YRC Public Data Repository - Protein Structure Prediction

Protein:	gua1
Organism:	Schizosaccharomyces pombe
Length:	524 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for gua1.

Description	E-value	Query Range	Subject Range
IMDH2_YEAST - Inosine-5'-monophosphate dehydrogenase 2 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN... IMD2 - Inosine monophosphate dehydrogenase, catalyzes the rate-limiting step in GTP biosynthesis, expressio...	367.0	[0..1]	[524..1]
gi\|147736109, gi... - gi\|148270565\|ref\|YP_001245025.1\| inosine-5'-monophosphate dehydrogenase [Thermotoga petrophila RKU-1... gi\|254483680, gi... - gi\|254483680\|ref\|ZP_05096897.1\| inosine-5'-monophosphate dehydrogenase [Marinitoga piezophila KA3], ... gi\|4981907, gi\|1... - gi\|4981907\|gb\|AAD36418.1\|AE001789_3 inosine-5'-monophosphate dehydrogenase [Thermotoga maritima MSB8... gi\|7431403 - pir\|\|C72264 IMP dehydrogenase (EC 1.1.1.205) - Thermotoga maritima (strain MSB8)	362.0	[0..34]	[516..2]
gi\|7920698 - gi\|7920698\|gb\|AAF70813.1\|AF249293_1 putative inosine 5-monophosphate dehydrogenase [Candida albicans...	362.0	[0..4]	[524..2]
gi\|82500120, gi\|... - gi\|82500120\|ref\|ZP_00885547.1\| IMP dehydrogenase [Caldicellulosiruptor saccharolyticus DSM 8903], gi...	361.0	[0..30]	[519..5]
gi\|44983702 - gi\|44983702\|gb\|AAS52801.1\| AER117Wp [Ashbya gossypii ATCC 10895] gi\|44983702, gi\|... - gi\|45190723\|ref\|NP_984977.1\| AER117Wp [Ashbya gossypii ATCC 10895], gi\|44983702\|gb\|AAS52801.1\| AER11...	358.0	[0..3]	[524..2]

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Predicted Domain #1

Region A:
Residues: [1-524]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSAFKPYTEA LEVLKKYEKK DGLSIDDLIR HNFQGGLTFN DFLILPGYID FVPNNVSLET  60
   61 RISRNIVLKT PFMSSPMDTV TEDQMAIYMA LLGGIGVIHH NCTPEEQAAM VRKVKKYENG 120
  121 FILDPVVFSP QHTVGDVLKI KETKGFSGIP ITENGKLRGK LVGIVTSRDV QFHKDTNTPV 180
  181 TEVMTPREEL ITTAEGISLE RANEMLRKSK KGKLPVVDKD DNLVALLSLT DLMKNLHFPL 240
  241 ASKTSDTKQL MVAAAIGTRD DDRTRLALLA EAGLDAVVID SSQGNSCFQI EMIKWIKKTY 300
  301 PKIDVIAGNV VTREQTASLI AAGADGLRVG MGSGSACITQ EVMACGRPQA TAIAQVAEFA 360
  361 SQFGIGVIAD GGIQNVGHMV KSLSLGATAV MMGGLLAGTT ESPGEYYVRE GQRYKSYRGM 420
  421 GSIAAMEGTG VNKNASTGRY FSENDAVRVA QGVSGLVVDK GSLLRFLPYL YTGLQHALQD 480
  481 IGTKSLDELH EAVDKHEVRF ELRSSAAIRE GDIQGFATYE KRLY

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	94.39794
Match:	1b3oA
Description:	Inosine monophosphate dehydrogenase (IMPDH)
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
IMP dehydrogenase activity	2.02048863053452	bayes_pls_golite062009
binding	0.964202692685807	bayes_pls_golite062009
transporter activity	0.961062314616209	bayes_pls_golite062009
transmembrane transporter activity	0.807029018941177	bayes_pls_golite062009
substrate-specific transporter activity	0.640881170978843	bayes_pls_golite062009
substrate-specific transmembrane transporter activity	0.525366315833255	bayes_pls_golite062009
ion transmembrane transporter activity	0.440262824681055	bayes_pls_golite062009
protein binding	0.22179604283012	bayes_pls_golite062009
catalytic activity	0.181756622780318	bayes_pls_golite062009
di-, tri-valent inorganic cation transmembrane transporter activity	0.0973526732376297	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: