YRC Public Data Repository - Protein Structure Prediction

Protein:	SPBC8D2.15
Organism:	Schizosaccharomyces pombe
Length:	370 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for SPBC8D2.15.

Description	E-value	Query Range	Subject Range
gi\|7296306, gi\|1... - gi\|7296306\|gb\|AAF51596.1\| CG5231-PA, isoform A [Drosophila melanogaster], gi\|28380901\|gb\|AAO41414.1\|... gi\|220954722 - gi\|220954722\|gb\|ACL89904.1\| Las-PC [synthetic construct]	313.0	[0..2]	[364..8]
gi\|114593623 - gi\|114593623\|ref\|XP_526552.2\| PREDICTED: lipoic acid synthetase isoform 3 [Pan troglodytes]	307.0	[0..9]	[362..14]
LIAS - lipoic acid synthetase	307.0	[0..9]	[362..14]
gi\|57048078 - gi\|57048078\|ref\|XP_536255.1\| PREDICTED: similar to lipoic acid synthetase isoform 1 precursor isofor...	307.0	[0..9]	[363..14]
gi\|109074017 - gi\|109074017\|ref\|XP_001091994.1\| PREDICTED: similar to lipoic acid synthetase isoform 1 precursor is...	305.0	[0..9]	[362..14]
LIAS_RAT - Lipoyl synthase, mitochondrial OS=Rattus norvegicus GN=Lias PE=2 SV=1	304.0	[0..10]	[362..15]
LIAS_BOVIN - Lipoyl synthase, mitochondrial OS=Bos taurus GN=LIAS PE=2 SV=1	302.0	[0..9]	[362..14]
LIAS_MOUSE - Lipoyl synthase, mitochondrial OS=Mus musculus GN=Lias PE=1 SV=1	302.0	[0..10]	[362..15]

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Predicted Domain #1

Region A:
Residues: [1-370]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MLKIGRNATI LKNNFWFASV RFQSGGFSEK LAKGPSFADF LNMDKPLTAD EAFELDRKVE  60
   61 LPNGSIHKRL PSWLKTKVPL GTNFNRIKHD LRGSHLHTVC EEAKCPNIGE CWGGKDKSRA 120
  121 TATIMLMGDT CTRGCRFCSV KTSRRPGPLD PNEPENTAEA IKQWNLGYIV LTSVDRDDLT 180
  181 DLGANHIAKT IQKIKEKAPH ILVEALTPDF SGRMDLVEIV AKSGLDVFAH NVETVEELTP 240
  241 FVRDRRATYR QSLSVLKHVK KTCPHLITKT SIMLGLGETD AEILTTLKDL LEHNVDVVTF 300
  301 GQYMRPTKRH LKVQEYVHPK KFEYWKEVAE KLGFLYVASG PLVRSSYKAG EYFMENLIKK 360
  361 RSGNPASMSV

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	45.0
Match:	1r30A
Description:	The Crystal Structure of Biotin Synthase, an S-Adenosylmethionine-Dependent Radical Enzyme
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
sulfurtransferase activity	2.16438226990481	bayes_pls_golite062009
biotin synthase activity	2.08611410724267	bayes_pls_golite062009
coproporphyrinogen oxidase activity	1.98937742831419	bayes_pls_golite062009
radical SAM enzyme activity	1.93582371651697	bayes_pls_golite062009
catalytic activity	1.48331922124015	bayes_pls_golite062009
oxidoreductase activity, acting on the CH-CH group of donors, oxygen as acceptor	1.37188743230327	bayes_pls_golite062009
transferase activity, transferring sulfur-containing groups	1.13381681474815	bayes_pls_golite062009
binding	0.998331252589966	bayes_pls_golite062009
oxidoreductase activity	0.593156857804038	bayes_pls_golite062009
oxidoreductase activity, acting on the CH-CH group of donors	0.48341859452689	bayes_pls_golite062009
protein binding	0.274298596808905	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: