YRC Public Data Repository - Protein Structure Prediction

Protein:	SPAC323.05c
Organism:	Schizosaccharomyces pombe
Length:	231 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for SPAC323.05c.

Description	E-value	Query Range	Subject Range
gi\|89952490, gi\|... - gi\|90022890\|ref\|YP_528717.1\| protein methyltransferase hemK [Saccharophagus degradans 2-40], gi\|8995...	169.0	[0..1]	[219..76]
gi\|34763569, gi\|... - gi\|34763569\|ref\|ZP_00144504.1\| METHYLTRANSFERASE [Fusobacterium nucleatum subsp. vincentii ATCC 4925...	166.0	[0..2]	[227..144]
gi\|71065791, gi\|... - gi\|71065791\|ref\|YP_264518.1\| HemK family modification methylase [Psychrobacter arcticus 273-4], gi\|7...	166.0	[0..1]	[223..79]
gi\|20515121, gi\|... - gi\|20806671\|ref\|NP_621842.1\| rRNA or tRNA methylase [Thermoanaerobacter tengcongensis MB4], gi\|20515... gi\|20806671 - gi\|20806671\|ref\|NP_621842.1\| predicted rRNA or tRNA methylase [Thermoanaerobacter tengcongensis MB4]	163.0	[0..5]	[220..82]
gi\|108463432, gi... - gi\|108759552\|ref\|YP_633065.1\| putative protein methyltransferase HemK [Myxococcus xanthus DK 1622], ...	162.0	[0..1]	[219..78]
gi\|14517939 - gi\|14517939\|gb\|AAK64442.1\|AF377339_3 protoporphyrinogen oxidase HemK [Myxococcus xanthus]	162.0	[0..1]	[219..78]
gi\|152979100, gi... - gi\|75430862\|ref\|ZP_00732883.1\| rRNA or tRNA methylase [Actinobacillus succinogenes 130Z], gi\|7427643...	161.0	[0..2]	[222..78]
gi\|197093706, gi... - gi\|197362229\|ref\|YP_002141866.1\| N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase [S... gi\|56413304, gi\|... - gi\|56413304\|ref\|YP_150379.1\| N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase [Salmo...	161.0	[0..1]	[222..71]
gi\|88701869, gi\|... - gi\|88704042\|ref\|ZP_01101757.1\| protoporphyrinogen oxidase [gamma proteobacterium KT 71], gi\|88701869...	160.0	[0..1]	[216..70]
lcl\|NC_016856.1_... - [gene=hemK] [protein=N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase] [protein_id=Y... gi\|206708521, gi... - gi\|207856718\|ref\|YP_002243369.1\| N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase [S... gi\|224583735, gi... - gi\|224583735\|ref\|YP_002637533.1\| N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase [S... HEMK_SALTY - Protein methyltransferase hemK OS=Salmonella typhimurium GN=hemK PE=3 SV=2 gi\|194443667, gi... - gi\|194443667\|ref\|YP_002041025.1\| protein-(glutamine-N5) methyltransferase, release factor-specific [... gi\|194735200, gi... - gi\|194735200\|ref\|YP_002114805.1\| protein-(glutamine-N5) methyltransferase, release factor-specific [... gi\|197243898, gi... - gi\|197265643\|ref\|ZP_03165717.1\| protein-(glutamine-N5) methyltransferase, release factor-specific [S... gi\|197939950, gi... - gi\|198245434\|ref\|YP_002215370.1\| protein methyltransferase HemK [Salmonella enterica subsp. enterica... gi\|161363093, gi... - gi\|161613729\|ref\|YP_001587694.1\| N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase [S... gi\|167993218, gi... - gi\|205328672\|gb\|EDZ15436.1\| protein methyltransferase HemK [Salmonella enterica subsp. enterica sero... gi\|197289229, gi... - gi\|197289229\|gb\|EDY28596.1\| protein-(glutamine-N5) methyltransferase, release factor-specific [Salmo... gi\|205342641, gi... - gi\|205342641\|gb\|EDZ29405.1\| protein-(glutamine-N5) methyltransferase, release factor-specific [Salmo... PRMC_SALTY - Release factor glutamine methyltransferase OS=Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 7... PRMC_SALTY, HEMK... - Release factor glutamine methyltransferase OS=Salmonella typhimurium GN=prmC PE=3 SV=2, Protein meth... gi\|62127972, gi\|... - gi\|62180339\|ref\|YP_216756.1\| N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase [Salmo...	160.0	[0..1]	[222..71]

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Predicted Domain #1

Region A:
Residues: [1-231]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MLSTPVTSQL RLKEFQDVYE PAEDTFALLD ALEKDAKKLR QMAEMKNLLT AEIGCGSGCA  60
   61 SSFLKSGILK NKPIVHFMSD ISNSACRASK ITALNNRELY KDDNGLFITV QTSFLDGIRL 120
  121 GNGVDILIFN PPYVPTEFEE IPSEAATIAS AWAGGTDGMD VTSTLLNQLK DILSQDGVFY 180
  181 MVAVARNKLH SICEILQKDG FIVNETLKRK AGRETLSILR IYRIGNTIWD E

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	36.30103
Match:	1t43A
Description:	Crystal Structure Analysis of E.coli Protein (N5)-Glutamine Methyltransferase (HemK)
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
protein methyltransferase activity	5.03267617653315	bayes_pls_golite062009
S-adenosylmethionine-dependent methyltransferase activity	4.4632173842967	bayes_pls_golite062009
methyltransferase activity	4.15445027778357	bayes_pls_golite062009
N-methyltransferase activity	4.07806017452628	bayes_pls_golite062009
transferase activity, transferring one-carbon groups	4.07153733729662	bayes_pls_golite062009
histone methyltransferase activity	3.97658336148086	bayes_pls_golite062009
protein-arginine N-methyltransferase activity	3.26663548517117	bayes_pls_golite062009
arginine N-methyltransferase activity	3.26663548517117	bayes_pls_golite062009
transferase activity	2.926540904444	bayes_pls_golite062009
histone-arginine N-methyltransferase activity	2.86617323549909	bayes_pls_golite062009
protein-arginine omega-N monomethyltransferase activity	2.48017990451667	bayes_pls_golite062009
DNA-methyltransferase activity	2.18991764495147	bayes_pls_golite062009
histone methyltransferase activity (H4-R3 specific)	1.91133457052099	bayes_pls_golite062009
protein-arginine omega-N asymmetric methyltransferase activity	1.69391860928068	bayes_pls_golite062009
transcription regulator activity	1.61435611638306	bayes_pls_golite062009
DNA binding	1.53375495589674	bayes_pls_golite062009
nucleic acid binding	1.31440474302645	bayes_pls_golite062009
catalytic activity	1.25333584501255	bayes_pls_golite062009
protein-arginine omega-N symmetric methyltransferase activity	1.15089820497406	bayes_pls_golite062009
binding	0.976078016260105	bayes_pls_golite062009
protein binding	0.871386560666009	bayes_pls_golite062009
RNA methyltransferase activity	0.817509452491588	bayes_pls_golite062009
site-specific DNA-methyltransferase (adenine-specific) activity	0.703178429468566	bayes_pls_golite062009
lysine N-methyltransferase activity	0.469870476227704	bayes_pls_golite062009
protein-lysine N-methyltransferase activity	0.469870476227704	bayes_pls_golite062009
histone-lysine N-methyltransferase activity	0.469870476227704	bayes_pls_golite062009
rRNA methyltransferase activity	0.230719796976667	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: