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View Structure Prediction Details

Protein: cap1
Organism: Schizosaccharomyces pombe
Length: 551 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for cap1.

Description E-value Query
Range
Subject
Range
gi|55729652 - gi|55729652|emb|CAH91555.1| hypothetical protein [Pongo abelii]
gi|197098662 - gi|197098662|ref|NP_001125913.1| CAP, adenylate cyclase-associated protein, 2 [Pongo abelii]
686.0 [0..68] [549..8]
gi|60653725 - gi|60653725|gb|AAX29556.1| adenylate cyclase-associated protein 2 [synthetic construct]
685.0 [0..68] [549..8]
gi|109069713 - gi|109069713|ref|XP_001095462.1| PREDICTED: similar to adenylyl cyclase-associated protein 2 isoform...
685.0 [0..68] [549..8]
CAP2 - CAP, adenylate cyclase-associated protein, 2 (yeast)
gi|61361754, gi|... - gi|61361754|gb|AAX42098.1| CAP adenylate cyclase-associated protein 2 [synthetic construct], gi|1239...
685.0 [0..68] [549..8]
gi|114605601, gi... - gi|114605601|ref|XP_001170453.1| PREDICTED: adenylyl cyclase-associated protein 2 isoform 6 [Pan tro...
683.0 [0..68] [549..8]
CAP2_MOUSE - Adenylyl cyclase-associated protein 2 OS=Mus musculus GN=Cap2 PE=1 SV=1
682.0 [0..65] [549..5]
gi|50733649 - gi|50733649|ref|XP_418936.1| PREDICTED: similar to adenylyl cyclase-associated protein 2; 2810452G09...
680.0 [0..69] [549..9]

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Predicted Domain #1
Region A:
Residues: [1-85]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSDMINIRET GYNFTTILKR LEAATSRLED LVESGHKPLP NMHRPSRDSN SQTHNISFNI  60
   61 GTPTAPTVST GSPAVASLHD QVAAA

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [86-328]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ISPRNRSLTS TSAVEAVPAS ISAYDEFCSK YLSKYMELSK KIGGLIAEQS EHVEKAFNLL  60
   61 RQVLSVALKA QKPDMDSPEL LEFLKPIQSE LLTITNIRDE HRTAPEFNQL STVMSGISIL 120
  121 GWVTVEPTPL SFMSEMKDSS QFYANRVMKE FKGKDDLQIE WVRSYLTLLT ELITYVKTHF 180
  181 KTGLTWSTKQ DAVPLKTALA NLSASKTQAP SSGDSANGGL PPPPPPPPPS NDFWKDSNEP 240
  241 APA

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 67.69897
Match: 1tjfA
Description: The crystal structure of the N-terminal domain of CAP indicates variable oligomerisation
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
actin binding 5.81884714997094 bayes_pls_golite062009
cytoskeletal protein binding 4.39652693178112 bayes_pls_golite062009
adenylate cyclase binding 2.08284870927262 bayes_pls_golite062009
binding 1.8340549733034 bayes_pls_golite062009
enzyme binding 1.53072876683435 bayes_pls_golite062009
protein binding 0.871734119777931 bayes_pls_golite062009

Predicted Domain #3
Region A:
Residues: [329-394]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DNKGDMGAVF AEINKGEGIT SGLRKVDKSE MTHKNPNLRK TGPTPGPKPK IKSSAPSKPA  60
   61 ETAPVK

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #4
Region A:
Residues: [395-551]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PPRIELENTK WFVENQVDNH SIVLDSVELN HSVQIFGCSN CTIIIKGKLN TVSMSNCKRT  60
   61 SVVVDTLVAA FDIAKCSNFG CQVMNHVPMI VIDQCDGGSI YLSKSSLSSE VVTSKSTSLN 120
  121 INVPNEEGDY AERAVPEQIK HKVNEKGELV SEIVRHE

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 76.221849
Match: 1k8fA
Description: C-terminal domain of adenylylcyclase associated protein
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
actin binding 4.94933252861141 bayes_pls_golite062009
cytoskeletal protein binding 4.21664682046338 bayes_pls_golite062009
actin monomer binding 2.04365563273836 bayes_pls_golite062009
binding 1.57578562719958 bayes_pls_golite062009
adenylate cyclase binding 1.13353932343086 bayes_pls_golite062009
enzyme binding 0.705135358375 bayes_pls_golite062009
protein binding 0.651719649953198 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle