YRC Public Data Repository - Protein Structure Prediction

Protein:	trm12
Organism:	Schizosaccharomyces pombe
Length:	418 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for trm12.

Description	E-value	Query Range	Subject Range
Y1863_LISIN - Uncharacterized RNA methyltransferase lin1863 OS=Listeria innocua serovar 6a (strain CLIP 11262) GN=... Y1863_LISIN, YI6... - (Q92AQ7) Hypothetical RNA methyltransferase lin1863 (EC 2.1.1.-), Uncharacterized RNA methyltransfer...	198.0	[0..8]	[361..87]
gi\|47095677, gi\|... - gi\|47095677\|ref\|ZP_00233284.1\| RNA methyltransferase, TrmA family [Listeria monocytogenes str. 1/2a ... gi\|255028262 - gi\|255028262\|ref\|ZP_05300213.1\| hypothetical protein LmonL_01654 [Listeria monocytogenes LO28] YH51_LISMO, Y175... - (Q8Y6D6) Hypothetical RNA methyltransferase lmo1751 (EC 2.1.1.-), Uncharacterized RNA methyltransfer... gi\|126941860, gi... - gi\|254900744\|ref\|ZP_05260668.1\| hypothetical protein LmonJ_13049 [Listeria monocytogenes J0161], gi\|... gi\|224503324 - gi\|224503324\|ref\|ZP_03671631.1\| hypothetical protein LmonFR_12550 [Listeria monocytogenes FSL R2-561... Y1751_LISMO - Uncharacterized RNA methyltransferase lmo1751 OS=Listeria monocytogenes serovar 1/2a (strain ATCC BA... gi\|127765381, gi... - gi\|254913771\|ref\|ZP_05263783.1\| hypothetical protein LmonJ2_13279 [Listeria monocytogenes J2818], gi... gi\|133732615, gi... - gi\|254938158\|ref\|ZP_05269855.1\| hypothetical protein LmonF6_13559 [Listeria monocytogenes F6900], gi...	198.0	[0..8]	[361..87]
gi\|226224354, gi... - gi\|226224354\|ref\|YP_002758461.1\| hypothetical RNA methyltransferase [Listeria monocytogenes Clip8145... gi\|254992256 - gi\|254992256\|ref\|ZP_05274446.1\| hypothetical RNA methyltransferase [Listeria monocytogenes FSL J2-06... Y1776_LISMF - Uncharacterized RNA methyltransferase LMOf2365_1776 OS=Listeria monocytogenes serotype 4b (strain F2...	196.0	[0..8]	[361..87]
gi\|47092904, gi\|... - gi\|47092904\|ref\|ZP_00230686.1\| RNA methyltransferase, TrmA family [Listeria monocytogenes str. 4b H7... gi\|255521018 - gi\|255521018\|ref\|ZP_05388255.1\| hypothetical RNA methyltransferase [Listeria monocytogenes FSL J1-17...	195.0	[0..8]	[361..87]
Y687_BACHD - Uncharacterized RNA methyltransferase BH0687 OS=Bacillus halodurans GN=BH0687 PE=3 SV=1 Y687_BACHD - Uncharacterized RNA methyltransferase BH0687 OS=Bacillus halodurans (strain ATCC BAA-125 / DSM 18197...	193.0	[0..7]	[361..88]
gi\|52784541, gi\|... - gi\|52784541\|ref\|YP_090370.1\| YefA [Bacillus licheniformis ATCC 14580], gi\|52347043\|gb\|AAU39677.1\| Ye...	190.0	[0..7]	[361..87]
Y2481_CLOTE - Uncharacterized RNA methyltransferase CTC_02481 OS=Clostridium tetani (strain Massachusetts / E88) G... Y2481_CLOTE, YO8... - (Q891A0) Hypothetical RNA methyltransferase CTC02481 (EC 2.1.1.-), Uncharacterized RNA methyltransfe...	189.0	[0..7]	[355..87]
gi\|46113357, gi\|... - gi\|68054113\|ref\|ZP_00538277.1\| 23S rRNA methyltransferase/RumA [Exiguobacterium sibiricum 255-15], g...	188.0	[0..7]	[383..84]
YEFA_BACSU, RLMC... - Uncharacterized RNA methyltransferase yefA OS=Bacillus subtilis GN=yefA PE=3 SV=1, 23S rRNA (uracil-... gi\|221312833 - gi\|221312833\|ref\|ZP_03594638.1\| hypothetical protein BsubsN3_03754 [Bacillus subtilis subsp. subtili... RLMCD_BACSU - 23S rRNA (uracil-C(5))-methyltransferase RlmCD OS=Bacillus subtilis (strain 168) GN=rlmCD PE=1 SV=1 gi\|221317757 - gi\|221317757\|ref\|ZP_03599051.1\| hypothetical protein BsubsJ_03708 [Bacillus subtilis subsp. subtilis... gi\|221322036 - gi\|221322036\|ref\|ZP_03603330.1\| hypothetical protein BsubsS_03794 [Bacillus subtilis subsp. subtilis...	188.0	[0..7]	[361..87]
gi\|56378719, gi\|... - gi\|56418877\|ref\|YP_146195.1\| RNA methyltransferase [Geobacillus kaustophilus HTA426], gi\|56378719\|db...	186.0	[0..7]	[385..88]

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Predicted Domain #1

Region A:
Residues: [1-418]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MISFLVQKSE AKYWKDVVQN KNKFLKNIGI ISGPKLVDTY SNQFEADFLK KCVLIPTSYN  60
   61 KEDLPKDILD CPRIYLIEEE VKSVQTDEKL QIKVLRYVSQ ILHTTVSEEQ YPVPSRFVIY 120
  121 PPLALLSLNS FGTKEWHLFF QSYANVDVKA GLFDIFAREW NVSHIAINEP IPVGDVMRRP 180
  181 LSLKPLYGDF GVLIDGNPSE QDFQKAFWVS CRQNGIYQTW APLYTMFSRG NSIEKARVLN 240
  241 FSYIKDEIIA DLYAGIGYFT FSYVKAGAST VFCWEINPWS VEALRRAALK NGWSIYVVRN 300
  301 GENYEFKVGT HRIVVFLESN VYAAERFSKM NISARHINLG MLPSSEKSWS TATSILKRES 360
  361 HSFIHVHENV KDEDIETYSS EVNSCFSKML AKNTVCVTNC VKSFSPRVSH IVYDIETV

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	29.0
Match:	1sqfA
Description:	The crystal structure of E. coli Fmu binary complex with S-Adenosylmethionine at 2.1 A resolution
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
methyltransferase activity	4.15445027778357	bayes_pls_golite062009
N-methyltransferase activity	4.07806017452628	bayes_pls_golite062009
transferase activity, transferring one-carbon groups	4.07153733729662	bayes_pls_golite062009
protein methyltransferase activity	3.92746815303714	bayes_pls_golite062009
S-adenosylmethionine-dependent methyltransferase activity	3.39429041855776	bayes_pls_golite062009
RNA methyltransferase activity	3.07428840534971	bayes_pls_golite062009
histone methyltransferase activity	2.99461585647365	bayes_pls_golite062009
transferase activity	2.926540904444	bayes_pls_golite062009
tRNA methyltransferase activity	2.5931020126592	bayes_pls_golite062009
arginine N-methyltransferase activity	2.41876112831625	bayes_pls_golite062009
protein-arginine N-methyltransferase activity	2.41876112831625	bayes_pls_golite062009
rRNA methyltransferase activity	2.29640050660273	bayes_pls_golite062009
DNA-methyltransferase activity	2.18991764495147	bayes_pls_golite062009
histone-arginine N-methyltransferase activity	2.04296107639729	bayes_pls_golite062009
tRNA (cytosine-5-)-methyltransferase activity	1.88889414729709	bayes_pls_golite062009
tRNA (cytosine)-methyltransferase activity	1.88889414729709	bayes_pls_golite062009
protein-arginine omega-N monomethyltransferase activity	1.66871163498737	bayes_pls_golite062009
transcription termination factor activity	1.58162486937564	bayes_pls_golite062009
tRNA (adenine-N1-)-methyltransferase activity	1.29759910099835	bayes_pls_golite062009
tRNA (adenine)-methyltransferase activity	1.29759910099835	bayes_pls_golite062009
catalytic activity	1.25333584501255	bayes_pls_golite062009
histone methyltransferase activity (H4-R3 specific)	1.1103522853299	bayes_pls_golite062009
transcription regulator activity	0.914549843668268	bayes_pls_golite062009
protein-arginine omega-N asymmetric methyltransferase activity	0.89325812193225	bayes_pls_golite062009
DNA binding	0.86027591375666	bayes_pls_golite062009
site-specific DNA-methyltransferase (adenine-specific) activity	0.703178429468566	bayes_pls_golite062009
nucleic acid binding	0.616949327277483	bayes_pls_golite062009
rRNA (adenine) methyltransferase activity	0.533090627724779	bayes_pls_golite062009
rRNA (adenine-N6,N6-)-dimethyltransferase activity	0.455449410561251	bayes_pls_golite062009
RNA binding	0.417524996559564	bayes_pls_golite062009
binding	0.383237930789959	bayes_pls_golite062009
protein-arginine omega-N symmetric methyltransferase activity	0.364369105571521	bayes_pls_golite062009
tRNA (guanine) methyltransferase activity	0.203168546434167	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: