YRC Public Data Repository - Protein Structure Prediction

Protein:	fus1
Organism:	Schizosaccharomyces pombe
Length:	1372 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for fus1.

Description	E-value	Query Range	Subject Range
gi\|70984130, gi\|... - gi\|70984130\|ref\|XP_747584.1\| cytokinesis protein SepA/Bni1 [Aspergillus fumigatus Af293], gi\|6684521...	471.0	[0..35]	[1329..210]
gi\|116199253, gi... - gi\|88179061\|gb\|EAQ86529.1\| hypothetical protein CHGG_07782 [Chaetomium globosum CBS 148.51], gi\|1161...	464.0	[0..36]	[1223..148]
SEPA_EMENI - Cytokinesis protein sepA OS=Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194... SEPA_EMENI - Cytokinesis protein sepA OS=Emericella nidulans GN=sepA PE=3 SV=2	397.0	[0..27]	[619..177]
gi\|39944100, gi\|... - gi\|39944100\|ref\|XP_361587.1\| hypothetical protein MG04061.4 [Magnaporthe grisea 70-15], gb\|EAA50302....	394.0	[0..40]	[607..185]
gi\|67540706, gi\|... - gi\|67540706\|ref\|XP_664127.1\| SEPA_EMENI Cytokinesis protein sepA (FH1/2 protein) (Forced expression ...	392.0	[0..27]	[619..177]
gi\|85077228 - gi\|85077228\|ref\|XP_955991.1\| cytokinesis protein sepA [Neurospora crassa OR74A] gi\|32414781, gi\|... - gi\|32414781\|ref\|XP_327870.1\| hypothetical protein [Neurospora crassa], gi\|28917030\|gb\|EAA26755.1\| cy...	384.0	[0..30]	[624..201]
gi\|28950342 - gi\|28950342\|emb\|CAD70966.1\| probable Cytokinesis protein sepA [Neurospora crassa]	384.0	[0..30]	[624..201]
CDC12_SCHPO - Cell division control protein 12 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=cdc12 PE=... cdc12 - formin Cdc12	377.0	[0..6]	[1323..129]
gi\|42552609, gi\|... - gi\|46121675\|ref\|XP_385392.1\| hypothetical protein FG05216.1 [Gibberella zeae PH-1], gi\|42552609\|gb\|E...	377.0	[0..32]	[641..192]
gi\|71020115, gi\|... - gi\|71020115\|ref\|XP_760288.1\| hypothetical protein UM04141.1 [Ustilago maydis 521], ref\|XP_401756.1\| ...	361.0	[0..18]	[658..97]

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Predicted Domain #1

Region A:
Residues: [1-94]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MMTASFKGIR ISKPIVKEIS SFGSLTNIDL HTDPYEKVEA KALSRSRLKN QSVKKTDLRI  60
   61 TNDYSSLFVS IENKKNTIPD IHCNNLSKRP VGFT

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2

Region A:
Residues: [95-571]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DSYVPGEALL CPDDPNLVNE LFDDVLKRLR EEKSDSGEQF HWDANVTLSQ ENKWSFITGY  60
   61 LSRNDKFLKI SSNDSELNVK ASVISYIEKL SCTPLKLKYV ESLAVALRTE SVTWVRYFLL 120
  121 MGGHIVLAKI LQAIHEKKHL KSPDITLEIA ILKSMRCIIG QKIGTDFYLS NKYPIDSVVH 180
  181 CLLSTKLLVR KLAAELLTFL CYSEKPNGIN AIMKCMKNFA NLKVESMNVF DLWLSQWKRT 240
  241 LLEKVVTEEK KVLEEAALHD KITIEYIISQ MLLINAFLEN IPSKTALLQF KESLRIGNFK 300
  301 SILLILKKIN DEGVLKQLEK CVKLVSLDTA NEKHFLKHTP NSAAHQSLLN TNMFNDANFE 360
  361 FMVKEHIKNF LKLLKEHNNP VRIIKLLDCL VLTLQADKGN GNSNNDIDCF YKELKIGNEQ 420
  421 GNNAPGYSSV TSGYGTTNSK KVVASYDNTD DNEYSVSKSE LYATGDTNNT TNQGYEN

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	77.522879
Match:	1z2cB
Description:	Crystal structure of mDIA1 GBD-FH3 in complex with RhoC-GMPPNP
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
binding	2.27902748675387	bayes_pls_golite062009
protein binding	1.94427330399472	bayes_pls_golite062009
cytoskeletal protein binding	1.79889605917047	bayes_pls_golite062009
actin binding	1.58742487047757	bayes_pls_golite062009

Predicted Domain #3

Region A:
Residues: [572-642]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SERKYVESSK YETDLKNIFD CLCLLFPSEF DPQSSFSAEK IFSKLKHLLT RTRDSYISED  60
   61 TKILRLLNRS S

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #4

Region A:
Residues: [643-848]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SKLQDRDQEY LISKNNVNGN GNRDWVQPVN TTSSVSAFAS PRIKPKLLFQ PNQDEKLKLC  60
   61 KLDLAKANSI TLKSEPSSAV STHSFEVHLS MPGTQIKSAN LAEKMETSKH KVFNPKRIDV 120
  121 VSDLPLDYRK SYYGRFSITD TKRFSKIENM RIKEVIDGNP FKAPPPAPLP PPAPPLPTAM 180
  181 SSLQKFEKND SQIFRKTIII PENISI

[Run NCBI BLAST on this sequence.]

Detection Method:

MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #5

Region A:
Residues: [849-1282]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DDIFKFCSGS ESEVYASKIP GELCNPSKRL KQLHWKRLEV PFEKTLWNIV VADPYLLTLK  60
   61 LTAEGIFKQL EDCYPLREVT VSNKKVKEYT GFMPVDLQQM VSIRLHRFNS LTPIEIAKKF 120
  121 FHCDHDIMEL VDFFNDRKFF RQEGLKKQLK PYMSSRNEEV MEVSEKLLEL SRFDQIYTLI 180
  181 VVDIDTYYEK RMAALKIKSF LANNFRDFRR QIRKLHCASL ELKSSLHFKY FLNLVLHIGN 240
  241 FMNDAPRRAK GYRLESLLRA SMIKNDKTGL TLLHTIEKIV RTHFPQLEAF LVDLKAIPEI 300
  301 SRFNLEQLEQ DCNDICERMK NVEKDFSNEG IFSNHKALHP DDHICEVMVP WIPSGKSMVD 360
  361 ELNSDITELK TTLKTTLLMY GENPDEPTSS ARFFNNLNEI ILEYKKASTV NQKMEKEEEL 420
  421 AFLRLQALKA SVKS

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	38.39794
Match:	1y64B
Description:	Bni1p Formin Homology 2 Domain complexed with ATP-actin
Matching Structure (courtesy of the PDB):

Predicted Domain #6

Region A:
Residues: [1283-1372]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NNAENSGSSK NEEVSATMEN LISQLQKGLC DDSLSNKTDC TESSKQTIET LMNYENDKQT  60
   61 LEGSNKKRQT VVLKAECMLK QLENNNELKR

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	5.09691
Match:	1dg3A
Description:	Interferon-induced guanylate-binding protein 1 (GBP1), C-terminal domain; Interferon-induced guanylate-binding protein 1 (GBP1), N-terminal domain
Matching Structure (courtesy of the PDB):

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: