YRC Public Data Repository - Protein Structure Prediction

Protein:	bio2
Organism:	Schizosaccharomyces pombe
Length:	363 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for bio2.

Description	E-value	Query Range	Subject Range
gi\|2961328 - gi\|2961328\|emb\|CAA12229.1\| Biotin synthase [Schizosaccharomyces pombe]	280.0	[0..1]	[363..1]
gi\|85693260, gi\|... - gi\|85712880\|ref\|ZP_01043921.1\| Biotin synthase [Idiomarina baltica OS145], gi\|85693260\|gb\|EAQ31217.1...	279.0	[0..16]	[354..6]
gi\|49086966 - gi\|49086966\|gb\|AAT51401.1\| PA0500 [synthetic construct]	277.0	[0..17]	[357..7]
gi\|126169206, gi... - gi\|84318723\|ref\|ZP_00967143.1\| COG0502: Biotin synthase and related enzymes [Pseudomonas aeruginosa ...	276.0	[0..17]	[357..7]
gi\|254243593, gi... - gi\|84324269\|ref\|ZP_00972330.1\| COG0502: Biotin synthase and related enzymes [Pseudomonas aeruginosa ... BIOB_PSEA8 - Biotin synthase OS=Pseudomonas aeruginosa (strain LESB58) GN=bioB PE=3 SV=1 gi\|107099486 - gi\|107099486\|ref\|ZP_01363404.1\| hypothetical protein PaerPA_01000498 [Pseudomonas aeruginosa PACS2] BIOB_PSEAE - Biotin synthase OS=Pseudomonas aeruginosa GN=bioB PE=3 SV=1 BIOB_PSEAE - Biotin synthase OS=Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228) GN=b...	276.0	[0..17]	[357..7]
BIOB_PSEAB - Biotin synthase OS=Pseudomonas aeruginosa (strain UCBPP-PA14) GN=bioB PE=3 SV=1	275.0	[0..17]	[357..7]
BIOB_PSEA7 - Biotin synthase OS=Pseudomonas aeruginosa (strain PA7) GN=bioB PE=3 SV=1	274.0	[0..12]	[358..2]
gi\|70732978, gi\|... - gi\|70732978\|ref\|YP_262751.1\| biotin synthetase [Pseudomonas fluorescens Pf-5], gi\|68347277\|gb\|AAY948...	272.0	[0..4]	[357..24]
gi\|226942753, gi... - gi\|67156983\|ref\|ZP_00418345.1\| Biotin synthase [Azotobacter vinelandii AvOP], gi\|67085660\|gb\|EAM0513... gi\|67156983, gi\|... - gi\|67156983\|ref\|ZP_00418345.1\| Biotin synthase [Azotobacter vinelandii AvOP], ref\|ZP_00090881.2\| COG...	272.0	[0..17]	[358..6]
BIOB_PSEP1 - Biotin synthase OS=Pseudomonas putida (strain F1 / ATCC 700007) GN=bioB PE=3 SV=1	271.0	[0..20]	[357..10]

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Predicted Domain #1

Region A:
Residues: [1-363]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MFTRTIRQQI RRSSALSLVR NNWTREEIQK IYDTPLIDLI FRAASIHRKF HDPKKVQQCT  60
   61 LLSIKTGGCT EDCKYCAQSS RYNTGVKATK LMKIDEVLEK AKIAKAKGST RFCMGSAWRD 120
  121 LNGRNRTFKN ILEIIKEVRS MDMEVCVTLG MLNEQQAKEL KDAGLTAYNH NLDTSREYYS 180
  181 KIISTRTYDE RLNTIDNLRK AGLKVCSGGI LGLGEKKHDR VGLIHSLATM PTHPESVPFN 240
  241 LLVPIPGTPV GDAVKERLPI HPFLRSIATA RICMPKTIIR FAAGRNTCSE SEQALAFMAG 300
  301 ANAVFTGEKM LTTPAVSWDS DSQLFYNWGL EGMQSFEYGT STEGEDGTFT LPPKERLAPS 360
  361 PSL

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	71.69897
Match:	1r30A
Description:	The Crystal Structure of Biotin Synthase, an S-Adenosylmethionine-Dependent Radical Enzyme
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
biotin synthase activity	4.96431653338581	bayes_pls_golite062009
radical SAM enzyme activity	4.81217611621334	bayes_pls_golite062009
sulfurtransferase activity	3.43375708969779	bayes_pls_golite062009
transferase activity, transferring sulfur-containing groups	2.79703059227143	bayes_pls_golite062009
coproporphyrinogen oxidase activity	1.98937742831419	bayes_pls_golite062009
catalytic activity	1.48331922124015	bayes_pls_golite062009
oxidoreductase activity, acting on the CH-CH group of donors, oxygen as acceptor	1.37188743230327	bayes_pls_golite062009
binding	1.19681284943457	bayes_pls_golite062009
oxidoreductase activity, acting on the CH-CH group of donors	1.18901545014659	bayes_pls_golite062009
transferase activity	0.685192555939835	bayes_pls_golite062009
oxidoreductase activity	0.593156857804038	bayes_pls_golite062009
protein binding	0.374124957429525	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: