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View Structure Prediction Details

Protein: CG4045-PA
Organism: Drosophila melanogaster
Length: 256 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for CG4045-PA.

Description E-value Query
Range		 Subject
Range
CE03770 - status:Partially_confirmed UniProt:Q23126 protein_id:CAA91400.1
 184.0 [0..10] [256..5]
TRMB_KLULA - tRNA (guanine-N(7)-)-methyltransferase OS=Kluyveromyces lactis GN=TRM8 PE=3 SV=1
TRMB_KLULA - tRNA (guanine-N(7)-)-methyltransferase OS=Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70...
 179.0 [0..5] [256..9]
TRMB_YEAST - tRNA (guanine-N(7)-)-methyltransferase OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=T...
TRM8 - Subunit of a tRNA methyltransferase complex composed of Trm8p and Trm82p that catalyzes 7-methylguan...
TRMB_YEAS1 - tRNA (guanine-N(7)-)-methyltransferase OS=Saccharomyces cerevisiae (strain RM11-1a) GN=TRM8 PE=3 SV=...
 178.0 [0..29] [256..47]
TRMB_CANGA - tRNA (guanine-N(7)-)-methyltransferase OS=Candida glabrata GN=TRM8 PE=3 SV=1
TRMB_CANGA - tRNA (guanine-N(7)-)-methyltransferase OS=Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / ...
 174.0 [0..29] [256..46]
TRMB_ASHGO - tRNA (guanine-N(7)-)-methyltransferase OS=Ashbya gossypii GN=TRM8 PE=3 SV=1
TRMB_ASHGO - tRNA (guanine-N(7)-)-methyltransferase OS=Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 992...
 174.0 [0..17] [256..31]
TRMB_YARLI - tRNA (guanine-N(7)-)-methyltransferase OS=Yarrowia lipolytica GN=TRM8 PE=3 SV=1
TRMB_YARLI - tRNA (guanine-N(7)-)-methyltransferase OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=TRM8 PE=3...
 171.0 [0..23] [255..54]
gi|40882342 - gi|40882342|emb|CAF06164.1| probable t-RNA methyltransferase [Neurospora crassa]
 171.0 [0..8] [256..2]
gi|68477305, gi|... - gi|68477464|ref|XP_717203.1| potential tRNA methyltransferase Trm8p [Candida albicans SC5314], gi|68...
orf19.11279, orf... - orf19.3798 CGDID:CAL0001314 Assembly 19, Contig19-10192 (54253, 55323) CDS, translated using codon t...
 169.0 [0..10] [256..84]
gi|90412031, gi|... - gi|90412031|ref|ZP_01220038.1| tRNA (guanine-N(7)-)-methyltransferase [Photobacterium profundum 3TCK...
 169.0 [0..1] [252..1]
TRMB_CAEBR - tRNA (guanine-N(7)-)-methyltransferase OS=Caenorhabditis briggsae GN=CBG02883 PE=3 SV=1
gi|157751364 - gi|157751364|ref|XP_001679394.1| Hypothetical protein CBG02883 [Caenorhabditis briggsae AF16]
 168.0 [0..10] [256..5]

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Predicted Domain #1
Region A:
Residues: [1-256] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MVATGGQAQD QGQNQEPDVL NPTSAVTGLP QKRYYRQRAH SNPIADHSFD YPARPEDVDW  60
   61 RSMYPGIQQG QQVSFADIGC GYGGFLVTLG EMFPEKLSIG MEIRVKVSDY VVDRIAALRR 120
  121 RCADTGAYQN IACLRTNAMK YLPNYFVKGQ LEKMFFLYPD PHFKRAKHKW RIINQALLSE 180
  181 YAYILRKGGL LYTMTDVEDL HKWIVTHMEE HPLYERLTEE EANADPITPK LYQSSEEGAK 240
  241 VVRNKGDHFL AIFRRL

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 30.69897
Match: 1yzhA
Description: Crystal Structure of the Conserved Hypothetical Protein, Methyltransferase from Streptococcus pneumoniae TIGR4
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
methyltransferase activity 4.15445027778357 bayes_pls_golite062009
N-methyltransferase activity 4.07806017452628 bayes_pls_golite062009
transferase activity, transferring one-carbon groups 4.07153733729662 bayes_pls_golite062009
protein methyltransferase activity 3.92746815303714 bayes_pls_golite062009
S-adenosylmethionine-dependent methyltransferase activity 3.39429041855776 bayes_pls_golite062009
RNA methyltransferase activity 3.07428840534971 bayes_pls_golite062009
histone methyltransferase activity 2.99461585647365 bayes_pls_golite062009
tRNA methyltransferase activity 2.5931020126592 bayes_pls_golite062009
DNA-methyltransferase activity 2.43145108778901 bayes_pls_golite062009
arginine N-methyltransferase activity 2.41876112831625 bayes_pls_golite062009
protein-arginine N-methyltransferase activity 2.41876112831625 bayes_pls_golite062009
rRNA methyltransferase activity 2.29640050660273 bayes_pls_golite062009
transferase activity 2.22303238506686 bayes_pls_golite062009
histone-arginine N-methyltransferase activity 2.04296107639729 bayes_pls_golite062009
tRNA (cytosine-5-)-methyltransferase activity 1.88889414729709 bayes_pls_golite062009
tRNA (cytosine)-methyltransferase activity 1.88889414729709 bayes_pls_golite062009
protein-arginine omega-N monomethyltransferase activity 1.66871163498737 bayes_pls_golite062009
tRNA (adenine-N1-)-methyltransferase activity 1.53559006858264 bayes_pls_golite062009
tRNA (adenine)-methyltransferase activity 1.53559006858264 bayes_pls_golite062009
catalytic activity 1.25333584501255 bayes_pls_golite062009
histone methyltransferase activity (H4-R3 specific) 1.1103522853299 bayes_pls_golite062009
transcription regulator activity 0.914549843668268 bayes_pls_golite062009
protein-arginine omega-N asymmetric methyltransferase activity 0.89325812193225 bayes_pls_golite062009
DNA binding 0.86027591375666 bayes_pls_golite062009
rRNA (guanine) methyltransferase activity 0.720972789045101 bayes_pls_golite062009
site-specific DNA-methyltransferase (adenine-specific) activity 0.703178429468566 bayes_pls_golite062009
nucleic acid binding 0.616949327277483 bayes_pls_golite062009
rRNA (adenine) methyltransferase activity 0.533090627724779 bayes_pls_golite062009
rRNA (adenine-N6,N6-)-dimethyltransferase activity 0.455449410561251 bayes_pls_golite062009
RNA binding 0.417524996559564 bayes_pls_golite062009
binding 0.383237930789959 bayes_pls_golite062009
tRNA (guanine) methyltransferase activity 0.203168546434167 bayes_pls_golite062009
rRNA (uridine) methyltransferase activity 0.0858581024725429 bayes_pls_golite062009
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle