YRC Public Data Repository - Protein Structure Prediction

Protein:	ero11
Organism:	Schizosaccharomyces pombe
Length:	467 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for ero11.

Description	E-value	Query Range	Subject Range
gi\|46120528, gi\|... - gi\|46120528\|ref\|XP_385087.1\| hypothetical protein FG04911.1 [Gibberella zeae PH-1], gi\|42551433\|gb\|E...	544.0	[0..18]	[419..22]
gi\|39974341, gi\|... - gi\|39974341\|ref\|XP_368561.1\| hypothetical protein MG00683.4 [Magnaporthe grisea 70-15], gb\|EAA49025....	540.0	[0..16]	[419..31]
ERO1_NEUCR - Endoplasmic oxidoreductin-1 OS=Neurospora crassa GN=ero-1 PE=3 SV=1 ERO1_NEUCR - Endoplasmic reticulum oxidoreductin-1 OS=Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708...	530.0	[0..19]	[419..30]
gi\|73952532 - gi\|73952532\|ref\|XP_546074.2\| PREDICTED: similar to endoplasmic reticulum oxidoreductin 1-Lbeta [Cani...	517.0	[0..22]	[414..322]
ER1A_MOUSE, ERO1... - ERO1-like protein alpha OS=Mus musculus GN=Ero1l PE=2 SV=1, (Q8R180) ERO1-like protein alpha precurs...	510.0	[0..23]	[415..41]
gi\|19924061, gi\|... - gi\|19924061\|ref\|NP_612537.1\| ERO1-like [Rattus norvegicus], gi\|18250366\|gb\|AAL61547.1\| oxidoreductas...	508.0	[0..23]	[415..41]
gi\|50748954 - gi\|50748954\|ref\|XP_421473.1\| PREDICTED: similar to ERO1-like [Gallus gallus]	508.0	[0..22]	[420..194]
gi\|109083588 - gi\|109083588\|ref\|XP_001103965.1\| PREDICTED: ERO1-like isoform 3 [Macaca mulatta]	507.0	[0..23]	[415..41]

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Predicted Domain #1

Region A:
Residues: [1-467]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MIGITKLISI WNAIWNFLLL PEIIISQTDT SSTGIYQMQS KVRSLVPVLT ERSDYFSYYR  60
   61 VNLYRSSCPL WENDNAMCSN QGCAVKSLNE IEIPKVWKKL SDFEPHSKKN DTKCNWKYNP 120
  121 DLDYCYLDNS TSPDEYVYVS LVQNPERFTG YAGDHSAAIW RSIYEQNCFV VDDDDNPSEQ 180
  181 PKSNALFRPN QIPLNLFTEN HDDTSLSPSV ACLEKRMFNR IISGFHASIS THVCQNYYDV 240
  241 EEQRWTQNLD WWRAKVGSFP DRIENIFFNY ALLHQALVQI ATQMKNITSD SSFTFCPTDK 300
  301 DVDWRTHTAF EQLVYHAYQD RHVINREQFF ADEEAKRFKD SFRKHFRDIS RIMDCVGCDK 360
  361 CRLWGKVQIT GYGTALKLLL EPETQLSDLR PEEVVALVNT FDRISHSVEA TFWFSLKAKT 420
  421 NDTLDAIKAL IYKTYRSPSK EILAFFIDQT WYLFYALFFI CNVPRVI

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	111.0
Match:	1rq1A
Description:	Structure of Ero1p, Source of Disulfide Bonds for Oxidative Protein Folding in the Cell
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
oxidoreductase activity, acting on sulfur group of donors	3.04541306149882	bayes_pls_golite062009
thiol oxidase activity	1.56067935587779	bayes_pls_golite062009
binding	1.51315006963036	bayes_pls_golite062009
oxidoreductase activity, acting on sulfur group of donors, oxygen as acceptor	1.31287436426921	bayes_pls_golite062009
protein disulfide oxidoreductase activity	1.25764823859811	bayes_pls_golite062009
unfolded protein binding	1.21113889423637	bayes_pls_golite062009
catalytic activity	1.09506175640279	bayes_pls_golite062009
protein binding	0.524855475418758	bayes_pls_golite062009
disulfide oxidoreductase activity	0.384901602591813	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: