YRC Public Data Repository - Protein Structure Prediction

Protein:	plc1
Organism:	Schizosaccharomyces pombe
Length:	899 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for plc1.

Description	E-value	Query Range	Subject Range
gi\|619519, gi\|10... - gi\|619519\|emb\|CAA58591.1\| putative phosphoinositide specific phospholipase C [Schizosaccharomyces po...	791.0	[0..1]	[899..1]
gi\|114586177 - gi\|114586177\|ref\|XP_526146.2\| PREDICTED: phospholipase C-like 2 [Pan troglodytes]	710.0	[0..44]	[898..235]
gi\|5689521 - gi\|5689521\|dbj\|BAA83044.1\| KIAA1092 protein [Homo sapiens]	704.0	[0..44]	[898..73]
gi\|74178467 - gi\|74178467\|dbj\|BAE32490.1\| unnamed protein product [Mus musculus]	686.0	[0..47]	[898..50]
gi\|109486503 - gi\|109486503\|ref\|XP_001056257.1\| PREDICTED: similar to phospholipase C-like 2 [Rattus norvegicus]	686.0	[0..47]	[898..40]
gi\|73990022 - gi\|73990022\|ref\|XP_542772.2\| PREDICTED: similar to phospholipase C-like 2 isoform 1 [Canis familiari...	673.0	[0..48]	[898..54]
gi\|42820731 - gi\|42820731\|emb\|CAF32044.1\| 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase 1, putative [A... gi\|159131450 - gi\|159131450\|gb\|EDP56563.1\| 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase 1, putative [A... gi\|70995880, gi\|... - gi\|70995880\|ref\|XP_752695.1\| 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase Plc1, putativ...	669.0	[0..8]	[898..97]

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Predicted Domain #1

Region A:
Residues: [1-105]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MNCEMVTSPE SVNLGDSNRA VSPFCLPDCS ENAVAQTRSK TLDNAALDLP YVGNRKKSEQ  60
   61 DFFKMLSSRD RDAHSTLRKR SNSLSSFLST KSTSASENKF HGGLN

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

		MCM Score	SCOP Match	SCOP Description
View	Download	0.316	a.118.11	Cytochrome c oxidase subunit E
View	Download	0.267	a.26.1	4-helical cytokines
View	Download	0.236	c.55.7	Methylated DNA-protein cysteine methyltransferase domain
View	Download	0.232	a.118.26	Description not found.
View	Download	0.230	c.55.7	Methylated DNA-protein cysteine methyltransferase domain
View	Download	0.222	c.47.1	Thioredoxin-like
View	Download	0.211	a.118.11	Cytochrome c oxidase subunit E

Predicted Domain #2

Region A:
Residues: [106-287]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 WLSLKLNLLL RLQGRMNSAR TNTSMNPYSC DSNENLSTLS SVNQNFNSRQ LLATIVPESI  60
   61 QNGCSLLRIT KKKVRQRKVS LDPISGYLML DKNTGKAYKK LCVDDIKEIR QGRDARNYRE 120
  121 QYKISSENEK RWFTIIYCAD NKLKAMHMIS PTLDAHNQWI MALEGLKTYR LNEFIIGLNL 180
  181 VC

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	25.0
Match:	1sjjA
Description:	Cryo-EM Structure of Chicken Gizzard Smooth Muscle alpha-Actinin
Matching Structure (courtesy of the PDB):

Predicted Domain #3

Region A:
Residues: [288-899]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 HQGEKMIDYS ENLNPWEKLE KEQSAQLDLG DVHRMCQMLH LNASMEFLEE TFQKADADHS  60
   61 GKLSFEEFQH FVSLLKTRSE IVDIFKEYTS GSDKMSLEQF RHFLSTSQKA RLDSDSIRTL 120
  121 YVSFCSNDDS KMGLIEFTSF LLSPHNSPVV PVIQDMSRPL NEYLISSSHN TYLLGKQFGG 180
  181 ESSIEGYIRS LQRGCKCIEI DCWDGPNGPV VCHGHTFTSM IKFNDVIDAI RKYAFVVSPY 240
  241 PLFISLEIHC CPDQQRQMVS YMKQAFGDTL VMKPVTANES VLPSPEDLLN KILLKVKCSA 300
  301 TPLHQFSTDI LKVGITDSST DTTESSELEN SELTGLRKGK RRMKNIIVQE LQQLAPYARS 360
  361 LKFRNFSLPE SKTYSHIFSF SERTIKKHGK AMVPRLSKHN LRYLCRVYPG PLRVGSTNFN 420
  421 PQVYWRLGVQ MVALNWQTYD TGLQINDALF IADPPTGYLL KPPCQRIIGT TVGEEGLPRK 480
  481 IKLTIDVISG QQLRRARELS NSETLSPYVE IQVHSMEESP FRWCSKVVHE NGFRPFWGET 540
  541 MVYESIISDD FYSMIRFLVH HRGSNGNDSI FANFTCPIDR LQQGYRHIRL LDMQGENLLF 600
  601 SSLFLKIKKE DI

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	167.0
Match:	1djgA
Description:	Phosphoinositide-specific phospholipase C, isozyme D1 (PLC-D!); PI-specific phospholipase C isozyme D1 (PLC-D1), C-terminal domain; Phospholipase C isozyme D1 (PLC-D1)
Matching Structure (courtesy of the PDB):

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits