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View Structure Prediction Details

Protein: ste6
Organism: Schizosaccharomyces pombe
Length: 911 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for ste6.

Description E-value Query
Range
Subject
Range
gi|114577094 - gi|114577094|ref|XP_515425.2| PREDICTED: son of sevenless homolog 1 [Pan troglodytes]
496.0 [0..260] [905..638]
gi|109478930 - gi|109478930|ref|XP_001062567.1| PREDICTED: similar to Son of sevenless homolog 1 [Rattus norvegicus...
494.0 [0..287] [905..579]
gi|74148823 - gi|74148823|dbj|BAE24327.1| unnamed protein product [Mus musculus]
491.0 [0..287] [905..394]
gi|56554478, gi|... - gi|56554478|pdb|1XD4|B Chain B, Crystal Structure Of The Dh-Ph-Cat Module Of Son Of Sevenless (Sos),...
490.0 [0..260] [905..176]

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Predicted Domain #1
Region A:
Residues: [1-106]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MRFQTTAISD YENSSNPSFL KFSAGDTIIV IEVLEDGWCD GICSEKRGWF PTSCIDSSKI  60
   61 QNFFSSFHSS NEKDPNAQCC APFHVEAHLQ DSAWFEKHGV QAINSI

[Run NCBI BLAST on this sequence.]

Detection Method: FFAS03
Confidence: 4.51
Match: 1uffA
Description: Solution structure of the first SH3 domain of human intersectin2 (KIAA1256)
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
binding 2.01939163574954 bayes_pls_golite062009
protein binding 1.71199213513011 bayes_pls_golite062009
cytoskeletal protein binding 0.169020668544027 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [107-258]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PSSEEFLRKN LQNDIHHLVK GILTTAAAVS QSIKKEGTQV IVFGIETVRS MVLSFPLIIL  60
   61 STLDENFLSE VAQVFSSLNL LPELSRMGCT YGELCIRFTK LLKQLANKFL FFFRPDVSFP 120
  121 SYFLGSLIAH EIHFLPWDFN MLCSNSVQSA HT

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [259-911]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NLQPDITSFV AILSLSHEAY HCTENEFWNL EAQKLTENTT QKVLQLVAED ALEAWKLDIL  60
   61 EDIDRCIQCC RRFLSANQRI NYSSSENNPF SFTSQDVEAL KDELSSNLCD LYLWSIDLEQ 120
  121 ISPSDCLLDN YSLFVDLLVT LKVSLLRIKS IIVQFSERIV FLSLEYKFLT NIQPELNDAE 180
  181 KSQLDGFDLN KTNWFDSKGL VCYLMKQTSP EPLLIRNLLF SFWSCNGKIE QDGKIKTATL 240
  241 VFIINYLLRT DIDSTFFTTI FLNTYASMIS SSDLFSILGA HFRFICSLNF GKISFISHEF 300
  301 YRVSKRFLDI LLIWFESYLV EELDNSKSIF FLFKIYKVFE VFVVPHFASA EELLHSLSHL 360
  361 LHHPSTKRSH KMLEGKELSQ ELEDLSLHNS PDPIIYKDEL VLLLPPREIA KQLCILEFQS 420
  421 FSHISRIQFL TKIWDNLNRF SPKEKTSTFY LSNHLVNFVT ETIVQEEEPR RRTNVLAYFI 480
  481 QVCDYLRELN NFASLFSIIS ALNSSPIHRL RKTWANLNSK TLASFELLNN LTEARKNFSN 540
  541 YRDCLENCVL PCVPFLGVYF TDLTFLKTGN KDNFQNMINF DKRTKVTRIL NEIKKFQSVG 600
  601 YMFNPINEVQ ELLNEVISRE RNTNNIYQRS LTVEPRESED QALQRLLIDS GIF

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 139.0
Match: 1xd4A
Description: Crystal structure of the DH-PH-cat module of Son of Sevenless (SOS)
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
binding 2.34731558780557 bayes_pls_golite062009
protein binding 1.90786769159903 bayes_pls_golite062009
Rho guanyl-nucleotide exchange factor activity 0.885131503553978 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle