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View Structure Prediction Details

Protein: ero12
Organism: Schizosaccharomyces pombe
Length: 571 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for ero12.

Description E-value Query
Range
Subject
Range
gi|39974341, gi|... - gi|39974341|ref|XP_368561.1| hypothetical protein MG00683.4 [Magnaporthe grisea 70-15], gb|EAA49025....
634.0 [0..45] [536..37]
gi|73952532 - gi|73952532|ref|XP_546074.2| PREDICTED: similar to endoplasmic reticulum oxidoreductin 1-Lbeta [Cani...
613.0 [0..39] [469..312]
gi|46120528, gi|... - gi|46120528|ref|XP_385087.1| hypothetical protein FG04911.1 [Gibberella zeae PH-1], gi|42551433|gb|E...
610.0 [0..45] [539..26]
ERO1A_MOUSE - ERO1-like protein alpha OS=Mus musculus GN=Ero1a PE=1 SV=2
606.0 [0..43] [469..35]
ERO1_NEUCR - Endoplasmic oxidoreductin-1 OS=Neurospora crassa GN=ero-1 PE=3 SV=1
ERO1_NEUCR - Endoplasmic reticulum oxidoreductin-1 OS=Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708...
606.0 [0..10] [506..8]
gi|76656155 - gi|76656155|ref|XP_592198.2| PREDICTED: similar to endoplasmic reticulum oxidoreductin 1-Lbeta [Bos ...
599.0 [0..46] [469..74]
ERO1A_RAT - ERO1-like protein alpha OS=Rattus norvegicus GN=Ero1a PE=1 SV=1
597.0 [0..27] [469..19]

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Predicted Domain #1
Region A:
Residues: [1-473]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MFMWMKIAKG LVGLLILYKN VCQVLCKSGS SVKSGSPWSI KNDGKSIIHD TLNSSYSDIE  60
   61 NLNSRVSPLL FDLTEKSDYM RFYRLNLFNK ECRYNLDDNV ACGSSACNVL VTDEQDVPEV 120
  121 WSSKSLGKLE GFMPELSRQI VETDRSVMEH VDKISQSCLL ERLDDEAHQY CYVDNELDSG 180
  181 CVYVSLLENP ERFTGYSGPH STRIWEMIYN QCLPDSSAPT IDFPALFMQG PLAPPPKPQE 240
  241 QLLKERMDAW TLEQRVFYRV LSGMHSSIST HLCHGYLNQR NGVWGPNLQC FQEKVLNYPE 300
  301 RLENLYFAYA LMQRAIDKLY GHLDSLTFCH DSVLQDSEVR QKIAGLVSLI HNSPKMFDET 360
  361 MLFAGDPSIS TALKEDFREH FKTVSALMDC VGCERCRLWG KIQTNGFGTA LKILFEVSNI 420
  421 EDEVTNFDSR SFSLRLRRSE IVALINTFDR LSRSINFVDD FKQIYSEQHK PAS

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 127.0
Match: 1rq1A
Description: Structure of Ero1p, Source of Disulfide Bonds for Oxidative Protein Folding in the Cell
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
oxidoreductase activity, acting on sulfur group of donors 3.04541306149882 bayes_pls_golite062009
thiol oxidase activity 1.56067935587779 bayes_pls_golite062009
binding 1.51315006963036 bayes_pls_golite062009
oxidoreductase activity, acting on sulfur group of donors, oxygen as acceptor 1.31287436426921 bayes_pls_golite062009
protein disulfide oxidoreductase activity 1.25764823859811 bayes_pls_golite062009
unfolded protein binding 1.21113889423637 bayes_pls_golite062009
catalytic activity 1.09506175640279 bayes_pls_golite062009
protein binding 0.524855475418758 bayes_pls_golite062009
disulfide oxidoreductase activity 0.384901602591813 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [474-571]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 FKRRVLRRIK QLLFSVTPVA LHPFLQKTSS ILVDLYFDFK AEWDNVMLGF RYVFASYLRF  60
   61 PRLFKFVLFS QESPFLNWTS HHLQRYIPKN WFPEVASV

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle