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View Structure Prediction Details

Protein: cdc25
Organism: Schizosaccharomyces pombe
Length: 596 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for cdc25.

Description E-value Query
Range
Subject
Range
gi|173361 - gi|173361|gb|AAA35294.1| mitosis initiation protein
532.0 [0..1] [579..1]
gi|248473 - gi|248473|gb|AAB22026.1| Cdc25M2 [Mus sp.]
MPIP2_MOUSE - M-phase inducer phosphatase 2 OS=Mus musculus GN=Cdc25b PE=1 SV=1
413.0 [0..64] [578..66]
gi|243486 - gi|243486|gb|AAB21139.1| p63 [Homo sapiens]
399.0 [0..64] [578..48]
gi|30584239, gi|... - gi|60653191|gb|AAX29290.1| cell division cycle 25B [synthetic construct], gi|30584239|gb|AAP36368.1|...
399.0 [0..64] [578..66]
gi|114680697 - gi|114680697|ref|XP_514487.2| PREDICTED: cell division cycle 25B isoform 18 [Pan troglodytes]
396.0 [0..64] [578..66]

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Predicted Domain #1
Region A:
Residues: [1-153]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MDSPLSSLSF TNTLSGKRNV LRPAARELKL MSDRNANQEL DFFFPKSKHI ASTLVDPFGK  60
   61 TCSTASPASS LAADMSMNMH IDESPALPTP RRTLFRSLSC TVETPLANKT IVSPLPESPS 120
  121 NDALTESYFF RQPASKYSIT QDSPRVSSTI AYS

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [154-203]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 FKPKASIALN TTKSEATRSS LSSSSFDSYL RPNVSRSRSS GNAPPFLRSR 

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [204-309]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SSSSYSINKK KGTSGGQATR HLTYALSRTC SQSSNTTSLL ESCLTDDTDD FELMSDHEDT  60
   61 FTMGKVADLP ESSVELVEDA ASIQRPNSDF GACNDNSLDD LFQASP

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

    MCM
Score
SCOP
Match
SCOP Description
View Download 0.417 a.60.2 RuvA domain 2-like
View Download 0.387 a.118.11 Cytochrome c oxidase subunit E
View Download 0.336 a.280.1 Description not found.
View Download 0.312 a.142.1 PTS-regulatory domain, PRD
View Download 0.301 c.55.1 Actin-like ATPase domain
View Download 0.295 a.118.9 ENTH/VHS domain
View Download 0.274 a.39.1 EF-hand
View Download 0.260 a.100.1 6-phosphogluconate dehydrogenase C-terminal domain-like
View Download 0.232 a.7.6 Ribosomal protein S20

Predicted Domain #4
Region A:
Residues: [310-352]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 IKPIDMLPKI NKDIAFPSLK VRSPSPMAFA MQEDAEYDEQ DTP

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

    MCM
Score
GO
Score
GO
Term
SCOP
Match
SCOP Description
View Download 0.232 N/A N/A a.37.1 A DNA-binding domain in eukaryotic transcription factors
View Download 0.227 N/A N/A b.34.1 C-terminal domain of transcriptional repressors
View Download 0.214 N/A N/A a.271.1 Description not found.
View Download 0.210 N/A N/A g.3.7 Scorpion toxin-like
View Download 0.201 N/A N/A g.3.7 Scorpion toxin-like

Predicted Domain #5
Region A:
Residues: [353-596]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 VLRRTQSMFL NSTRLGLFKS QDLVCVTPKQ STKESERFIS SHVEDLSLPC FAVKEDSLKR  60
   61 ITQETLLGLL DGKFKDIFDK CIIIDCRFEY EYLGGHISTA VNLNTKQAIV DAFLSKPLTH 120
  121 RVALVFHCEH SAHRAPHLAL HFRNTDRRMN SHRYPFLYYP EVYILHGGYK SFYENHKNRC 180
  181 DPINYVPMND ASHVMTCTKA MNNFKRNATF MRTKSYTFGQ SVLASPDVND SPTAMHSLST 240
  241 LRRF

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 50.69897
Match: 1cwrA
Description: CDC25b
Matching Structure (courtesy of the PDB):

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle