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View Structure Prediction Details

Protein: RunxB-PB
Organism: Drosophila melanogaster
Length: 306 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for RunxB-PB.

Description E-value Query
Range
Subject
Range
gi|83405621 - gi|83405621|gb|AAI10829.1| RUNX1 protein [Homo sapiens]
366.0 [0..53] [303..2]

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Predicted Domain #1
Region A:
Residues: [1-96]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MHISAEVSST TSNQIQQQQQ QHQQQQQHQL LQHQQQQTAT TTTTKRRNAE SSASSNNNNN  60
   61 NNTSTTNNNN TNNNNNSTTN NNNNNNNNNV KTKPVD

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [97-306]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 TSPYLTPENL IERTVDVLLA EHPGELVKTG SPHVVCTTLP THWRSNKTLP IAFKVLALGE  60
   61 VMDGTIVTIR AGNDENFCGE LRNCTAVMKN QVAKFNDLRF VGRSGRGKSF TLTIVISTNP 120
  121 IQIATYTKAI KVTVDGPREP RSKVRHQGFH PFAFGPQRFG PDPLMAGLPF KLPGKRKRWR 180
  181 RFRGNQGFGR LKRKHRRHTE RNSGYSISLK 

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 77.69897
Match: 1e50A
Description: Acute myeloid leukemia 1 protein (AML1), RUNT domain
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
binding 1.13591399970354 bayes_pls_golite062009
nucleic acid binding 0.54158309583174 bayes_pls_golite062009
DNA binding 0.53363287856737 bayes_pls_golite062009
transcription regulator activity 0.3602964037518 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle