YRC Public Data Repository - Protein Structure Prediction

Protein:	jmj4
Organism:	Schizosaccharomyces pombe
Length:	473 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for jmj4.

Description	E-value	Query Range	Subject Range
JMJ30_ARATH - Putative lysine-specific demethylase JMJD5 OS=Arabidopsis thaliana GN=JMJD5 PE=2 SV=1	210.0	[0..12]	[273..179]
gi\|10435927, gi\|... - gi\|13376123\|ref\|NP_079049.1\| jumonji domain containing 5 [Homo sapiens], gi\|10435927\|dbj\|BAB14706.1\|...	207.0	[0..21]	[273..184]
gi\|114661702, gi... - gi\|114661702\|ref\|XP_001135546.1\| PREDICTED: jumonji domain containing 5 isoform 2 [Pan troglodytes],...	204.0	[0..21]	[273..184]
KDM8_BOVIN - Lysine-specific demethylase 8 OS=Bos taurus GN=KDM8 PE=2 SV=1	204.0	[0..13]	[273..164]
gi\|109127990 - gi\|109127990\|ref\|XP_001100489.1\| PREDICTED: similar to CG13902-PA [Macaca mulatta]	204.0	[0..11]	[273..174]
gi\|73958640 - gi\|73958640\|ref\|XP_850038.1\| PREDICTED: similar to CG13902-PA [Canis familiaris]	200.0	[0..13]	[273..172]
KDM8_RAT - Lysine-specific demethylase 8 OS=Rattus norvegicus GN=Kdm8 PE=2 SV=1	200.0	[0..13]	[273..172]
KDM8_MOUSE - Lysine-specific demethylase 8 OS=Mus musculus GN=Kdm8 PE=2 SV=1	199.0	[0..13]	[273..172]

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Predicted Domain #1

Region A:
Residues: [1-286]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSELSTYKGY SPKHGDKVPV LQNLNDLTPK DFYDKFIATR TPVIIKSSLP ESDWKGYLWQ  60
   61 QQDYLLSKIG DIVCKVEPID PVSGTFGQGM SRNEMSIKEF FQKLKNGERL YLTTQYDESN 120
  121 EVLDGDDEVS LLVKSLCPHP TDGLLTDFSI TPALMGNLVP QQCNLWIGKS ENGTSSGLHH 180
  181 DFHDNIYAVI SGYKRFVIIS PDHANQLKLS GKISKIHPNG LISYEGEDCP QRSDGLTELD 240
  241 AAIAKTQFLE KKIGSLKELA VPQESIELLE AEYENEMDRV LQMQIG

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	46.0
Match:	1mzeA
Description:	Hypoxia-inducible factor HIF ihhibitor (FIH1)
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
demethylase activity	3.52239441642457	bayes_pls_golite062009
DNA binding	2.56912448296176	bayes_pls_golite062009
nucleic acid binding	2.2622484386078	bayes_pls_golite062009
binding	1.98106807488954	bayes_pls_golite062009
damaged DNA binding	1.1610242625285	bayes_pls_golite062009
catalytic activity	0.921320409505	bayes_pls_golite062009
protein binding	0.300532513511442	bayes_pls_golite062009
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors	0.197876250194678	bayes_pls_golite062009

Predicted Domain #2

Region A:
Residues: [287-473]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GPEEDWNDLE EGDAASLLDG SVGGDPESDI LLNEGNDIEA TSLQDTKPEL PDHFTKVSVN  60
   61 GLHKFMGFDD AKNVDVDKDE LSALAGTVPL VVDLEPGDML YLPASWFHEV TSSSASSGGS 120
  121 DVHIAFNYWF HPPDNLEDFD HPYLDRNIWQ AKRHLVGEAI DQLYATNKKN EKRPAEDDSP 180
  181 SQKKTCQ

[Run NCBI BLAST on this sequence.]

Detection Method:	FFAS03
Confidence:	5.02
Match:	1mzeA
Description:	Hypoxia-inducible factor HIF ihhibitor (FIH1)
Matching Structure (courtesy of the PDB):

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: