YRC Public Data Repository - Protein Structure Prediction

Protein:	fh-PA
Organism:	Drosophila melanogaster
Length:	190 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for fh-PA.

Description	E-value	Query Range	Subject Range
FRDA_MOUSE - Frataxin, mitochondrial OS=Mus musculus GN=Fxn PE=1 SV=1	235.0	[0..2]	[188..4]
gi\|38048059 - gi\|38048059\|gb\|AAR09932.1\| similar to Drosophila melanogaster fh [Drosophila yakuba]	231.0	[0..1]	[172..1]
gi\|109463707 - gi\|109463707\|ref\|XP_001078791.1\| PREDICTED: similar to Frataxin, mitochondrial precursor (Fxn) [Ratt...	222.0	[0..2]	[188..4]
gi\|11559522 - gi\|11559522\|gb\|AAG37996.1\|AF209098_1 frataxin-like protein [Drosophila subobscura]	204.0	[0..1]	[190..1]
FXN - frataxin	204.0	[0..16]	[188..23]
gi\|109111727 - gi\|109111727\|ref\|XP_001093449.1\| PREDICTED: similar to frataxin isoform 1 preproprotein [Macaca mula...	203.0	[0..13]	[188..38]
FRDA_MACFA - Frataxin, mitochondrial OS=Macaca fascicularis GN=FXN PE=2 SV=1	199.0	[0..13]	[188..38]

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Predicted Domain #1

Region A:
Residues: [1-190]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MFAGRLMVRS IVGRACLATM GRWSKPQAHA SQVILPSTPA IAAVAIQCEE FTANRRLFSS  60
   61 QIETESTLDG ATYERVCSDT LDALCDYFEE LTENASELQG TDVAYSDGVL TVNLGGQHGT 120
  121 YVINRQTPNK QIWLSSPTSG PKRYDFVGTV AAGRWIYKHS GQSLHELLQQ EIPGILKSQS 180
  181 VDFLRLPYCS

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Detection Method:	PSI-BLAST
Confidence:	43.154902
Match:	1ekgA
Description:	C-terminal domain of frataxin
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
ferric iron binding	3.17697632477325	bayes_pls_golite062009
iron chaperone activity	3.06653945752385	bayes_pls_golite062009
iron ion binding	2.78584553912929	bayes_pls_golite062009
metallochaperone activity	1.67572555512957	bayes_pls_golite062009
ferrous iron binding	1.61332056179381	bayes_pls_golite062009
binding	1.55331726001774	bayes_pls_golite062009
transition metal ion binding	1.42179197342125	bayes_pls_golite062009
cation binding	1.42164579673909	bayes_pls_golite062009
metal ion binding	1.42164579673909	bayes_pls_golite062009
ion binding	1.4150396069236	bayes_pls_golite062009
protein binding	0.356112453590986	bayes_pls_golite062009
ferroxidase activity	0.310374472796773	bayes_pls_golite062009
oxidoreductase activity, oxidizing metal ions, oxygen as acceptor	0.310374472796773	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: