PE=3 SV=1
MCD4_ASPOR - GPI ethanolamine phosphate transferase 1 OS=Aspergillus oryzae (strain ATCC 42149 / RIB 40) GN=mcd4 ...
604.0 [0..5] [928..9]

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Predicted Domain #1
Region A:
Residues: [1-416]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MFGRLLLLGI LFHVVFLKSI FDIYFVTPLI HGMKQYSAGE APAKRLFLIV GDGLRPDKLL  60
   61 QPHSEKVIGE EQTYAAPFLR SIIQNNGTFG VSHTRVPTES RPGHVALIAG FYEDVSAVTK 120
  121 GWKKNPVNFD SVFNQSRHTY SFGSEDILPM FSEGASDPSR VDTFMYSSEL EDFSSNGIVL 180
  181 DEWVFDRLDE LLAQSLEDKE LWDMLHRDKI VFFLHLLGID TIGHNKHPDS VEYVENIQYI 240
  241 DGKIQELVDK MNNYYNNDGA SSWVFTADHG MSDFGSHGDG NLDNTRTPII AWGAGIQSPT 300
  301 HEKNYGHDEY SLPWNLTEIK RIDIQQADIA ALMSYLVGLN FPVNSVGQIP LDYLDCSSRR 360
  361 KAEVALMNAL EIGEQYNLKS ASKDQTSIFF RPYSPLRNYT EVQASFYNSV IADIES

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 41.0
Match: 1e1zP
Description: Arylsulfatase A
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
hydrolase activity 3.93573675436765 bayes_pls_golite062009
hydrolase activity, acting on ester bonds 2.50752017262291 bayes_pls_golite062009
catalytic activity 2.31328968099128 bayes_pls_golite062009
sulfuric ester hydrolase activity 2.02024402809818 bayes_pls_golite062009
phosphatase activity 1.06063475304592 bayes_pls_golite062009
binding 0.988674249789348 bayes_pls_golite062009
phosphoric ester hydrolase activity 0.861123866751778 bayes_pls_golite062009
arylsulfatase activity 0.668750969117077 bayes_pls_golite062009
protein binding 0.392789852918493 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [417-481]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GEYEIAIEHC FHFSQTVLSG LRYLQRYDWL LLRSIVFFGY LSWIGYVICF VFSLNIEPSS  60
   61 KIVKP

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [482-638]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 VSVVKRVAFN IPFLLICIFF YIQSSPPFYY GYALFPTIFL QLIHSIFPNT KLGFKNFLTV  60
   61 AKQKHGFSLL KILFISLCIL CLLQFIVYSY FHREGFSVIL MGLAAWPWLL HADYAFSHKT 120
  121 ISVSWSVLTS LLCFFTILPV NKKESLLFIF AGGFAMS

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #4
Region A:
Residues: [639-785]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 VAGVFYILYR RNQAFQYSST VTNKQLVLQV LIIMATVPVT LKIADSLQRN IAIPPILRLV  60
   61 AFGLFITSYI IPSHHIRSCK HYFLDRLAIL FLTFSPTMCM LSISFEALFY VVLFITLGLW 120
  121 MELETELQKY TEQLHPEYSR KKDAKFH

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #5
Region A:
Residues: [786-935]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LSLSHIRISL FFYIFINVAF FGTGNVASLS TFALDSVKRF IPVFNPVTQG ALLMYTILVP  60
   61 FIALSAAFGI MNKRLGGIQQ VTFFLAVGMA DIVTINFFYL VKDEGSWKDI GVSISHFCIS 120
  121 NFLILFITAL EHASAILCKN ITYTIHEKVN 

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle