YRC Public Data Repository - Protein Structure Prediction

Protein:	pim1
Organism:	Schizosaccharomyces pombe
Length:	539 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for pim1.

Description	E-value	Query Range	Subject Range
gi\|67190866 - gi\|67190866\|ref\|NP_004658.2\| hect domain and RLD 2 [Homo sapiens]	357.0	[0..9]	[417..2954]
gi\|50730386 - gi\|50730386\|ref\|XP_416878.1\| PREDICTED: similar to hect domain and RLD 2 [Gallus gallus]	356.0	[0..9]	[417..3290]
gi\|73952408 - gi\|73952408\|ref\|XP_536160.2\| PREDICTED: similar to hect domain and RLD 2 isoform 1 [Canis familiaris...	355.0	[0..9]	[417..2955]
gi\|109080433 - gi\|109080433\|ref\|XP_001109429.1\| PREDICTED: similar to hect domain and RLD 2 [Macaca mulatta]	355.0	[0..9]	[417..2954]
gi\|3414809 - gi\|3414809\|gb\|AAC31431.1\| rjs [Mus musculus]	354.0	[0..11]	[417..2957]
gi\|76662857 - gi\|76662857\|ref\|XP_615528.2\| PREDICTED: similar to hect domain and RLD 2 isoform 1 [Bos taurus]	354.0	[0..9]	[417..2960]
gi\|109462038 - gi\|109462038\|ref\|XP_001054649.1\| PREDICTED: similar to hect (homologous to the E6-AP (UBE3A) carboxy...	354.0	[0..11]	[417..2957]
gi\|47214126 - gi\|47214126\|emb\|CAG01384.1\| unnamed protein product [Tetraodon nigroviridis]	351.0	[0..9]	[417..2725]

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Predicted Domain #1

Region A:
Residues: [1-539]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTSNRSTRSS TKREEVSKNG VEKRELDESD VMKNGKKPVK RAKVSSLPKP VRVPGSAKRI  60
   61 NKIPELPTER LNVYVFGSGS MNELGMGEEE MDVVYRPRLN PILSTDKVGV VDLAVGGMHS 120
  121 AALSHDGRVY TWGVNDDYAL GRLTKDQKDE NGDKVDNDLL EGTPSKVEGA LSHLRVTKVI 180
  181 CSDNLTAAIT DNGCCFTWGT FRCSDGVLGY SDSQKRTAEP TQMRLPEICQ LATGTDHIIA 240
  241 LTTTGKVYTW GNGQQFQLGR RMLERRRLQG LTPQPLALKN IISVGAGSYH SFAIDNKGRV 300
  301 YAWGLNITRQ CGIEVEDEEE GAVITKPTLV DALEGYNVKS ITGGEHHTLA LLEDGRVLAW 360
  361 GRDDRHQLGI PDNALPETVV KDEKGNNYYL STPTIIPGLT NVIQVVCGTH HNLAVTSDGK 420
  421 VYSWGSAENY EVGQGDNDED VAVPTLVRSK AIKEVAIRVA GAGGQFSIIA GIPNASEEPV 480
  481 ANGIKSEPEN EKKLKTEETS KTDDSPVTDA KPDVTSNGEP STATSESKDS VLEPSSTTA

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	76.0
Match:	1a12A
Description:	Regulator of chromosome condensation RCC1
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
GTPase regulator activity	2.91135341067617	bayes_pls_golite062009
nucleoside-triphosphatase regulator activity	2.89051221007497	bayes_pls_golite062009
small GTPase regulator activity	2.78763396258796	bayes_pls_golite062009
guanyl-nucleotide exchange factor activity	2.67769296699335	bayes_pls_golite062009
Ras guanyl-nucleotide exchange factor activity	2.54000969805561	bayes_pls_golite062009
enzyme regulator activity	2.16356879283979	bayes_pls_golite062009
Ran guanyl-nucleotide exchange factor activity	1.99390987036621	bayes_pls_golite062009
binding	1.94765972306941	bayes_pls_golite062009
chromatin binding	1.1028187707197	bayes_pls_golite062009
histone binding	0.76536700536926	bayes_pls_golite062009
protein binding	0.568399753749593	bayes_pls_golite062009
catalytic activity	0.261970921089142	bayes_pls_golite062009
ligase activity	0.233377687886995	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: