YRC Public Data Repository - Protein Structure Prediction

Protein:	SPCC1450.10c
Organism:	Schizosaccharomyces pombe
Length:	538 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for SPCC1450.10c.

Description	E-value	Query Range	Subject Range
gi\|125972863, gi... - gi\|67916533\|ref\|ZP_00510240.1\| Ferredoxin:4Fe-4S ferredoxin, iron-sulfur binding domain:Iron hydroge...	487.0	[0..1]	[525..129]
gi\|20807375, gi\|... - gi\|20807375\|ref\|NP_622546.1\| NADH dehydrogenase/NADH:ubiquinone oxidoreductase 75 kD subunit (chain ... gi\|20807375 - gi\|20807375\|ref\|NP_622546.1\| NADH dehydrogenase/NADH:ubiquinone oxidoreductase 75 kD subunit (chain ...	484.0	[0..3]	[525..131]
gi\|4927278 - gi\|4927278\|gb\|AAD33071.1\| hydrogenase-1 [Clostridium thermocellum]	484.0	[0..1]	[525..127]
gi\|167037864, gi... - gi\|76795773\|ref\|ZP_00778144.1\| Ferredoxin:4Fe-4S ferredoxin, iron-sulfur binding:Iron hydrogenase, s... gi\|241884287, gi... - gi\|241903376\|ref\|ZP_04788101.1\| hydrogenase, Fe-only [Thermoanaerobacter brockii subsp. finnii Ako-1...	476.0	[0..3]	[525..131]
gi\|85858940, gi\|... - gi\|85858940\|ref\|YP_461142.1\| iron only hydrogenase large subunit [Syntrophus aciditrophicus SB], gi\|...	471.0	[0..6]	[524..141]
gi\|7433127 - pir\|\|C72405 hydrogenase (EC 1.18.99.1) (Fe) large chain [similarity] - Thermotoga maritima (strain M... gi\|15642974, gi\|... - gi\|4980698\|gb\|AAD35293.1\|AE001705_4 NADP-reducing hydrogenase, subunit D, putative [Thermotoga marit...	469.0	[0..6]	[526..160]
gi\|82402638, gi\|... - gi\|82499410\|ref\|ZP_00884856.1\| NADH dehydrogenase/NADH:ubiquinone oxidoreductase 75 kD subunit (chai...	467.0	[0..5]	[524..133]
gi\|89897458, gi\|... - gi\|89897458\|ref\|YP_520945.1\| putative hydrogenase large subunit [Desulfitobacterium hafniense Y51], ...	461.0	[0..4]	[533..97]
gi\|109641296, gi... - gi\|68206249\|ref\|ZP_00558440.1\| Twin-arginine translocation pathway signal [Desulfitobacterium hafnie...	461.0	[0..4]	[533..69]
gi\|158140165, gi... - gi\|158319966\|ref\|YP_001512473.1\| hydrogenase, Fe-only [Alkaliphilus oremlandii OhILAs], gi\|158140165...	460.0	[0..7]	[526..131]

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Predicted Domain #1

Region A:
Residues: [1-538]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAKLSVNDLN DFLSPGAVCI KPAQVKKQES KNDIRIDGDA YYEVTKDTGE TSELGIASIS  60
   61 LNDCLACSGC ITSAETVLVN LQSYQEVLKH LESRKSQEIL YVSLSPQVRA NLAAYYGLSL 120
  121 QEIQAVLEMV FIGKLGFHAI LDTNASREIV LQQCAQEFCN SWLQSRAHKN QNQVTNSVVN 180
  181 EHPLIPHSTS QISGVHSNTS SNSGINENAV LPILSSSCPG WICYVEKTHS NLIPNLSRVR 240
  241 SPQQACGRIL KDWAVQQFSM QRNDVWHLSL MPCFDKKLEA SRDEFSENGV RDVDSVLTPK 300
  301 ELVEMFKFLR IDPIELTKNP IPFQQSTDAI PFWYPRITYE EQIGSSSGGY MGYVLSYAAK 360
  361 MLFGIDDVGP YVSMNNKNGD LTEYTLRHPE TNEQLISMAT CYGFRNIQNL VRRVHGNSSV 420
  421 RKGRVLLKKR VRSNAQNPTE EPSRYDYVEV MACPGGCING GGQLPFPSVE RIVSARDWMQ 480
  481 QVEKLYYEPG TRSVDQSAVS YMLEQWVKDP TLTPKFLHTS YRAVQTDNDN PLLLANKW

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	118.0
Match:	1c4aA
Description:	Fe-only hydrogenase, catalytic domain; Fe-only hydrogenase, N-terminal domain; Fe-only hydrogenase, second domain
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
binding	1.47874003627413	bayes_pls_golite062009
NADH dehydrogenase (ubiquinone) activity	1.31458462821219	bayes_pls_golite062009
iron-sulfur cluster binding	1.18054918348653	bayes_pls_golite062009
metal cluster binding	1.18054918348653	bayes_pls_golite062009
NADH dehydrogenase activity	1.10428419414285	bayes_pls_golite062009
lamin binding	0.863386378061341	bayes_pls_golite062009
NADH dehydrogenase (quinone) activity	0.778342926116907	bayes_pls_golite062009
catalytic activity	0.488483980994331	bayes_pls_golite062009
oxidoreductase activity, acting on NADH or NADPH, quinone or similar compound as acceptor	0.312816353615077	bayes_pls_golite062009
ferredoxin hydrogenase activity	0.278768281741128	bayes_pls_golite062009
oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor	0.278768281741128	bayes_pls_golite062009
protein binding	0.221871950373022	bayes_pls_golite062009
electron carrier activity	0.0554226204149908	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: