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View Structure Prediction Details

Protein: nup132
Organism: Schizosaccharomyces pombe
Length: 1162 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for nup132.

Description E-value Query
Range
Subject
Range
gi|32405426, gi|... - gi|32405426|ref|XP_323326.1| hypothetical protein [Neurospora crassa], gi|28918716|gb|EAA28386.1| pr...
gi|85086089 - gi|85086089|ref|XP_957622.1| hypothetical protein NCU04007 [Neurospora crassa OR74A]
1087.0 [0..17] [1160..85]
gi|38111563, gi|... - gi|39945944|ref|XP_362509.1| hypothetical protein MG08092.4 [Magnaporthe grisea 70-15], gb|EAA57123....
1077.0 [0..18] [1159..79]
gi|29150121 - gi|29150121|emb|CAD79681.1| conserved hypothetical protein [Neurospora crassa]
1072.0 [0..17] [1160..85]
gi|42544415, gi|... - gi|46136899|ref|XP_390141.1| hypothetical protein FG09965.1 [Gibberella zeae PH-1], gi|42544415|gb|E...
1023.0 [0..33] [1158..108]
NUP133 - nucleoporin 133kDa
gi|157928803, gi... - gi|157928803|gb|ABW03687.1| nucleoporin 133kDa [synthetic construct], gi|123995185|gb|ABM85194.1| nu...
913.0 [0..5] [1101..39]
gi|34851885, gi|... - ref|XP_214721.2| similar to RIKEN cDNA 4832420O05 [Rattus norvegicus], gi|109509038|ref|XP_001053507...
911.0 [0..5] [1101..38]
gi|26325276 - gi|26325276|dbj|BAC26392.1| unnamed protein product [Mus musculus]
909.0 [0..5] [1101..38]

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Predicted Domain #1
Region A:
Residues: [1-455]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSSILGKRKN EEVVSFSPLK RISVEKSLLD STAYNNSLDW LRSKNFKVSC LLKHFNSKII  60
   61 NDHPLSGSCY TDIGYALINS RKACFILSYR QSLGTAEPPT ITFPLPEEDS NGFSGQNALT 120
  121 AFVPSDASDK EPGLLIVMPI SGRIAYWTSI GNALAQSYIC PQGMESLIKL LPKEKCEHLC 180
  181 CSNPMKFIIS TNFGRLFSVQ LRDPAGQPDV SVQLFASDIS TFSTILQKMK IFNYPSIHII 240
  241 ALKSPPLFSP YQHLLYVAEA SGLLEIYDLK LENKLVSGMN LSPIFKQVLR EGCPDASGLE 300
  301 VLDLTICPTN GNLVSFLVCW KNSINYRYMI ISLDFSDISS PSVMNIHPLY SFSSKSLESS 360
  361 KLHYSSSGNS LFVVLTDAVI IVHVQEDDKD IVSRTSWEEV IRMNTNVSGG IFMSTCYKYV 420
  421 LGKYSIPTES CFIATPYSGI AEIEVHSLEH PANNE

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 97.0
Match: 1xksA
Description: The crystal structure of the N-terminal domain of Nup133 reveals a beta-propeller fold common to several nucleoporins
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
nucleocytoplasmic transporter activity 7.36869426424539 bayes_pls_golite062009
transporter activity 2.55928656852707 bayes_pls_golite062009
binding 2.00508289492248 bayes_pls_golite062009
protein binding 0.548945337973353 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [456-555]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SLVKSKLEEA VFYSFLPGNP IDFSCNYLRS IKKPELERII VDLGMDILNS RSTHLPPLFA  60
   61 SLMQHLSCRL NSLNNLVRYI RSMSLDVDRQ VLYKLRVMGE 

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [556-622]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KCNSVRYLWN TIDTEFSTVS HSLIFQRIIY RLTQSASSDN ALREWFLHNI ESIDQLIAQA  60
   61 HEFCIDS

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #4
Region A:
Residues: [623-825]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GSRVQELPLE VLDVIMEANE VILAIQSSAL AYRRESQKIY KLSIDTFGEE VPWTSTPETL  60
   61 VLLCRQFELT RSALVQSHQG TSDVENTFKI KDKGVLRNVV SNLEVQLVAL TEVCFDAYSE 120
  121 RIRWIEQRCG KDASEIQDVK EAFAVNRRFW VQTLSDIGKG SSAIRIAEKY SDYRSLVELC 180
  181 YQLYEDNELT DALNNYLDLF GIK

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #5
Region A:
Residues: [826-1003]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 FAFILYDYFV ENGMALELLN SDRFNKSYLK QFFKSRDYNQ ISWMHDMRLG DYDAASHRLL  60
   61 QLATKQEKLV DKKESELSLS KLFLYAVPSN SGNIRDLVLV EQKLEQLHIQ KMVSKSVMPV 120
  121 VERLRSQGKK YQLVEAVVDD LIGAKVAPVI ARQVMQRVVK KFIAGQVVEA TELLEYLS

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #6
Region A:
Residues: [1004-1162]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 FSLYRREDLV EGEVTDYYLA LRLLLTTRLT DDAKRFYENT IWRRAVLHDN WIQVLDTQGK  60
   61 NDAIIETQFR MSALYRTLEA VTINGLFHEG LIRPGSLSSC KFEGYDPQNL ISIYPPARFG 120
  121 DVTEVTKVLN RESVKLDHYL TKTNLNTCYI SMCLSCDTI

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle