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View Structure Prediction Details

Protein: erg9
Organism: Schizosaccharomyces pombe
Length: 460 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for erg9.

Description E-value Query
Range
Subject
Range
gi|477750 - gi|477750|pir||B48057 farnesyl-diphosphate farnesyltransferase (EC 2.5.1.21) - fission yeast (Schizo...
500.0 [0..1] [460..1]
gi|38109584, gi|... - gi|39958237|ref|XP_364394.1| hypothetical protein MGG_09239 [Magnaporthe grisea 70-15], gb|EAA55432....
413.0 [0..4] [440..11]
FDFT_NEUCR - Probable squalene synthase OS=Neurospora crassa GN=erg-9 PE=3 SV=1
FDFT_NEUCR - Probable squalene synthase OS=Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1...
413.0 [0..4] [440..11]
FDFT_YEAST - Squalene synthase OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=ERG9 PE=1 SV=2
ERG9 - Farnesyl-diphosphate farnesyl transferase (squalene synthase), joins two farnesyl pyrophosphate moie...
412.0 [0..1] [447..5]
gi|67525837, gi|... - gi|67525837|ref|XP_660980.1| hypothetical protein AN3376.2 [Aspergillus nidulans FGSC A4], ref|XP_40...
412.0 [0..4] [439..10]
gi|2463569, gi|7... - pir||T05262 farnesyl-diphosphate farnesyltransferase (EC 2.5.1.21) - soybean, gi|2463569|dbj|BAA225...
409.0 [0..6] [446..10]
FDFT_CANGA - Squalene synthase OS=Candida glabrata GN=ERG9 PE=3 SV=2
FDFT_CANGA - Squalene synthase OS=Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65...
408.0 [0..1] [446..5]
gi|9955387 - gi|9955387|dbj|BAB12207.1| squalene synthase [Candida glabrata]
408.0 [0..1] [446..5]

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Predicted Domain #1
Region A:
Residues: [1-399]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSLANRIEEI RCLCQYKLWN DLPSYGEDEN VPQNIRRCYQ LLDMTSRSFA VVIKELPNGI  60
   61 REAVMIFYLV LRGLDTVEDD MTLPLDKKLP ILRDFYKTIE VEGWTFNESG PNEKDRQLLV 120
  121 EFDVVIKEYL NLSEGYRNVI SNITKEMGDG MAYYASLAEK NDGFSVETIE DFNKYCHYVA 180
  181 GLVGIGLSRL FAQSKLEDPD LAHSQAISNS LGLFLQKVNI IRDYREDFDD NRHFWPREIW 240
  241 SKYTSSFGDL CLPDNSEKAL ECLSDMTANA LTHATDALVY LSQLKTQEIF NFCAIPQVMA 300
  301 IATLAAVFRN PDVFQTNVKI RKGQAVQIIL HSVNLKNVCD LFLRYTRDIH YKNTPKDPNF 360
  361 LKISIECGKI EQVSESLFPR RFREMYEKAY VSKLSEQKK

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 85.39794
Match: 1ezfA
Description: Squalene synthase
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
prenyltransferase activity 5.34003736022396 bayes_pls_golite062009
farnesyl-diphosphate farnesyltransferase activity 5.04441642023356 bayes_pls_golite062009
geranyltranstransferase activity 3.86169009960142 bayes_pls_golite062009
farnesyltranstransferase activity 3.11591733497708 bayes_pls_golite062009
catalytic activity 2.4040324437254 bayes_pls_golite062009
dimethylallyltranstransferase activity 1.91559289231283 bayes_pls_golite062009
transferase activity, transferring alkyl or aryl (other than methyl) groups 1.82540911622956 bayes_pls_golite062009
transferase activity 1.77738506203957 bayes_pls_golite062009
binding 0.0206192709356209 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [400-460]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GNGTQKAILN DEQKELYRKD LQKLGISILF VFFIILVCLA VIFYVFNIRI HWSDFKELNL  60
   61 F

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle