YRC Public Data Repository - Protein Structure Prediction

Protein:	his2
Organism:	Schizosaccharomyces pombe
Length:	439 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for his2.

Description	E-value	Query Range	Subject Range
gi\|3203 - gi\|3203\|emb\|CAA39641.1\| histidinol dehydrogenase; phosphoribosyl-AMP cyclohydrolase; phosphoribosyl-...	638.0	[0..2]	[439..404]
gi\|2623127 - gi\|2623127\|gb\|AAC53724.1\| histidinol dehydrogenase [Expression vector pIB4] gi\|2623118 - gi\|2623118\|gb\|AAC53718.1\| histidinol dehydrogenase [Expression vector pIB1] gi\|2623121 - gi\|2623121\|gb\|AAC53720.1\| histidinol dehydrogenase [Expression vector pIB2] gi\|2623124 - gi\|2623124\|gb\|AAC53722.1\| histidinol dehydrogenase [Expression vector pIB3]	631.0	[0..2]	[439..404]
gi\|4185813 - gi\|4185813\|gb\|AAD09196.1\| HMG1-SUC2-HIS4C protein [Shuttle vector pCS4-14]	624.0	[0..14]	[439..1188]
gi\|49524313 - gi\|49524313\|emb\|CAG57910.1\| unnamed protein product [Candida glabrata] gi\|50285163, gi\|... - gi\|50285163\|ref\|XP_445010.1\| unnamed protein product [Candida glabrata], gi\|49524313\|emb\|CAG57910.1\|...	618.0	[0..14]	[439..366]
gi\|194538746, gi... - gi\|75854240\|ref\|ZP_00761946.1\| COG0141: Histidinol dehydrogenase [Vibrio sp. Ex25], gi\|254230163\|ref...	617.0	[0..8]	[439..1]
gi\|91226030, gi\|... - gi\|91226030\|ref\|ZP_01260957.1\| histidinol dehydrogenase [Vibrio alginolyticus 12G01], gi\|91189471\|gb...	615.0	[0..8]	[439..1]
HIS4 - Multifunctional enzyme containing phosphoribosyl-ATP pyrophosphatase, phosphoribosyl-AMP cyclohydrol... HIS2_YEAST - Histidine biosynthesis trifunctional protein OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c...	614.0	[0..14]	[439..363]
gi\|1076975 - pir\|\|S53349 phosphoribosyl-AMP cyclohydrolase (EC 3.5.4.19) / phosphoribosyl-ATP diphosphatase (EC 3... HIS2_SACBA - Histidine biosynthesis trifunctional protein OS=Saccharomyces bayanus GN=HIS4 PE=3 SV=1	614.0	[0..14]	[439..363]

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Predicted Domain #1

Region A:
Residues: [1-439]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MPEYEIQVPS YRAAALTAEE RTRLLARPIQ NTQKIRTIVQ PIIEDVKSRG EASLIDYASK  60
   61 FEKVQLKSAV LKAPFDDDLM KISPMIKEDI DIAFNNIFAF HSSQLRPTIA VQTMRGVVCQ 120
  121 RMSRPINRVG LYIPGGTAVL PSTALMLGVP AKVAGCPHVV ISTPVRKDGT VAPEIVYIAN 180
  181 KIGAEAIILA GGAQAIAAMA YGISGVPKVN KIFGPGNQFV TAAKMHVQND YGALVAIDLP 240
  241 AGPSEVLVIA DETCNPESVA LDLLSQAEHG LDSQIILLTV SLSPEMFDRI QKAINDHALR 300
  301 LSRSYIIKHA IKKSVIVQVD NVDQAFEWSN LYGPEHLVLH LKNASSYIPK IDNAGSVFVG 360
  361 PWSPVSMGDY ASGTNHTLPT YGYASSYSGV STDSFLKYIT TQELTEEGIQ RLGPTVIRLA 420
  421 ELEGLTAHAD AVRVRGVRL

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	170.0
Match:	1k75A
Description:	L-histidinol dehydrogenase HisD
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
catalytic activity	2.80804701752928	bayes_pls_golite062009
histidinol dehydrogenase activity	2.32012109012499	bayes_pls_golite062009
oxidoreductase activity	2.31275077585879	bayes_pls_golite062009
oxidoreductase activity, acting on the aldehyde or oxo group of donors	2.24875477727877	bayes_pls_golite062009
oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor	2.22720948878196	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: