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View Structure Prediction Details

Protein: SPAC23H4.15
Organism: Schizosaccharomyces pombe
Length: 783 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for SPAC23H4.15.

Description E-value Query
Range
Subject
Range
gi|73997953 - gi|73997953|ref|XP_857393.1| PREDICTED: similar to Ribosome biogenesis protein BMS1 homolog isoform ...
832.0 [0..4] [780..5]
gi|7243183 - gi|7243183|dbj|BAA92639.1| KIAA1401 protein [Homo sapiens]
814.0 [0..2] [779..52]
gi|42549941, gi|... - gi|46117122|ref|XP_384579.1| hypothetical protein FG04403.1 [Gibberella zeae PH-1], gi|42549941|gb|E...
814.0 [0..1] [782..5]
gi|28918034, gi|... - gi|7801047|emb|CAB91443.1| conserved hypothetical protein [Neurospora crassa], gi|32414925|ref|XP_32...
gi|85082636 - gi|85082636|ref|XP_956952.1| hypothetical protein NCU01503 [Neurospora crassa OR74A]
814.0 [0..3] [783..8]
TSR1_MOUSE - Pre-rRNA-processing protein TSR1 homolog OS=Mus musculus GN=Tsr1 PE=1 SV=1
813.0 [0..2] [779..3]
gi|109112682 - gi|109112682|ref|XP_001086730.1| PREDICTED: similar to Temporarily Assigned Gene name family member ...
803.0 [0..2] [779..3]

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Predicted Domain #1
Region A:
Residues: [1-76]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAHHHRSTFK AKKPFKSKHA SKSSLKEKYK NEVEPHRSGP KNIVHTSTKA DRRNTAKQIQ  60
   61 LNKRTEVAMN NRIFGG

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

    MCM
Score
SCOP
Match
SCOP Description
View Download 0.609 a.4.5 "Winged helix" DNA-binding domain
View Download 0.599 a.4.5 "Winged helix" DNA-binding domain
View Download 0.430 a.2.3 Chaperone J-domain
View Download 0.394 a.2.3 Chaperone J-domain
View Download 0.371 a.108.1 Ribosomal protein L7/12, oligomerisation (N-terminal) domain
View Download 0.360 a.24.17 Group V grass pollen allergen
View Download 0.354 a.64.1 Saposin
View Download 0.347 a.4.5 "Winged helix" DNA-binding domain
View Download 0.313 d.58.7 RNA-binding domain, RBD
View Download 0.303 a.64.1 Saposin

Predicted Domain #2
Region A:
Residues: [77-285]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KNGAPKVITI VPLCNNVDSW NVLTNLLRSI DPEASLPKFD KDSISYSTTI DRFKQNLLFL  60
   61 LPKREFYSLI DACKVSDYVI FVLSAVQEVD EFGELIVRTT QGQGISSVLS MVHDLSEVDS 120
  121 LKTRNEVKKS LQSFMNFFFS DQERVFAADV SQDALNVMRA LCTSHPRGIH WRDSRSYLLS 180
  181 QEISYSNGNL LVRGIVRGKG LDPNRLIHI

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 4.30103
Match: 1kk0A
Description: Initiation factor eIF2 gamma subunit, domain II; Initiation factor eIF2 gamma subunit; Initiation factor eIF2 gamma subunit, N-terminal (G) domain
Matching Structure (courtesy of the PDB):

Predicted Domain #3
Region A:
Residues: [286-340]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 QGFGDFAINR IYEAPQGIQN SRGISMDEDT NLTGGLVELC SPTQEQDSLE SLGPI

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

    MCM
Score
SCOP
Match
SCOP Description
View Download 0.637 a.4.1 Homeodomain-like
View Download 0.594 a.4.1 Homeodomain-like
View Download 0.586 a.52.1 Bifunctional inhibitor/lipid-transfer protein/seed storage 2S albumin
View Download 0.505 a.4.1 Homeodomain-like
View Download 0.463 a.4.1 Homeodomain-like
View Download 0.444 a.4.5 "Winged helix" DNA-binding domain
View Download 0.431 a.8.1 Bacterial immunoglobulin/albumin-binding domains
View Download 0.416 a.4.1 Homeodomain-like
View Download 0.391 a.4.5 "Winged helix" DNA-binding domain
View Download 0.282 a.16.1 S15/NS1 RNA-binding domain
View Download 0.242 a.4.1 Homeodomain-like

Predicted Domain #4
Region A:
Residues: [341-516]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 IDDMDTDMDS EVGKEASRGV RLDDFYYFDD EEEPVAVAKR VPKGTSTYQA TWIPDEDEES  60
   61 DQYSDVEDTE VIIEDQDNQE ISNHVAEEKI DSDEEETIDD AKSEMFVDLS EEEEVRQYEE 120
  121 YRKKQKELQE ELEFPDEVEL QPNELARERF KKYRGLRSLY TSQWDADEYD PNEPRE

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #5
Region A:
Residues: [517-576]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 WRQLFKFENY RNLKNKFLKQ PFIGEAKPGK AVYVELRNVP IEIFEYYNKP WNLLVLYSLL  60
   61 

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

    MCM
Score
SCOP
Match
SCOP Description
View Download 0.530 a.8.1 Bacterial immunoglobulin/albumin-binding domains
View Download 0.520 a.4.11 RNA polymerase subunit RPB10
View Download 0.496 a.144.1 PABC (PABP) domain
View Download 0.460 a.4.5 "Winged helix" DNA-binding domain
View Download 0.415 a.218.1 Description not found.
View Download 0.415 a.10.2 Description not found.
View Download 0.410 d.11.1 Penicillin-binding protein 2x (pbp-2x), c-terminal domain
View Download 0.383 a.4.1 Homeodomain-like
View Download 0.373 a.4.1 Homeodomain-like
View Download 0.356 d.68.3 SirA-like
View Download 0.213 a.4.1 Homeodomain-like

Predicted Domain #6
Region A:
Residues: [577-712]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 QYENKLTVSQ FTAMQHSEYE EPIESKEELL LQIGPRRFMV RPLYSDPTAS GASNNLQKYH  60
   61 RYLPPKQAVI ASVISPIVFG NVPIIMFKKS SDNSLRLAAT GSYVNCDTNS VIAKRAVLTG 120
  121 HPFKVHKKLV TIRYMF

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

    MCM
Score
GO
Score
GO
Term
SCOP
Match
SCOP Description
View Download 0.378 N/A N/A d.17.4 NTF2-like
View Download 0.338 N/A N/A b.1.10 Clathrin adaptor appendage domain
View Download 0.326 N/A N/A b.1.10 Clathrin adaptor appendage domain
View Download 0.314 N/A N/A d.17.4 NTF2-like
View Download 0.269 N/A N/A c.55.3 Ribonuclease H-like
View Download 0.245 N/A N/A d.17.4 NTF2-like
View Download 0.242 N/A N/A c.55.3 Ribonuclease H-like
View Download 0.227 N/A N/A b.1.10 Clathrin adaptor appendage domain
View Download 0.225 N/A N/A c.51.2 TolB, N-terminal domain
View Download 0.220 N/A N/A d.109.1 Actin depolymerizing proteins
View Download 0.219 N/A N/A d.17.4 NTF2-like
View Download 0.204 N/A N/A c.51.2 TolB, N-terminal domain

Predicted Domain #7
Region A:
Residues: [713-783]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 FNPEDVIWFK PIQLFTKQGR TGYIKEPLGT HGYFKATFNG KITVQDTVAM SLYKRMYPLP  60
   61 CELFKVTDID S

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

    MCM
Score
SCOP
Match
SCOP Description
View Download 0.686 b.34.19 Description not found.
View Download 0.643 d.58.7 RNA-binding domain, RBD
View Download 0.640 d.52.8 Description not found.
View Download 0.637 g.18.1 Complement control module/SCR domain
View Download 0.627 b.38.2 YhbC-like, C-terminal domain
View Download 0.617 b.34.5 Translation proteins SH3-like domain
View Download 0.606 g.18.1 Complement control module/SCR domain
View Download 0.603 b.34.5 Translation proteins SH3-like domain
View Download 0.560 d.10.1 DNA-binding domain
View Download 0.558 d.58.5 GlnB-like
View Download 0.477 d.74.1 Pterin-4a-carbinolamine dehydratase (PCD)/dimerization cofactor of HNF1 (DCoH)
View Download 0.388 b.40.4 Nucleic acid-binding proteins
View Download 0.336 d.9.1 Interleukin 8-like chemokines
View Download 0.323 d.50.1 dsRNA-binding domain-like


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle