YRC Public Data Repository - Protein Structure Prediction

Protein:	brx1
Organism:	Schizosaccharomyces pombe
Length:	295 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for brx1.

Description	E-value	Query Range	Subject Range
BRX1_BOVIN - Ribosome biogenesis protein BRX1 homolog OS=Bos taurus GN=BRIX1 PE=2 SV=1	284.0	[0..6]	[294..18]
gi\|74212210 - gi\|74212210\|dbj\|BAE40264.1\| unnamed protein product [Mus musculus]	280.0	[0..6]	[294..21]
BRX1_XENLA - Ribosome biogenesis protein BRX1 homolog OS=Xenopus laevis GN=brix1 PE=2 SV=1	279.0	[0..3]	[294..2]
gi\|114600702 - gi\|114600702\|ref\|XP_517812.2\| PREDICTED: similar to Brix domain containing 2 [Pan troglodytes]	277.0	[0..37]	[294..28]
BRX1_RAT - Ribosome biogenesis protein BRX1 homolog OS=Rattus norvegicus GN=Brix1 PE=2 SV=1	277.0	[0..6]	[294..21]
gi\|71895385, gi\|... - gi\|71895385\|ref\|NP_001026620.1\| BRIX [Gallus gallus], gi\|53128255\|emb\|CAG31284.1\| hypothetical prote...	276.0	[0..8]	[294..18]
gi\|123982586, gi... - gi\|123997253\|gb\|ABM86228.1\| brix domain containing 2 [synthetic construct], gi\|123982586\|gb\|ABM83034... BRIX1 - BRX1, biogenesis of ribosomes, homolog (S. cerevisiae)	275.0	[0..36]	[294..53]
gi\|33604118 - gi\|33604118\|gb\|AAH56279.1\| Bxdc2 protein [Danio rerio]	275.0	[0..35]	[294..62]

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Predicted Domain #1

Region A:
Residues: [1-136]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSTVYKLKTS ERAPKNEDED EEYVPVQNGQ GNKHSAGFVP IKQKVLVLSS RGVTYRQRHL  60
   61 LNDLVSMMPH SKKDSKLDSK DRLYQLNELA ELYNCNNIFF FESRRREDLY LHIARAPNGP 120
  121 TVKFHVENLH TMDELN

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	13.045757
Match:	2cxhA
Description:	Crystal structure of probable ribosomal biogenesis protein from Aeropyrum pernix K1
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
aminoacyl-tRNA ligase activity	3.87211694771248	bayes_pls_golite062009
ligase activity, forming carbon-oxygen bonds	3.87184649959884	bayes_pls_golite062009
ligase activity, forming aminoacyl-tRNA and related compounds	3.87184649959884	bayes_pls_golite062009
ligase activity	2.64230127203047	bayes_pls_golite062009
proline-tRNA ligase activity	2.35871952544841	bayes_pls_golite062009
binding	1.78917266819015	bayes_pls_golite062009
catalytic activity	0.902495165806215	bayes_pls_golite062009
protein binding	0.665778090365515	bayes_pls_golite062009

Predicted Domain #2

Region A:
Residues: [137-295]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTGNALKGSR PILSFDKTFD TAPHLKVVKE LLQQTFGIPK GARRSKPFID RVCTLTIADG  60
   61 KIWFRNYEIR ENEDKSKDPV TLIEIGPRFV MTIINILEGS FGGPVIYKND TFVSSTMVRA 120
  121 AIRNQAAQRY VNRQESKLER QVRAQQNVIP EDPLDNVFA

[Run NCBI BLAST on this sequence.]

Detection Method:	FFAS03
Confidence:	1.67
Match:	2cxhA
Description:	Crystal structure of probable ribosomal biogenesis protein from Aeropyrum pernix K1
Matching Structure (courtesy of the PDB):

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: