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View Structure Prediction Details

Protein: fs(1)h-PB
Organism: Drosophila melanogaster
Length: 2038 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for fs(1)h-PB.

Description E-value Query
Range
Subject
Range
gi|280611, gi|15... - pir||A43742 female sterile homeotic protein, 205K - fruit fly (Drosophila melanogaster), gi|157453...
755.0 [0..1] [2038..1]

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Predicted Domain #1
Region A:
Residues: [1-140]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSSSEPPPRY EPPVEPVNGI VQPPVIPPAE RPGRNTNQLQ YLIKTVMKVI WKHHFSWPFQ  60
   61 QPVDAKKLNL PDYHKIIKQP MDMGTIKKRL ENNYYWSAKE TIQDFNTMFN NCYVYNKPGE 120
  121 DVVVMAQTLE KVFLQKIESM 

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 49.0
Match: 1x0jA
Description: No description for 1x0jA was found.

Predicted Domain #2
Region A:
Residues: [141-308]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PKEELELEPV TAKGGKKKQR APATPKSSSG GAGASTGSGT SSAAVTSGPG SGSTKVSVAA  60
   61 SSAQQSGLQG ATGAGGGSSS TPGTQPGSGA GGAIAARPVS AMGGTVSSTA GGAPSIPPIS 120
  121 TMPPHTVPGS TNTTTTAMAG GVGGPGAAGA NPNAAALMAS LLNAGQTG

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [309-448]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 AYPGAPGQTA VNSSSLLDGS TAAVAAAAAA AAAAAAAAGG AAGAAGGAGT IPAVAVNAAN  60
   61 AVQAYVNAGV SVGVDAVIPP QQPAKIKKGV KRKADTTTPT ANAFESPYTQ MDSKSAKIAT 120
  121 RRESNRQDLT FQGSGYNMSP 

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #4
Region A:
Residues: [449-586]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LGVSGVPGLG GLVAGGVAGV AVAKNKEKLS DALKSCNEIL KELFSKKHSG YAWPFYKPVD  60
   61 AEMLGLHDYH DIIKKPMDLG TVKRKMDNRE YKSAPEFAAD VRLIFTNCYK YNPPDHDVVA 120
  121 MGRKLQDVFE MRYANIPD

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 52.69897
Match: 2ouoA
Description: No description for 2ouoA was found.

Predicted Domain #5
Region A:
Residues: [587-967]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 EPVANAAHHH GHGHGHGHGH GHGHGHGHGH GHGHGYGGSS SLKHDASDSS SEDSSDTENE  60
   61 SNSDEERSAR LKMLESKLLG LQEEIRKLSE EASAKKKAKK KLKEKKKSIG GGSGSGSASH 120
  121 HCHATGGGAN AGGAGGPGSG GHGSVSVPGG VGSLGPGGAG GANLNALLGG SLVGHGGAAV 180
  181 AGGVPNVGAL HSQVHDVAMA FSQMAGGGAA AGAGFGAGVT AAGASSGGKA GTLAGALAAG 240
  241 AAAGAGGTTA GSGSSKGAKS KGGRGAKGSG AGGVGASNNA AAGNAAGGAA GAAAGAGSVG 300
  301 GVGGAGAAGG GNASKRAKGS SSAGAGGGVG GANASAGGAG ARGSSKKKPS QVMNFDSEEE 360
  361 DTAKPMSYDE KRQLSLDINK L

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 28.30103
Match: 1y0fA
Description: No description for 1y0fA was found.

Predicted Domain #6
Region A:
Residues: [968-1067]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PGDKLGRVVH IIQNREPSLR DSNPDEIEID FETLKPSTLR ELESYVASCL RKKTHKKPSG  60
   61 KSKDEQMAEK KQELEKRLQD VTGQLGASKK TAKKDESASS 

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 11.39794
Match: 2j7tA
Description: No description for 2j7tA was found.

Predicted Domain #7
Region A:
Residues: [1068-1240]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KVEAVQPANP VSSSSSSSDS SSSSSSDSSS SDSSDSEAGD GDERPPRKKK SRDSNGSNVN  60
   61 NPSINVVMGG NLPSGALSPT TMLMGLDHVV NSNTPTSQMS NMLGNANPLT AAAMLNNNNK 120
  121 TSLPGSNFGG APAPGNMMHA GAGVPVAGAA VSASTGQQHN KNGPNDLSKV QPG

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #8
Region A:
Residues: [1241-1620]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GPINAALPPH SFAGGTATVA TSQSSGGIRI ASNLHKPSGL GGGDLGEHHA ALAAALTSGI  60
   61 NSTGTAGGGI NNNGGSNNNA NPLGGSHGDA MVNASLASLA SGLKQIPQFD DPVEQSLASL 120
  121 EFSAGSTGKS GLTDNFLMQQ HLMQPAGPQQ QQQQQQQQPF GHQQQQQQQQ QQQQQQQQHM 180
  181 DYVTELLSKG AENVGGMNGN HLLNFNLDMA AAYQQKHPQQ QQQQAHNNGF NVADFGMAGF 240
  241 DGLNMTAASF LDLEPSLQQQ QMQQMQLQQQ HHQQQQQQTH QQQQQHQQQH HQQQQQQQLT 300
  301 QQQLQQQQQQ QQQQQHLQQQ QHQQQHHQAA NKLLIIPKPI ESMMPSPPDK QQLQQHQKVL 360
  361 PPQQSPSDMK LHPNAAAAAA 

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 15.154902
Match: 1i84S
Description: Heavy meromyosin subfragment
Matching Structure (courtesy of the PDB):

Predicted Domain #9
Region A:
Residues: [1621-1739]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 VASAQAKLVQ TFKANEQNLK NASSWSSLAS ANSPQSHTSS SSSSSKAKPA MDSFQQFRNK  60
   61 AKERDRLKLL EAAEKEKKNQ KEAAEKEQQR KHHKSSSSSL TSAAVAQAAA IAAATAAAA

[Run NCBI BLAST on this sequence.]

Detection Method: FFAS03
Confidence: 1.04
Match: 1rw6A
Description: human APP core domain
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
binding 0.225375777463061 bayes_pls_golite062009

Predicted Domain #10
Region A:
Residues: [1740-1822]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 VTLGAAAAAA LASSASNPSG GSSSGGAGST SQQAITGDRD RDRDRERERE RSGSGGGQSG  60
   61 NGNNSSNSAN SNGPGSAGSG GSG

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #11
Region A:
Residues: [1823-2038]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GGGGSGPASA GGPNSGGGGT ANSNSGGGGG GGGPALLNAG SNSNSGVGSG GAASSNSNSS  60
   61 VGGIVGSGGP GSNSQGSSGG GGGGPASGGG MGSGAIDYGQ QVAVLTQVAA NAQAQHVAAA 120
  121 VAAQAILAAS PLGAMESGRK SVHDAQPQIS RVEDIKASPG GQGQSSPAQQ SPQDRAAAKR 180
  181 AEQRRAEQER RRREALAGQI DMNMQSDLMA AFEETL

[Run NCBI BLAST on this sequence.]

Detection Method: FFAS03
Confidence: 1.23
Match: 1wckA
Description: Crystal structure of the C-terminal domain of BclA, the major antigen of the exosporium of the Bacillus anthracis spore.
Matching Structure (courtesy of the PDB):

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle